<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE294138"><a href="/geo/query/acc.cgi?acc=GSE294138" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE294138</a></strong></td>

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<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE294138[Accession]">Query DataSets for GSE294138</a></td>

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<tr valign="top"><td>Status</td>

<td>Public on Apr 09, 2025</td>

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<tr valign="top"><td nowrap="">Title</td>

<td style="text-align: justify">Ribociclib derivative Rib-CA suppresses breast cancer progression by inducing p53-dependent apoptosis</td>

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<tr valign="top"><td nowrap="">Organism</td>

<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;id=9606" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Homo sapiens</a></td>

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<tr valign="top"><td nowrap="">Experiment type</td>

<td>Expression profiling by high throughput sequencing<br></td>

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<tr valign="top"><td nowrap="">Summary</td>

<td style="text-align: justify">RNA sequencing and bioinformatics analysis revealed 2628 differentially expressed genes, with functional enrichment indicating strong associations with the p53 pathway, apoptosis, and G2/M checkpoint regulation<br></td>

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<tr valign="top"><td nowrap="">&nbsp;</td>

<td></td>

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<tr valign="top"><td nowrap="">Overall design</td>

<td style="text-align: justify">In order to investigate the role and mechanism of Rib_CA in Breast Cancer, we treated MDA-MB-231 cells with Rib_CA and without treatment. Then, we performed gene expression profiling analysis using RNA seq data from Rib_CA and DMSO cells.<br></td>

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<tr valign="top"><td nowrap="">&nbsp;</td>

<td></td>

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<tr valign="top"><td>Contributor(s)</td>

<td><a href="/pubmed/?term=Song M[Author]">Song M</a>, <a href="/pubmed/?term=Ji J[Author]">Ji J</a></td>

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<tr valign="top"><td>Citation missing</td>

<td class="message" id="pmidCell">Has this study been published? Please <a href="/geo/submitter">login</a> to update or <a href="mailto:geo@ncbi.nlm.nih.gov?subject=Citation for GSE294138 [not logged in]&amp;body=Thank you very much for helping to keep GEO citation links up-to-date. Please enter the PubMed ID (PMID) or full citation for GSE294138 below, and we will update the record accordingly within the next day or two. The PubMed ID or citation is:

">notify GEO</a>.</td>

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<tr valign="top"><td colspan="2"><span id="geo2r"></span> <span id="rnaseq_counts"></span></td></tr>

<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td>

<td>Apr 09, 2025</td>

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<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td>

<td>Apr 09, 2025</td>

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<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td>

<td>Song meng wei</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">E-mail(s)</td>

<td><a href="mailto:swei97918@gmail.com">swei97918@gmail.com</a><br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td>

<td style="text-align: justify">Jiangsu Ocean University<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td>

<td style="text-align: justify">China<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td>

<td style="text-align: justify">Lianyungang</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td>

<td style="text-align: justify">222005</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td>

<td style="text-align: justify">China</td>

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<tr valign="top"><td nowrap="">&nbsp;</td>

<td></td>

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<tr valign="top"><td>Platforms (1)</td>

<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL11154" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL11154</a></td>

<td valign="top">Illumina HiSeq 2000 (Homo sapiens)</td>

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