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| Status |
Public on Mar 20, 2024 |
| Title |
The impact of endurance exercise on human skeletal muscle transcriptome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The aim of this study was to elucidate the transcriptional signatures that distinguish the endurance-trained and the untrained muscle in healthy adult young males, both at baseline as well as in response to an acute bout of exercise.
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| Overall design |
We characterized baseline differences as well as acute exercise-induced transcriptome responses in vastus lateralis biopsy specimen of endurance-trained athletes (ET; n = 8; age, 25.4 ±3.8; VO2max, 67.2 ±8.9 ml/min/kg) and sedentary untrained volunteers (SED; n = 8; age, 22.6 ±2.8; VO2max, 40.3 ±7.6 ml/min/kg) using Human Genome U219 (HG-U219) microarray platform. The acute exercise protocol that consisted of 60 min of high intensity cycling exercise on a cycle ergometer at a power requiring 80% of the individual VO2max (including 10 min of initial warm-up cycling at 60% VO2max). Baseline samples of the resting muscle were obtained 24 hours before the acute exercise protocol was started. Post exercise biopsies were taken at 30 min (+30') and at 3 hours (+3 h) after cessation of acute cycling exercise.
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| Contributor(s) |
Beiter T, Zügel M, Nieß AM, Mooren FC, Steinacker J |
| Citation(s) |
- Beiter T, Zügel M, Hudemann J, Schild M et al. The Acute, Short-, and Long-Term Effects of Endurance Exercise on Skeletal Muscle Transcriptome Profiles. Int J Mol Sci 2024 Mar 1;25(5). PMID: 38474128
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| Submission date |
Dec 13, 2023 |
| Last update date |
Mar 21, 2024 |
| Contact name |
Thomas Beiter |
| E-mail(s) |
thomas.beiter@med.uni-tuebingen.de
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| Phone |
4970712985233
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| Organization name |
Eberhard-Karls-University Tübingen
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| Department |
Sports Medicine
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| Street address |
Hoppe-Seyler-Str. 6
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| City |
Tübingen |
| ZIP/Postal code |
72076 |
| Country |
Germany |
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