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| Status |
Public on Apr 02, 2025 |
| Title |
Ferroptosis Induced by Omega-3 Docosahexaenoic Acid (DHA) and Erastin in Control MDA-MB-231 Cells (sh-LUC) and MDA-MB-231 Cells with knockdown of IGFBP6 gene (sh-IGFBP6) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we further elucidate the mechanism of action of one of the most effective antitumor PUFAs, ω-3 docosahexaenoic acid, on MDA-MB-231 breast cancer cells, including those with IGFBP6 knockdown. Additionally, we analyzed the effect of reduced IGFBP6 gene expression on the mechanism of ferroptosis in MDA-MB-231 breast cancer cells under the influence of the canonical ferroptosis inducer erastin.
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| Overall design |
Total RNA profiles of control MDA-MB-231 cells (sh-LUC) and MDA-MB-231cells with knockdown of IGFBP6 gene (sh-IGFBP6) treated with erastin and omega-3 docosahexaenoic Acid (DHA).
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| Contributor(s) |
Nikulin S, Razumovskaya A |
| Citation missing |
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| Submission date |
Nov 26, 2024 |
| Last update date |
Apr 02, 2025 |
| Contact name |
Sergey Nikulin |
| Organization name |
HSE University
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| Department |
Faculty of Biology and Biotechnology
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| Lab |
International Laboratory of Microphysiological Systems
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| Street address |
7, Vavilova st.
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| City |
Moscow |
| ZIP/Postal code |
117312 |
| Country |
Russia |
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| Platforms (1) |
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