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| Status |
Public on Apr 09, 2025 |
| Title |
Ribociclib derivative Rib-CA suppresses breast cancer progression by inducing p53-dependent apoptosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
RNA sequencing and bioinformatics analysis revealed 2628 differentially expressed genes, with functional enrichment indicating strong associations with the p53 pathway, apoptosis, and G2/M checkpoint regulation
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| Overall design |
In order to investigate the role and mechanism of Rib_CA in Breast Cancer, we treated MDA-MB-231 cells with Rib_CA and without treatment. Then, we performed gene expression profiling analysis using RNA seq data from Rib_CA and DMSO cells.
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| Contributor(s) |
Song M, Ji J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 09, 2025 |
| Last update date |
Apr 09, 2025 |
| Contact name |
Song meng wei |
| E-mail(s) |
swei97918@gmail.com
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| Organization name |
Jiangsu Ocean University
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| Street address |
China
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| City |
Lianyungang |
| ZIP/Postal code |
222005 |
| Country |
China |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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