STK11 serine/threonine kinase 11[Homo sapiens]
Gene ID: 6794, updated on 20-Apr-2023
SUMMARY
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Official Symbol: STK11 (provided by HGNC)
Official full name: serine/threonine kinase 11 (provided by HGNC)
Primary source: HGNC:HGNC:11389
See related: Ensembl:ENSG00000118046; MIM:602216; AllianceGenome:HGNC:11389
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PJS; LKB1; hLKB1
Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cell
polarity and energy metabolism and functions as a tumor suppressor. Mutations in
this gene have been associated with the autosomal dominant Peutz-Jeghers
syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by
RefSeq, May 2022]
Orthologsall (/gene/?Term=ortholog_gene_6794[group]), mouse (https://www.ncbi.nlm.nih.gov/gene/20869)
GENOMIC CONTEXT
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Location: 19p13.3
Annotation release Status Assembly Chromosome Location
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RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1205778..1228431)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1174325..1196989)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1205777..1228430)
Exont count: 12
BIBLIOGRAPHY
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Related Articles in PubMed
1. The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting
critical factors that mediate epithelial-mesenchymal transition. Tzavlaki K, . J
Cell Physiol, 2023 Apr, PMID 36791282.
2. LKB1 Loss Assessed by Immunohistochemistry as a Prognostic Marker to First-Line
Therapy in Advanced Non-Small-Cell Lung Cancer. Avilés-Salas A, . Curr Oncol,
2022 Dec 26, PMID 36661676., Free PMC Article(s): PMC9857995
3. STK11 Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage
Non-Small-Cell Lung Cancer. Katipally RR, . JCO Precis Oncol, 2023 Jan, PMID
36603171.
4. A novel missense mutation of the STK11 gene in a Chinese family with
Peutz-Jeghers syndrome. Yu Z, . BMC Gastroenterol, 2022 Dec 22, PMID 36550395., Free PMC Article(s): PMC9784088
5. Liver kinase B1 in exosomes inhibits immune checkpoint programmed death ligand 1
and metastatic progression of intrahepatic cholangiocarcinoma. Liu Z, . Oncol
Rep, 2022 Sep, PMID 35856436., Free PMC Article(s): PMC9350976
6. LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory
response. MacMillan S, . Commun Biol, 2022 Jun 29, PMID 35768580., Free PMC Article(s): PMC9243028
<pre>
PHENOTYPES
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Review eQTL and phenotype association data in this region using PheGenI
http://www.ncbi.nlm.nih.gov/gap/PheGenI?chr=19&from=1205777&fromto=1205777+1228430&tab=0
Professional guidelines
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Professional guideline
ACMG 2013
The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in STK11 that are pathogenic or expected to be pathogenic.
Guideline(http://www.acmg.net/docs/ACMG_Releases_Highly-Anticipated_Recommendations_on_Incidental_Findings_in_Clinical_Exome_and_Genome_Sequencing.pdf)
PubMed(/pubmed/23788249)
Associated conditions
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Description Tests
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Carcinoma of pancreas
MedGen: C0235974 OMIM: 260350 GeneReviews: <span>Not available</span>
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: <span>Not available</span>
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
GeneReviews: <span>Not available</span>
Germ cell tumor of testis
MedGen: C1336708 OMIM: 273300 GeneReviews: <span>Not available</span>
Melanoma, cutaneous malignant, susceptibility to, 1
MedGen: C1835047 OMIM: 155600 GeneReviews: <span>Not available</span>
Peutz-Jeghers syndrome
MedGen: C0031269 OMIM: 175200 GeneReviews: Peutz-Jeghers Syndrome
Copy number response
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Copy number response
Triplosensitivity
No evidence available (Last evaluated 2021-11-10)
ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=STK11)Haploinsufficency
Sufficient evidence for dosage pathogenicity (Last evaluated 2021-11-10)
ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=STK11)
PubMed(/pubmed/20623358,23892522,2563227,28231849)</pre>
VARIATION
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See variants in ClinVar, http://130.14.22.58/sites/gene/clinvar/?term=STK11[gene]
See studies and variants in dbVar, http://130.14.22.58/sites/gene
See Variation Viewer (GRCh37.p13), http://130.14.22.58/sites/gene/variation/view/?q=6794[geneid]&assm=GCF_000001405.25
See Variation Viewer (GRCh38), http://130.14.22.58/sites/gene/variation/view/?q=6794[geneid]<pre/><pre>
Genotypes
See SNP Geneview Report, http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2FSNP%2Fsnp_ref.cgi%3FlocusId%3D6794
See 1000 Genomes Browser (GCF_000001405.25), http://130.14.22.58/sites/gene/variation/tools/1000genomes/?q=6794[geneid]&assm=GCF_000001405.25</pre>
INTERACTION
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Description of Gene Interaction table
Product Interactant Other Gene Complex Source Pubs
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LKB1 phosphorylates MARK4.
NP_000446.1 NP_113605.2 MARK4 BIND PMID: 14676191
LKB1 interacts with AMPK-alpha.
NP_000446.1 NP_006243.2 PRKAA2 BIND PMID: 14985505
LKB1 autophosphorylates itself.
NP_000446.1 NP_000446.1 STK11 BIND PMID: 14676191
LKB1 phosphorylates PAPK.
NP_000446.1 NP_061041.2 STRADB BIND PMID: 14676191
Q15831 Q13315 ATM HPRD PMID: 12234250,11853558
Q15831 Q9Y376 CAB39 HPRD PMID: 14676191
Q15831 Q16543 CDC37 HPRD PMID: 12489981
Q15831 Q9P0L2 MARK1 HPRD PMID: 14976552,14517247
Q15831 Q7KZI7 MARK2 HPRD PMID: 14976552
Q15831 Q96L34 MARK4 HPRD PMID: 14676191
Q15831 Q9Y3A3 MOB4 HPRD PMID: 16169070
Q15831 Q8TEW0 PARD3 HPRD PMID: 14676191
Q15831 P54646 PRKAA2 HPRD PMID: 10642499
Q15831 P17612 PRKACA HPRD PMID: 11853558,11297520
Q15831 P60484 PTEN HPRD PMID: 15987703
Q15831 P51812 RPS6KA3 HPRD PMID: 11853558,11297520
Q15831 O75582 RPS6KA5 HPRD PMID: 11297520
Q15831 P23443 RPS6KB1 HPRD PMID: 11853558,11297520
Q15831 P51532 SMARCA4 HPRD PMID: 11445556
Q15831 Q9NRH2 SNRK HPRD PMID: 15733851
Q15831 Q15831 STK11 HPRD PMID: 11668633
Q15831 LKB1 interacting protein 1 STK11IP HPRD PMID: 11741830
Q15831 Protein kinase LYK5 STRADA HPRD PMID: 12805220
Q15831 Q9C0K7 STRADB HPRD PMID: 14676191
Q15831 TNFAIP3 interacting protein 2 TNIP2 HPRD PMID: 12595760
Q15831 P04637 TP53 HPRD PMID: 11430832
Affinity Capture-MS
BioGRID:112670 BioGRID:126860 A2ML1 BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:131028 ABCB5 BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:116784 ABRAXAS2 BioGRID PMID: 33961781,28514442
Two-hybrid
BioGRID:112670 BioGRID:119283 ADIPOR1 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:120419 AGGF1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:124393 AJUBA BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:115445 AKAP9 BioGRID PMID: 33961781
FRET; Two-hybrid
BioGRID:112670 BioGRID:106710 AKT1 BioGRID PMID: 28205554,24412244
Affinity Capture-MS
BioGRID:112670 BioGRID:111790 ALDH18A1 BioGRID PMID: 34591612
Two-hybrid
BioGRID:112670 BioGRID:106730 ALDOB BioGRID PMID: 24412244
Affinity Capture-MS
BioGRID:112670 BioGRID:106775 AMY1C BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:115795 ANP32B BioGRID PMID: 24412244
Affinity Capture-MS
BioGRID:112670 BioGRID:106798 ANXA1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:575558 ANXA8 BioGRID PMID: 33961781
Affinity Capture-Western
BioGRID:112670 BioGRID:107587 AP2M1 BioGRID PMID: 20368287
Reconstituted Complex
BioGRID:112670 BioGRID:106848 APP BioGRID PMID: 21832049
FRET
BioGRID:112670 BioGRID:106864 ARAF BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:106879 ARG2 BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:128219 ARID2 BioGRID PMID: 35559673
FRET
BioGRID:112670 BioGRID:106898 ARNT BioGRID PMID: 28205554
Negative Genetic
BioGRID:112670 BioGRID:121948 ATG101 BioGRID PMID: 35559673
Phenotypic Suppression
BioGRID:112670 BioGRID:115787 ATG7 BioGRID PMID: 33226137
Negative Genetic
BioGRID:112670 BioGRID:122518 ATG9A BioGRID PMID: 35559673
Affinity Capture-Western
BioGRID:112670 BioGRID:106962 ATM BioGRID PMID: 15713674
FRET
BioGRID:112670 BioGRID:112666 AURKA BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:198131 Ap2m1 BioGRID PMID: 20368287
Affinity Capture-MS
BioGRID:112670 BioGRID:118855 BABAM1 BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:113647 BAG6 BioGRID PMID: 35559673
Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:112670 BioGRID:113911 BAP1 BioGRID PMID: 32819560
Two-hybrid
BioGRID:112670 BioGRID:120182 BCAS3 BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:115118 BCLAF1 BioGRID PMID: 35559673
FRET
BioGRID:112670 BioGRID:114226 BECN1 BioGRID PMID: 28205554
Negative Genetic
BioGRID:112670 BioGRID:121521 BIRC6 BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:126647 BPIFA2 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:123248 BPIFB2 BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:107141 BRAF BioGRID PMID: 28205554
Negative Genetic
BioGRID:112670 BioGRID:122599 BRCC3 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:122430 BRD9 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:123841 BRIP1 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:107160 BTK BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:126409 C5orf24 BioGRID PMID: 33961781,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:131603 C6orf58 BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:124367 C8orf76 BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:107220 CA6 BioGRID PMID: 33961781
Affinity Capture-MS; Affinity Capture-Western; Co-localization
BioGRID:112670 BioGRID:119696 CAB39 BioGRID PMID: 35271311,34591612,33961781,32707033,31554794,31217475,28514442,25852190,25241761,20562859,15561763,14676191
Affinity Capture-MS
BioGRID:112670 BioGRID:123552 CAB39L BioGRID PMID: 33961781,28514442,26186194,20562859
Two-hybrid
BioGRID:112670 BioGRID:107256 CALM2 BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:127632 CAMSAP1 BioGRID PMID: 35559673
FRET
BioGRID:112670 BioGRID:117156 CBLC BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:122267 CCDC136 BioGRID PMID: 25852190
Two-hybrid
BioGRID:112670 BioGRID:1527673 CCDC180 BioGRID PMID: 24412244
FRET
BioGRID:112670 BioGRID:107334 CCND2 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:107338 CCNE1 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:107398 CD44 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:114125 CDC14B BioGRID PMID: 24412244
Affinity Capture-MS; Affinity Capture-Western
BioGRID:112670 BioGRID:116312 CDC37 BioGRID PMID: 34591612,33961781,32707033,21860411,20562859,14676191,14668798
FRET
BioGRID:112670 BioGRID:107454 CDK4 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:107456 CDK6 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:107463 CDKN2A BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:107464 CDKN2B BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:107465 CDKN2C BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:107500 CFL2 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:114729 COPS2 BioGRID PMID: 34591612,32707033
Affinity Capture-MS
BioGRID:112670 BioGRID:114103 COPS3 BioGRID PMID: 34591612,33961781,32707033,25852190
Affinity Capture-MS
BioGRID:112670 BioGRID:119324 COPS4 BioGRID PMID: 34591612,32707033,25852190
Affinity Capture-MS; Affinity Capture-Western
BioGRID:112670 BioGRID:116183 COPS5 BioGRID PMID: 34591612,30710502
Affinity Capture-MS
BioGRID:112670 BioGRID:116176 COPS6 BioGRID PMID: 34591612,32707033
Affinity Capture-MS
BioGRID:112670 BioGRID:119130 COPS7A BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:122237 COPS7B BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:116124 COPS8 BioGRID PMID: 34591612,32707033
Affinity Capture-MS
BioGRID:112670 BioGRID:119069 CRNN BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:107798 CRY2 BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:107836 CSNK1A1 BioGRID PMID: 35559673
Synthetic Lethality
BioGRID:112670 BioGRID:107841 CSNK2A1 BioGRID PMID: 27453043
Affinity Capture-MS
BioGRID:112670 BioGRID:107851 CST1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:107852 CST2 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:107854 CST4 BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:107888 CTSB BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:114031 CUL2 BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:114028 CUL4B BioGRID PMID: 32707033
Affinity Capture-MS
BioGRID:112670 BioGRID:115159 CUL7 BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:107919 CYLC2 BioGRID PMID: 24412244
Two-hybrid
BioGRID:112670 BioGRID:107958 CYP17A1 BioGRID PMID: 25640309
Two-hybrid
BioGRID:112670 BioGRID:608722 D2HGDH BioGRID PMID: 25640309
FRET
BioGRID:112670 BioGRID:107972 DACH1 BioGRID PMID: 28205554
Negative Genetic
BioGRID:112670 BioGRID:121945 DHX35 BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:108095 DMBT1 BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:108112 DNASE1 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:125472 DNTTIP1 BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:108164 DSG3 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:108189 DVL2 BioGRID PMID: 28514442
Two-hybrid
BioGRID:112670 BioGRID:108238 EEF1A2 BioGRID PMID: 25640309
Affinity Capture-Western
BioGRID:112670 BioGRID:108286 EIF2B1 BioGRID PMID: 20368287
Affinity Capture-MS
BioGRID:112670 BioGRID:114423 ENDOU BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:108288 EPHA2 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:108376 ERBB2 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:118096 ERLEC1 BioGRID PMID: 25640309
Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:112670 BioGRID:108419 ETV4 BioGRID PMID: 21150337,16912160
Affinity Capture-MS
BioGRID:112670 BioGRID:108426 EVPL BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:229070 Eif2b1 BioGRID PMID: 20368287
Two-hybrid
BioGRID:112670 BioGRID:116659 FAIM2 BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:123086 FAM106A BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:108472 FANCA BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:108483 FANCF BioGRID PMID: 35559673
Two-hybrid
BioGRID:112670 BioGRID:108497 FBP1 BioGRID PMID: 24412244
Two-hybrid
BioGRID:112670 BioGRID:114317 FBP2 BioGRID PMID: 24412244
Affinity Capture-Western
BioGRID:112670 BioGRID:126870 FBXL14 BioGRID PMID: 29601127
Affinity Capture-Western; Co-localization
BioGRID:112670 BioGRID:117649 FBXO22 BioGRID PMID: 31217475
Negative Genetic
BioGRID:112670 BioGRID:127320 FBXO41 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:119962 FBXO42 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:116887 FBXW11 BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:117645 FBXW8 BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:108555 FGFR4 BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:108578 FKBP4 BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:108579 FKBP5 BioGRID PMID: 34591612,33961781,32707033,28514442,25852190,20562859,14676191
Affinity Capture-MS
BioGRID:112670 BioGRID:108601 FLG BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:122669 FYCO1 BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:119489 FZR1 BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:108887 GARS1 BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:127864 GBP6 BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:124182 GLIS2 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:115325 GNPDA1 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:109131 GPS1 BioGRID PMID: 34591612,32707033
FRET
BioGRID:112670 BioGRID:109168 GRM1 BioGRID PMID: 28205554
Affinity Capture-Western
BioGRID:112670 BioGRID:109187 GSK3B BioGRID PMID: 22270359
Negative Genetic
BioGRID:112670 BioGRID:114937 GTPBP1 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:120097 GTPBP2 BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:109268 H2AX BioGRID PMID: 25852190
Affinity Capture-MS
BioGRID:112670 BioGRID:109284 HAL BioGRID PMID: 33961781
Affinity Capture-Western; Biochemical Activity
BioGRID:112670 BioGRID:114438 HERC2 BioGRID PMID: 27259994
FRET
BioGRID:112670 BioGRID:109330 HGF BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:109338 HIF1A BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:109345 HK1 BioGRID PMID: 34591612
Negative Genetic
BioGRID:112670 BioGRID:109465 HOXC9 BioGRID PMID: 35559673
Two-hybrid
BioGRID:112670 BioGRID:109501 HRAS BioGRID PMID: 24412244
Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western
BioGRID:112670 BioGRID:109552 HSP90AA1 BioGRID PMID: 33961781,32707033,28514442,22939624,21860411,14676191,14668798
Affinity Capture-MS
BioGRID:112670 BioGRID:109555 HSP90AA4P BioGRID PMID: 33961781,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:610599 HSP90AA5P BioGRID PMID: 33961781,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:109558 HSP90AB1 BioGRID PMID: 33961781,32707033,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:109559 HSP90AB3P BioGRID PMID: 33961781,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:576430 HSP90AB4P BioGRID PMID: 33961781,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:109535 HSPA1A BioGRID PMID: 14676191
Affinity Capture-MS
BioGRID:112670 BioGRID:118149 HTATSF1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:120824 IARS2 BioGRID PMID: 34591612
Two-hybrid
BioGRID:112670 BioGRID:109707 IGFBP3 BioGRID PMID: 24412244
Affinity Capture-MS
BioGRID:112670 BioGRID:109714 IGHA1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:109715 IGHA2 BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:114089 IKBKG BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:109772 IL1RN BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:129701 INO80E BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:109916 IVD BioGRID PMID: 34591612,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:109917 IVL BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:109732 JCHAIN BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:116105 JTB BioGRID PMID: 35559673
FRET
BioGRID:112670 BioGRID:108918 KAT2A BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:116204 KDELR2 BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:115035 KDM4A BioGRID PMID: 33961781,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:114873 KIF23 BioGRID PMID: 14676191
Affinity Capture-MS
BioGRID:112670 BioGRID:111636 KLK10 BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:111631 KLK7 BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:110038 KPNA4 BioGRID PMID: 35559673
Affinity Capture-Western
BioGRID:112670 BioGRID:120336 LAMTOR1 BioGRID PMID: 34821530
FRET
BioGRID:112670 BioGRID:117727 LATS2 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:119354 LEF1 BioGRID PMID: 24412244
Affinity Capture-MS
BioGRID:112670 BioGRID:110175 LIMS1 BioGRID PMID: 14676191
Affinity Capture-MS
BioGRID:112670 BioGRID:110201 LOXL2 BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:110208 LPP BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:110235 LTF BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:117985 LYPD3 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:110247 LYZ BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:116348 LZTS1 BioGRID PMID: 35559673
Synthetic Lethality; Two-hybrid
BioGRID:112670 BioGRID:111590 MAP2K1 BioGRID PMID: 27453043,24412244
Affinity Capture-Western; FRET
BioGRID:112670 BioGRID:111592 MAP2K3 BioGRID PMID: 28628118,28205554
FRET
BioGRID:112670 BioGRID:111593 MAP2K5 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:111594 MAP2K6 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:110381 MAP3K5 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:107819 MAPK14 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:111581 MAPK3 BioGRID PMID: 24412244
Two-hybrid
BioGRID:112670 BioGRID:116581 MAPRE1 BioGRID PMID: 24552808
Biochemical Activity
BioGRID:112670 BioGRID:108326 MARK2 BioGRID PMID: 16396636
Affinity Capture-Western
BioGRID:112670 BioGRID:121760 MARK4 BioGRID PMID: 14676191
Negative Genetic
BioGRID:112670 BioGRID:129033 MCM9 BioGRID PMID: 35559673
Affinity Capture-Western; FRET
BioGRID:112670 BioGRID:110358 MDM2 BioGRID PMID: 35513074,28205554
FRET
BioGRID:112670 BioGRID:110391 MET BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:119275 MLXIPL BioGRID PMID: 34461288
Affinity Capture-MS; Co-localization
BioGRID:112670 BioGRID:122103 MMS19 BioGRID PMID: 34591612
Two-hybrid
BioGRID:112670 BioGRID:110481 MOCS2 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:110493 MPO BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:110498 MPV17 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:125820 MTFMT BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:114560 MTMR4 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:608337 MUC5B BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:110676 MUC7 BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:110694 MYC BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:119921 NANS BioGRID PMID: 24412244
Two-hybrid
BioGRID:112670 BioGRID:106528 NAT2 BioGRID PMID: 25640309
Two-hybrid
BioGRID:112670 BioGRID:110632 ND2 BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:110792 NDUFB6 BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:114594 NEMF BioGRID PMID: 28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:115983 NES BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:110844 NF2 BioGRID PMID: 28205554
Negative Genetic
BioGRID:112670 BioGRID:117008 OTP BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:116413 PACSIN2 BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:111182 PDGFRA BioGRID PMID: 28205554
Negative Genetic
BioGRID:112670 BioGRID:116848 PDS5A BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:117125 PDSS1 BioGRID PMID: 35559673
Two-hybrid
BioGRID:112670 BioGRID:121330 PDXP BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:111788 PEX5 BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:122561 PHF23 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:111302 PIGR BioGRID PMID: 33961781
FRET
BioGRID:112670 BioGRID:111308 PIK3CA BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:111322 PIP4K2A BioGRID PMID: 33961781,32707033,28514442
Affinity Capture-MS
BioGRID:112670 BioGRID:113985 PIP4K2B BioGRID PMID: 32707033
Affinity Capture-MS
BioGRID:112670 BioGRID:122928 PIP4K2C BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:114074 PKP4 BioGRID PMID: 34591612
Two-hybrid
BioGRID:112670 BioGRID:117173 PLD3 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:126828 PLEKHA7 BioGRID PMID: 34591612
Affinity Capture-MS
BioGRID:112670 BioGRID:123048 POF1B BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:111488 PPL BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:111508 PPP2CB BioGRID PMID: 24412244
Negative Genetic
BioGRID:112670 BioGRID:120344 PPP2R3C BioGRID PMID: 35559673
Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:112670 BioGRID:111549 PRKAA1 BioGRID PMID: 31995728,31217475,16912160
Co-localization
BioGRID:112670 BioGRID:111550 PRKAA2 BioGRID PMID: 25241761
Co-localization
BioGRID:112670 BioGRID:111558 PRKAG1 BioGRID PMID: 31983282
Negative Genetic
BioGRID:112670 BioGRID:114143 PRKRA BioGRID PMID: 35559673
Two-hybrid
BioGRID:112670 BioGRID:118887 PRSS50 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:111638 PRTN3 BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:114872 PSMF1 BioGRID PMID: 35559673
Affinity Capture-Western; Biochemical Activity; Co-localization; Two-hybrid
BioGRID:112670 BioGRID:111700 PTEN BioGRID PMID: 15987703
Two-hybrid
BioGRID:112670 BioGRID:111856 RASA1 BioGRID PMID: 24412244
FRET
BioGRID:112670 BioGRID:116356 RASSF1 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:116828 RHOBTB2 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:121946 RIC8A BioGRID PMID: 34591612
Affinity Capture-RNA
BioGRID:112670 BioGRID:117121 RIGI BioGRID PMID: 32513696
Affinity Capture-MS
BioGRID:112670 BioGRID:120896 RIOK2 BioGRID PMID: 33961781
Affinity Capture-Western
BioGRID:112670 BioGRID:123598 RNF146 BioGRID PMID: 31554794
Affinity Capture-MS
BioGRID:112670 BioGRID:122783 RPAP3 BioGRID PMID: 14676191
Negative Genetic
BioGRID:112670 BioGRID:121820 RPRD1B BioGRID PMID: 35559673
Co-localization
BioGRID:112670 BioGRID:112112 RPS6KB1 BioGRID PMID: 25241761
Two-hybrid
BioGRID:112670 BioGRID:121504 S100A14 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:112188 S100A9 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:114324 SCEL BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:112291 SDHB BioGRID PMID: 35559673
Two-hybrid
BioGRID:112670 BioGRID:116015 SEPTIN9 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:108307 SERPINB1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:111293 SERPINB13 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:112223 SERPINB3 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:112224 SERPINB4 BioGRID PMID: 33961781
Affinity Capture-MS; Two-hybrid
BioGRID:112670 BioGRID:111286 SERPINB5 BioGRID PMID: 33961781,25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:118845 SETD2 BioGRID PMID: 33961781
Biochemical Activity
BioGRID:112670 BioGRID:127260 SIK1 BioGRID PMID: 16396636
Affinity Capture-Western; Biochemical Activity
BioGRID:112670 BioGRID:116983 SIRT1 BioGRID PMID: 27259994,18687677
Negative Genetic
BioGRID:112670 BioGRID:124002 SLC25A33 BioGRID PMID: 35559673
Negative Genetic
BioGRID:112670 BioGRID:115726 SLC30A9 BioGRID PMID: 35559673
FRET
BioGRID:112670 BioGRID:110261 SMAD1 BioGRID PMID: 28205554
Affinity Capture-MS; Affinity Capture-Western; FRET; Reconstituted Complex
BioGRID:112670 BioGRID:112481 SMARCA4 BioGRID PMID: 28205554,14676191,11445556
Affinity Capture-MS
BioGRID:112670 BioGRID:112483 SMARCC1 BioGRID PMID: 14676191
Affinity Capture-Western
BioGRID:112670 BioGRID:112499 SNAI1 BioGRID PMID: 29601127
Biochemical Activity
BioGRID:112670 BioGRID:120211 SNRK BioGRID PMID: 15733851
Affinity Capture-MS
BioGRID:112670 BioGRID:119535 SNX9 BioGRID PMID: 33961781
Negative Genetic
BioGRID:112670 BioGRID:119936 SOX18 BioGRID PMID: 35559673
FRET
BioGRID:112670 BioGRID:112542 SOX4 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:117335 SPDEF BioGRID PMID: 16912160
Affinity Capture-MS
BioGRID:112670 BioGRID:112585 SPRR3 BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:112645 ST14 BioGRID PMID: 25640309
FRET
BioGRID:112670 BioGRID:112670 STK11 BioGRID PMID: 28205554
Affinity Capture-Western
BioGRID:112670 BioGRID:125352 STK11IP BioGRID PMID: 11741830
Two-hybrid
BioGRID:112670 BioGRID:114011 STK24 BioGRID PMID: 25640309
Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:112670 BioGRID:124934 STRADA BioGRID PMID: 35271311,34591612,33961781,32707033,31554794,28514442,25852190,25241761,21860411,20562859,15561763,14676191,12805220
Affinity Capture-MS; Biochemical Activity
BioGRID:112670 BioGRID:120668 STRADB BioGRID PMID: 35271311,34591612,33961781,32707033,28514442,20562859,14676191
Affinity Capture-Western
BioGRID:112670 BioGRID:115563 STUB1 BioGRID PMID: 21860411
Two-hybrid
BioGRID:112670 BioGRID:120346 STX17 BioGRID PMID: 24412244
Affinity Capture-MS
BioGRID:112670 BioGRID:112689 SULT2B1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:112697 SUPT5H BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:112698 SUPT6H BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:120889 TBC1D23 BioGRID PMID: 21516116
Two-hybrid
BioGRID:112670 BioGRID:116994 TDRD7 BioGRID PMID: 24412244
FRET
BioGRID:112670 BioGRID:114041 TEAD2 BioGRID PMID: 28205554
FRET
BioGRID:112670 BioGRID:112874 TERT BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:112909 TGM1 BioGRID PMID: 33961781
Affinity Capture-MS
BioGRID:112670 BioGRID:112911 TGM3 BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:112921 THOP1 BioGRID PMID: 25640309
Two-hybrid
BioGRID:112670 BioGRID:112925 THRSP BioGRID PMID: 25640309
FRET
BioGRID:112670 BioGRID:112986 TNFRSF1A BioGRID PMID: 28205554
Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112670 BioGRID:122573 TNIP2 BioGRID PMID: 27609421,12753905,12595760
Affinity Capture-Western
BioGRID:112670 BioGRID:114207 TNKS BioGRID PMID: 31554794
Affinity Capture-Western
BioGRID:112670 BioGRID:123257 TNKS2 BioGRID PMID: 31554794
Affinity Capture-MS; Affinity Capture-Western; FRET
BioGRID:112670 BioGRID:113010 TP53 BioGRID PMID: 33961781,28205554,11430832
Affinity Capture-Western
BioGRID:112670 BioGRID:114181 TP63 BioGRID PMID: 21150337
Two-hybrid
BioGRID:112670 BioGRID:113500 TRIM25 BioGRID PMID: 25640309
Two-hybrid
BioGRID:112670 BioGRID:119593 TRMO BioGRID PMID: 24412244
Negative Genetic
BioGRID:112670 BioGRID:113100 TSC2 BioGRID PMID: 35559673
Two-hybrid
BioGRID:112670 BioGRID:113102 TSG101 BioGRID PMID: 25640309
Two-hybrid
BioGRID:112670 BioGRID:113603 TUBA1A BioGRID PMID: 25640309
Two-hybrid
BioGRID:112670 BioGRID:115655 TUBB4A BioGRID PMID: 25640309
Negative Genetic
BioGRID:112670 BioGRID:113149 TYMS BioGRID PMID: 35559673
Biochemical Activity
BioGRID:112670 BioGRID:113170 UBE2D2 BioGRID PMID: 21860411
Affinity Capture-Western
BioGRID:112670 BioGRID:121973 UBE2O BioGRID PMID: 31900314
Negative Genetic
BioGRID:112670 BioGRID:118858 UBE2T BioGRID PMID: 35559673
Affinity Capture-MS
BioGRID:112670 BioGRID:113866 USP11 BioGRID PMID: 14676191
Two-hybrid
BioGRID:112670 BioGRID:112804 VPS72 BioGRID PMID: 25640309
Affinity Capture-MS
BioGRID:112670 BioGRID:121649 WDR48 BioGRID PMID: 19615732
Affinity Capture-Western
BioGRID:112670 BioGRID:116350 WDR6 BioGRID PMID: 17216128
FRET
BioGRID:112670 BioGRID:113327 WT1 BioGRID PMID: 28205554
Two-hybrid
BioGRID:112670 BioGRID:113344 XPA BioGRID PMID: 24412244
Negative Genetic
BioGRID:112670 BioGRID:119655 YPEL5 BioGRID PMID: 35559673
FRET
BioGRID:112670 BioGRID:113364 YWHAG BioGRID PMID: 28205554
Affinity Capture-MS
BioGRID:112670 BioGRID:125855 ZG16B BioGRID PMID: 33961781
Two-hybrid
BioGRID:112670 BioGRID:113528 ZNF189 BioGRID PMID: 24412244
Two-hybrid
BioGRID:112670 BioGRID:116536 ZNF510 BioGRID PMID: 24412244
GENERAL GENE INFO
-------------------------------------------------------------------------------------------------
Marker
REU1905 (e-PCR) Links:UniSTS:257089
RH104368 (e-PCR) Links:UniSTS:98693
Stk11 (e-PCR), detects polymorphism Links:UniSTS:546518
Homology
Homologs of the STK11 gene
The STK11 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline (/gene/?Term=ortholog_gene_6794[group]):
Orthologs
Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
Function GO ID Evidence
-------------------------------------------------------------------------------------------------
enables ATP binding GO:0000000 PMID: 12805220
enables LRR domain binding GO:0000000 -
enables magnesium ion binding GO:0000000 PMID: 12805220
enables p53 binding GO:0000000 PMID: 11430832
enables protein binding GO:0000000 PMID: 12595760,12753905,12805220,14676191,17216128,19274086,19513107,19892943,20562859,22575644,22939624,24362629,25036637,25241761,25329316,25852190,26479318,28514442,32707033,34591612
enables protein kinase activator activit... GO:0000000 PMID: 19892943
enables protein serine kinase activity GO:0000000 -
enables protein serine/threonine kinase ... GO:0000000 PMID: 21873635
enables protein serine/threonine kinase ... GO:0000000 PMID: 11430832,12805220,19892943
enables protein serine/threonine kinase ... GO:0000000 -
enables protein-containing complex bindi... GO:0000000 -
Processs GO ID Evidence
-------------------------------------------------------------------------------------------------
involved_in DNA damage response GO:0000000 PMID: 21873635
involved_in DNA damage response GO:0000000 PMID: 25329316
acts_upstream_of_negative_effect G1 to G... GO:0000000 PMID: 17216128
acts_upstream_of_negative_effect G1 to G... GO:0000000 PMID: 12805220
involved_in Golgi localization GO:0000000 -
involved_in T cell receptor signaling pa... GO:0000000 -
involved_in activation of protein kinase... GO:0000000 PMID: 19892943
involved_in activation of protein kinase... GO:0000000 PMID: 15731909
involved_in activation of protein kinase... GO:0000000 -
involved_in anoikis GO:0000000 PMID: 19622832
involved_in autophagy GO:0000000 -
involved_in axonogenesis GO:0000000 -
involved_in cellular response to UV-B GO:0000000 PMID: 25329316
involved_in dendrite extension GO:0000000 -
involved_in epithelial cell proliferatio... GO:0000000 -
involved_in establishment of cell polari... GO:0000000 PMID: 21873635
involved_in establishment of cell polari... GO:0000000 PMID: 24643070
involved_in establishment of cell polari... GO:0000000 -
involved_in glucose homeostasis GO:0000000 -
involved_in intrinsic apoptotic signalin... GO:0000000 PMID: 11430832
involved_in negative regulation of TORC1... GO:0000000 PMID: 23878245
involved_in negative regulation of canon... GO:0000000 PMID: 15731909
involved_in negative regulation of cell ... GO:0000000 -
involved_in negative regulation of cell ... GO:0000000 PMID: 17216128,25329316
involved_in negative regulation of cold-... GO:0000000 PMID: 27461402
involved_in negative regulation of epith... GO:0000000 -
involved_in peptidyl-threonine phosphory... GO:0000000 PMID: 12805220
involved_in positive regulation of autop... GO:0000000 PMID: 23878245
involved_in positive regulation of axono... GO:0000000 -
involved_in positive regulation of gluco... GO:0000000 -
involved_in positive regulation of prote... GO:0000000 -
involved_in positive regulation of trans... GO:0000000 PMID: 18311138
involved_in positive regulation of vesic... GO:0000000 PMID: 21873635
involved_in positive regulation of vesic... GO:0000000 PMID: 24643070
involved_in positive thymic T cell selec... GO:0000000 -
involved_in protein autophosphorylation GO:0000000 PMID: 11430832
involved_in protein dephosphorylation GO:0000000 PMID: 15731909
involved_in protein localization to nucl... GO:0000000 -
involved_in protein phosphorylation GO:0000000 PMID: 21873635
involved_in protein phosphorylation GO:0000000 PMID: 12805220,25329316
involved_in regulation of Wnt signaling ... GO:0000000 PMID: 21873635
involved_in regulation of cell cycle GO:0000000 -
involved_in regulation of cell growth GO:0000000 -
involved_in regulation of dendrite morph... GO:0000000 -
involved_in regulation of protein kinase... GO:0000000 -
involved_in regulation of signal transdu... GO:0000000 -
involved_in response to activity GO:0000000 -
involved_in response to glucagon GO:0000000 -
involved_in response to ionizing radiati... GO:0000000 -
involved_in response to lipid GO:0000000 -
involved_in response to thyroid hormone GO:0000000 -
involved_in signal transduction GO:0000000 PMID: 21873635
involved_in spermatogenesis GO:0000000 -
involved_in tissue homeostasis GO:0000000 -
involved_in vasculature development GO:0000000 -
Component GO ID Evidence
-------------------------------------------------------------------------------------------------
located_in Z disc GO:0000000 -
is_active_in cytoplasm GO:0000000 PMID: 21873635
located_in cytoplasm GO:0000000 PMID: 11430832,12805220,14517248,17216128,18854309
located_in cytoplasm GO:0000000 -
located_in cytosol GO:0000000 -
located_in cytosol GO:0000000 -
located_in cytosol GO:0000000 -
located_in extracellular exosome GO:0000000 PMID: 19056867
part_of intracellular protein-containing... GO:0000000 PMID: 12805220
located_in membrane GO:0000000 -
located_in mitochondrion GO:0000000 PMID: 11430832
located_in nucleoplasm GO:0000000 -
located_in nucleoplasm GO:0000000 -
is_active_in nucleus GO:0000000 PMID: 21873635
located_in nucleus GO:0000000 PMID: 12805220,18854309
part_of serine/threonine protein kinase ... GO:0000000 PMID: 19892943
part_of serine/threonine protein kinase ... GO:0000000 -
GENERAL PROTEIN INFORMATION
-------------------------------------------------------------------------------------------------
Preferred Names
serine/threonine-protein kinase STK11
Names
liver kinase B1
polarization-related protein LKB1
renal carcinoma antigen NY-REN-19
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1
NP_000446.1
EC 2.7.11.1
NP_001394184.1
EC 2.7.11.1
NCBI REFERENCE SEQUENCES (RefSeq)
-------------------------------------------------------------------------------------------------
RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds.
These reference sequences are curated independently of the genome annotation cycle,
so their versions may not match the RefSeq versions in the current genome build.
Identify version mismatches by comparing the version of the RefSeq in this section to
the one reported in Genomic regions, transcripts, and products section above.
Genomic
NG_007460.2 RefSeqGene
Range 21392..44028
Download GenBank FASTA Sequence Viewer (Graphics)
mRNA and Protein(s)
NM_000455.5 → NP_000446.1 REVIEWEDserine/threonine-protein kinase STK11 isoform 1
See proteins identical to NP_000446.1 at http://130.14.22.58/ipg/NP_000446.1/
Source sequence(s): AC011544, BC007981, BC019334, BM993274, BQ222023, BU174122, BU739451
Consensus CDS: CCDS45896.1
UniProtKB/TrEMBL: A0A0S2Z4D1
UniProtKB/Swiss-Prot: E7EW76
UniProtKB/Swiss-Prot: Q15831
Related Ensembl: ENSP00000324856.6, ENST00000326873.12
Conserved Domains (1)summary
cd14119:
Location:55 - 309
STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_001407255.1 → NP_001394184.1 REVIEWEDserine/threonine-protein kinase STK11 isoform 2
Source sequence(s): AC011544
RNA
NR_176325.1 RNA Sequence
Source sequence(s): AC004221, AC011544
RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03
The following sections contain reference sequences that belong to a specific genome build.
This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which
this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both
reference and alternate assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
NC_000019.10 Reference GRCh38.p14 Primary Assembly
Range 1205777..1228430
Download GenBank FASTA Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
NC_060943.1 Alternate T2T-CHM13v2.0
Range 1174324..1196988
Download GenBank FASTA Sequence Viewer (Graphics)
RELATED SEQUENCES
-------------------------------------------------------------------------------------------------
Nucleotide Protein
-------------------------------------------------------------------------------------------------
genomic AC004221.2 AAF97257.1
genomic AC011544.6(26171..45903) None
genomic AH005839.2 AAB97833.1
genomic AH006100.2 AAC15742.1
genomic CH471139.2 EAW69538.1
EAW69539
EAW69540
genomic CP068259.2(1174325..1196989) None
mRNA AB209553.1 BAD92790.1
mRNA AF035625.1 AAC39527.1
mRNA AF217978.1 AAG17221.1
mRNA AJ844634.2 CAH59749.2
mRNA AK128518.1 None
mRNA AK314858.1 BAG37374.1
mRNA BC007981.2 AAH07981.1
mRNA BC019334.1 AAH19334.1
mRNA BM993274.1 None
mRNA BQ222023.1 None
mRNA BU174122.1 None
mRNA BU739451.1 None
mRNA EF644172.1 ABR45718.1
mRNA GU573916.1 ADD71158.1
mRNA KU178339.1 ALQ33797.1
mRNA KU178340.1 ALQ33798.1
mRNA U63333.1 AAB05809.1
Protein Accession Links
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Q15831.1 GenPept(/protein/3024670) UniProtKB/Swiss-Prot:Q15831
GENE LINKOUT
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The following LinkOut(www.ncbi.nlm.nih.gov/projects/linkout/index.html) resources
are supplied by external providers. These providers are responsible for
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Chemical Information
(Free resource) (free) Interologous Interaction Database
Interologous Interaction Database
(Order form) MilliporeSigma
Stk11 productsStk11 products
(Order form) Novus Biologicals
Peptides and ProteinsPeptides and ProteinsLysatesLysatesPrimary AntibodiesPrimary Antibodies
Medical
(Free resource) (free) MedlinePlus Health Information
STK11 geneSTK11 gene
Molecular Biology Databases
(Free resource) (free) Bgee database
STK11 gene expressionSTK11 gene expression
(Free resource) (free) BioGPS
BioGPS
(Free resource) (free) BioGRID Open Repository of CRISPR Screens (ORCS)
BioGRID CRISPR Screen Phenotypes (153 hits/1229 screens)BioGRID CRISPR Screen Phenotypes (153 hits/1229 screens)
(Free resource) (free) CREB Target Gene Database
CREB Target Gene Database
(Free resource) (Free registration required) (free) Creative Biogene
serine/threonine kinase 11serine/threonine kinase 11
(Free resource) (free) Eukaryotic Promoter Database
STK11_1STK11_1
(Free resource) (free) GenAge Database of Aging Related Genes
GenAge Database of Aging Related Genes
(Order form) GenScript latest version of gene cDNA ORF Clone
GenScript latest version of gene cDNA ORF Clone
(Free resource) (free) GeneNetwork
Records for gene expression in HumanRecords for gene expression in Human
(Free resource) (free) Genevisible
STK11STK11
(Free resource) (free) GlyGen glycoinformatics resource
GlyGen glycoinformatics resource
(Free resource) (free) Guide to Pharmacology
serine/threonine kinase 11 geneserine/threonine kinase 11 gene
(Free resource) (Free registration required) (free) Human Gene Mutation Database
Human Gene Mutation Database
(Free resource) (free) Human eFP Browser
Human eFP BrowserHuman eFP BrowserHuman eFP Browser
Ingenuity Pathways Analysis
Ingenuity Pathways Analysis
(Free resource) (free) InnateDB
InnateDB
(Free resource) (free) InterMine
InterMine
(Free resource) (free) Kyoto Encyclopedia of Genes and Genomes
Kyoto Encyclopedia of Genes and Genomes
(Free resource) (free) Monarch Initiative
Monarch InitiativeMonarch Initiative
(Free resource) (free) OMA Browser: Orthologous MAtrix
OMA Browser: Orthologous MAtrixOMA Browser: Orthologous MAtrix
(Free resource) (free) OrthoDB catalog of orthologs
OrthologsOrthologs
(Free resource) (free) Pharmacogenomics Knowledge Base
Annotated Pharmacogenomic Information for STK11 [PharmGKB]Annotated Pharmacogenomic Information for STK11 [PharmGKB]
(Free resource) (free) PhosphoSitePlus
PhosphoSitePlus® - comprehensive post-translational modification resourcePhosphoSitePlus® - comprehensive post-translational modification resource
(Free resource) (free) Protein Ontology Consortium
Protein Ontology Consortium
(Free resource) (free) The Gene Wiki
The Gene Wiki
(Free resource) (free) The Weizmann Institute of Science GeneCards and MalaCards databases
GeneCard for STK11GeneCard for STK11
(Free resource) (free) Vertebrate Genome Annotation (VEGA) database
Vertebrate Genome Annotation (VEGA) database
(Free resource) (free) iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
Research Materials
(Order form) Addgene Non-profit plasmid repository
Get Plasmids - AddgeneGet Plasmids - Addgene
ExactAntigen/Labome
reagent reviewreagent reviewreagentsreagents
(Order form) GeneCopoeia Inc.
Order miRNA target clonesOrder miRNA target clonesOrder shRNA clonesOrder shRNA clonesOrder full-length ORF cloneOrder full-length ORF clone
(Order form) GeneTex Inc
Find Recombinant Proteins and PeptidesFind Recombinant Proteins and PeptidesFind Quality AntibodiesFind Quality Antibodies
(Order form) Kazusa DNA Research Institute
Kazusa DNA Research Institute
LifeSpan BioSciences, Inc.
LSBio STK11 / LKB1 ProteinsLSBio STK11 / LKB1 Proteins
(Order form) NITE Biological Resource Center
Human cDNA clones used in NEDO Project / AK314858Human cDNA clones used in NEDO Project / AK314858Human cDNA clones used in NEDO Project / AK128518Human cDNA clones used in NEDO Project / AK128518
(Order form) Sino Biological Inc.
Human STK11 / LKB1 Gene cDNA Clone (full-length ORF Clone)Human STK11 / LKB1 Gene cDNA Clone (full-length ORF Clone)
Tools
(Free resource) (free) GeneMANIA
GeneMANIA
