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STK11 serine/threonine kinase 11[Homo sapiens]
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Gene ID: 6794, updated on 20-Apr-2023
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SUMMARY
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-------------------------------------------------------------------------------------------------
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Official Symbol: STK11 (provided by HGNC)
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Official full name: serine/threonine kinase 11 (provided by HGNC)
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Primary source: HGNC:HGNC:11389
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See related: Ensembl:ENSG00000118046; MIM:602216; AllianceGenome:HGNC:11389
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Gene type: protein coding
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RefSeq status: REVIEWED
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Organism: Homo sapiens
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Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
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Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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Also known as: PJS; LKB1; hLKB1
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Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cell
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polarity and energy metabolism and functions as a tumor suppressor. Mutations in 
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this gene have been associated with the autosomal dominant Peutz-Jeghers
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syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by 
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RefSeq, May 2022]
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Orthologsall (/gene/?Term=ortholog_gene_6794[group]), mouse (https://www.ncbi.nlm.nih.gov/gene/20869)
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GENOMIC CONTEXT
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-------------------------------------------------------------------------------------------------
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Location: 19p13.3
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Annotation release  Status  Assembly    Chromosome  Location
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-------------------------------------------------------------------------------------------------
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RS_2023_03  current GRCh38.p14 (GCF_000001405.40)   19  NC_000019.10 (1205778..1228431) 
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RS_2023_03  current T2T-CHM13v2.0 (GCF_009914755.1) 19  NC_060943.1 (1174325..1196989) 
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105.20220307    previous assembly   GRCh37.p13 (GCF_000001405.25)   19  NC_000019.9 (1205777..1228430) 
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Exont count: 12
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BIBLIOGRAPHY
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Related Articles in PubMed
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1. The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting
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critical factors that mediate epithelial-mesenchymal transition. Tzavlaki K, . J 
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Cell Physiol, 2023 Apr, PMID 36791282.
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2. LKB1 Loss Assessed by Immunohistochemistry as a Prognostic Marker to First-Line
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Therapy in Advanced Non-Small-Cell Lung Cancer. Avilés-Salas A, . Curr Oncol,
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2022 Dec 26, PMID 36661676., Free PMC Article(s): PMC9857995
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3. STK11 Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage
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Non-Small-Cell Lung Cancer. Katipally RR, . JCO Precis Oncol, 2023 Jan, PMID
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36603171.
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4. A novel missense mutation of the STK11 gene in a Chinese family with
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Peutz-Jeghers syndrome. Yu Z, . BMC Gastroenterol, 2022 Dec 22, PMID 36550395., Free PMC Article(s): PMC9784088
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5. Liver kinase B1 in exosomes inhibits immune checkpoint programmed death ligand 1 
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and metastatic progression of intrahepatic cholangiocarcinoma. Liu Z, . Oncol
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Rep, 2022 Sep, PMID 35856436., Free PMC Article(s): PMC9350976
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6. LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory
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response. MacMillan S, . Commun Biol, 2022 Jun 29, PMID 35768580., Free PMC Article(s): PMC9243028
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<pre>
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PHENOTYPES
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-------------------------------------------------------------------------------------------------
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Review eQTL and phenotype association data in this region using PheGenI
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    http://www.ncbi.nlm.nih.gov/gap/PheGenI?chr=19&amp;from=1205777&amp;fromto=1205777+1228430&amp;tab=0
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Professional guidelines
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-------------------------------------------------------------------------------------------------
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Professional guideline
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    ACMG 2013       
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        The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in STK11 that are pathogenic or expected to be pathogenic.
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            Guideline(http://www.acmg.net/docs/ACMG_Releases_Highly-Anticipated_Recommendations_on_Incidental_Findings_in_Clinical_Exome_and_Genome_Sequencing.pdf)
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            PubMed(/pubmed/23788249)
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Associated conditions
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-------------------------------------------------------------------------------------------------
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Description Tests
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-------------------------------------------------------------------------------------------------
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Carcinoma of pancreas
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    MedGen: C0235974 OMIM:  260350 GeneReviews: <span>Not available</span>  
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Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
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    GeneReviews: <span>Not available</span> 
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Genome-wide association study of Alzheimer's disease with psychotic symptoms.
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    GeneReviews: <span>Not available</span> 
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Germ cell tumor of testis
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    MedGen: C1336708 OMIM:  273300 GeneReviews: <span>Not available</span>  
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Melanoma, cutaneous malignant, susceptibility to, 1
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    MedGen: C1835047 OMIM:  155600 GeneReviews: <span>Not available</span>  
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Peutz-Jeghers syndrome
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    MedGen: C0031269 OMIM:  175200 GeneReviews: Peutz-Jeghers Syndrome  
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Copy number response
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-------------------------------------------------------------------------------------------------
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Copy number response
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    Triplosensitivity       
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        No evidence available (Last evaluated 2021-11-10)
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            ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=STK11)Haploinsufficency     
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        Sufficient evidence for dosage pathogenicity (Last evaluated 2021-11-10)
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            ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=STK11)
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            PubMed(/pubmed/20623358,23892522,2563227,28231849)</pre>
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VARIATION
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-------------------------------------------------------------------------------------------------
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See variants in ClinVar, http://130.14.22.58/sites/gene/clinvar/?term=STK11[gene]
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See studies and variants in dbVar, http://130.14.22.58/sites/gene
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See Variation Viewer (GRCh37.p13), http://130.14.22.58/sites/gene/variation/view/?q=6794[geneid]&amp;assm=GCF_000001405.25
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See Variation Viewer (GRCh38), http://130.14.22.58/sites/gene/variation/view/?q=6794[geneid]<pre/><pre>
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Genotypes
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    See  SNP Geneview Report, http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2FSNP%2Fsnp_ref.cgi%3FlocusId%3D6794
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    See 1000 Genomes Browser (GCF_000001405.25), http://130.14.22.58/sites/gene/variation/tools/1000genomes/?q=6794[geneid]&amp;assm=GCF_000001405.25</pre>
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INTERACTION
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-------------------------------------------------------------------------------------------------
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Description of Gene Interaction table
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Product     Interactant Other Gene    Complex   Source      Pubs
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-------------------------------------------------------------------------------------------------
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LKB1 phosphorylates MARK4.
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NP_000446.1     NP_113605.2     MARK4           BIND        PMID: 14676191
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LKB1 interacts with AMPK-alpha.
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NP_000446.1     NP_006243.2     PRKAA2          BIND        PMID: 14985505
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LKB1 autophosphorylates itself.
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NP_000446.1     NP_000446.1     STK11           BIND        PMID: 14676191
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LKB1 phosphorylates PAPK.
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NP_000446.1     NP_061041.2     STRADB          BIND        PMID: 14676191
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Q15831          Q13315          ATM             HPRD        PMID: 12234250,11853558
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Q15831          Q9Y376          CAB39           HPRD        PMID: 14676191
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Q15831          Q16543          CDC37           HPRD        PMID: 12489981
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Q15831          Q9P0L2          MARK1           HPRD        PMID: 14976552,14517247
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Q15831          Q7KZI7          MARK2           HPRD        PMID: 14976552
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Q15831          Q96L34          MARK4           HPRD        PMID: 14676191
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Q15831          Q9Y3A3          MOB4            HPRD        PMID: 16169070
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Q15831          Q8TEW0          PARD3           HPRD        PMID: 14676191
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Q15831          P54646          PRKAA2          HPRD        PMID: 10642499
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Q15831          P17612          PRKACA          HPRD        PMID: 11853558,11297520
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Q15831          P60484          PTEN            HPRD        PMID: 15987703
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Q15831          P51812          RPS6KA3         HPRD        PMID: 11853558,11297520
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Q15831          O75582          RPS6KA5         HPRD        PMID: 11297520
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Q15831          P23443          RPS6KB1         HPRD        PMID: 11853558,11297520
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Q15831          P51532          SMARCA4         HPRD        PMID: 11445556
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Q15831          Q9NRH2          SNRK            HPRD        PMID: 15733851
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Q15831          Q15831          STK11           HPRD        PMID: 11668633
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Q15831          LKB1 interacting protein 1  STK11IP         HPRD        PMID: 11741830
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Q15831          Protein kinase LYK5 STRADA          HPRD        PMID: 12805220
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Q15831          Q9C0K7          STRADB          HPRD        PMID: 14676191
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Q15831          TNFAIP3 interacting protein 2   TNIP2           HPRD        PMID: 12595760
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Q15831          P04637          TP53            HPRD        PMID: 11430832
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Affinity Capture-MS
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BioGRID:112670  BioGRID:126860  A2ML1           BioGRID     PMID: 33961781
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FRET
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BioGRID:112670  BioGRID:131028  ABCB5           BioGRID     PMID: 28205554
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Affinity Capture-MS
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BioGRID:112670  BioGRID:116784  ABRAXAS2        BioGRID     PMID: 33961781,28514442
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Two-hybrid
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BioGRID:112670  BioGRID:119283  ADIPOR1         BioGRID     PMID: 25640309
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Affinity Capture-MS
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BioGRID:112670  BioGRID:120419  AGGF1           BioGRID     PMID: 33961781
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Affinity Capture-MS
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BioGRID:112670  BioGRID:124393  AJUBA           BioGRID     PMID: 34591612
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Affinity Capture-MS
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BioGRID:112670  BioGRID:115445  AKAP9           BioGRID     PMID: 33961781
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FRET; Two-hybrid
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BioGRID:112670  BioGRID:106710  AKT1            BioGRID     PMID: 28205554,24412244
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Affinity Capture-MS
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BioGRID:112670  BioGRID:111790  ALDH18A1        BioGRID     PMID: 34591612
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Two-hybrid
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BioGRID:112670  BioGRID:106730  ALDOB           BioGRID     PMID: 24412244
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Affinity Capture-MS
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BioGRID:112670  BioGRID:106775  AMY1C           BioGRID     PMID: 33961781
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Two-hybrid
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BioGRID:112670  BioGRID:115795  ANP32B          BioGRID     PMID: 24412244
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Affinity Capture-MS
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BioGRID:112670  BioGRID:106798  ANXA1           BioGRID     PMID: 33961781
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Affinity Capture-MS
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BioGRID:112670  BioGRID:575558  ANXA8           BioGRID     PMID: 33961781
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Affinity Capture-Western
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BioGRID:112670  BioGRID:107587  AP2M1           BioGRID     PMID: 20368287
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Reconstituted Complex
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BioGRID:112670  BioGRID:106848  APP             BioGRID     PMID: 21832049
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FRET
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BioGRID:112670  BioGRID:106864  ARAF            BioGRID     PMID: 28205554
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Two-hybrid
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BioGRID:112670  BioGRID:106879  ARG2            BioGRID     PMID: 25640309
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Negative Genetic
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BioGRID:112670  BioGRID:128219  ARID2           BioGRID     PMID: 35559673
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FRET
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BioGRID:112670  BioGRID:106898  ARNT            BioGRID     PMID: 28205554
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Negative Genetic
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BioGRID:112670  BioGRID:121948  ATG101          BioGRID     PMID: 35559673
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Phenotypic Suppression
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BioGRID:112670  BioGRID:115787  ATG7            BioGRID     PMID: 33226137
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Negative Genetic
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BioGRID:112670  BioGRID:122518  ATG9A           BioGRID     PMID: 35559673
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Affinity Capture-Western
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BioGRID:112670  BioGRID:106962  ATM             BioGRID     PMID: 15713674
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FRET
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BioGRID:112670  BioGRID:112666  AURKA           BioGRID     PMID: 28205554
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Two-hybrid
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BioGRID:112670  BioGRID:198131  Ap2m1           BioGRID     PMID: 20368287
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Affinity Capture-MS
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BioGRID:112670  BioGRID:118855  BABAM1          BioGRID     PMID: 33961781
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Negative Genetic
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BioGRID:112670  BioGRID:113647  BAG6            BioGRID     PMID: 35559673
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Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
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BioGRID:112670  BioGRID:113911  BAP1            BioGRID     PMID: 32819560
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Two-hybrid
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BioGRID:112670  BioGRID:120182  BCAS3           BioGRID     PMID: 25640309
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Negative Genetic
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BioGRID:112670  BioGRID:115118  BCLAF1          BioGRID     PMID: 35559673
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FRET
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BioGRID:112670  BioGRID:114226  BECN1           BioGRID     PMID: 28205554
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Negative Genetic
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BioGRID:112670  BioGRID:121521  BIRC6           BioGRID     PMID: 35559673
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Affinity Capture-MS
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BioGRID:112670  BioGRID:126647  BPIFA2          BioGRID     PMID: 33961781
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Affinity Capture-MS
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BioGRID:112670  BioGRID:123248  BPIFB2          BioGRID     PMID: 33961781
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FRET
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BioGRID:112670  BioGRID:107141  BRAF            BioGRID     PMID: 28205554
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Negative Genetic
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BioGRID:112670  BioGRID:122599  BRCC3           BioGRID     PMID: 35559673
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Negative Genetic
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BioGRID:112670  BioGRID:122430  BRD9            BioGRID     PMID: 35559673
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Negative Genetic
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BioGRID:112670  BioGRID:123841  BRIP1           BioGRID     PMID: 35559673
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Negative Genetic
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BioGRID:112670  BioGRID:107160  BTK             BioGRID     PMID: 35559673
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Affinity Capture-MS
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BioGRID:112670  BioGRID:126409  C5orf24         BioGRID     PMID: 33961781,28514442
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Affinity Capture-MS
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BioGRID:112670  BioGRID:131603  C6orf58         BioGRID     PMID: 33961781
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Negative Genetic
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BioGRID:112670  BioGRID:124367  C8orf76         BioGRID     PMID: 35559673
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Affinity Capture-MS
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BioGRID:112670  BioGRID:107220  CA6             BioGRID     PMID: 33961781
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Affinity Capture-MS; Affinity Capture-Western; Co-localization
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BioGRID:112670  BioGRID:119696  CAB39           BioGRID     PMID: 35271311,34591612,33961781,32707033,31554794,31217475,28514442,25852190,25241761,20562859,15561763,14676191
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Affinity Capture-MS
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BioGRID:112670  BioGRID:123552  CAB39L          BioGRID     PMID: 33961781,28514442,26186194,20562859
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Two-hybrid
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BioGRID:112670  BioGRID:107256  CALM2           BioGRID     PMID: 25640309
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Negative Genetic
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BioGRID:112670  BioGRID:127632  CAMSAP1         BioGRID     PMID: 35559673
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FRET
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BioGRID:112670  BioGRID:117156  CBLC            BioGRID     PMID: 28205554
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Affinity Capture-MS
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BioGRID:112670  BioGRID:122267  CCDC136         BioGRID     PMID: 25852190
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Two-hybrid
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BioGRID:112670  BioGRID:1527673 CCDC180         BioGRID     PMID: 24412244
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FRET
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BioGRID:112670  BioGRID:107334  CCND2           BioGRID     PMID: 28205554
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FRET
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BioGRID:112670  BioGRID:107338  CCNE1           BioGRID     PMID: 28205554
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FRET
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BioGRID:112670  BioGRID:107398  CD44            BioGRID     PMID: 28205554
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Two-hybrid
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BioGRID:112670  BioGRID:114125  CDC14B          BioGRID     PMID: 24412244
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Affinity Capture-MS; Affinity Capture-Western
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BioGRID:112670  BioGRID:116312  CDC37           BioGRID     PMID: 34591612,33961781,32707033,21860411,20562859,14676191,14668798
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FRET
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BioGRID:112670  BioGRID:107454  CDK4            BioGRID     PMID: 28205554
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FRET
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BioGRID:112670  BioGRID:107456  CDK6            BioGRID     PMID: 28205554
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FRET
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BioGRID:112670  BioGRID:107463  CDKN2A          BioGRID     PMID: 28205554
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FRET
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BioGRID:112670  BioGRID:107464  CDKN2B          BioGRID     PMID: 28205554
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FRET
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BioGRID:112670  BioGRID:107465  CDKN2C          BioGRID     PMID: 28205554
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Two-hybrid
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BioGRID:112670  BioGRID:107500  CFL2            BioGRID     PMID: 25640309
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Affinity Capture-MS
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BioGRID:112670  BioGRID:114729  COPS2           BioGRID     PMID: 34591612,32707033
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Affinity Capture-MS
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BioGRID:112670  BioGRID:114103  COPS3           BioGRID     PMID: 34591612,33961781,32707033,25852190
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Affinity Capture-MS
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BioGRID:112670  BioGRID:119324  COPS4           BioGRID     PMID: 34591612,32707033,25852190
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Affinity Capture-MS; Affinity Capture-Western
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BioGRID:112670  BioGRID:116183  COPS5           BioGRID     PMID: 34591612,30710502
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Affinity Capture-MS
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BioGRID:112670  BioGRID:116176  COPS6           BioGRID     PMID: 34591612,32707033
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Affinity Capture-MS
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BioGRID:112670  BioGRID:119130  COPS7A          BioGRID     PMID: 34591612
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Affinity Capture-MS
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BioGRID:112670  BioGRID:122237  COPS7B          BioGRID     PMID: 34591612
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Affinity Capture-MS
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BioGRID:112670  BioGRID:116124  COPS8           BioGRID     PMID: 34591612,32707033
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Affinity Capture-MS
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BioGRID:112670  BioGRID:119069  CRNN            BioGRID     PMID: 33961781
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Two-hybrid
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BioGRID:112670  BioGRID:107798  CRY2            BioGRID     PMID: 25640309
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Negative Genetic
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BioGRID:112670  BioGRID:107836  CSNK1A1         BioGRID     PMID: 35559673
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Synthetic Lethality
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BioGRID:112670  BioGRID:107841  CSNK2A1         BioGRID     PMID: 27453043
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Affinity Capture-MS
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BioGRID:112670  BioGRID:107851  CST1            BioGRID     PMID: 33961781
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Affinity Capture-MS
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BioGRID:112670  BioGRID:107852  CST2            BioGRID     PMID: 33961781
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Affinity Capture-MS
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BioGRID:112670  BioGRID:107854  CST4            BioGRID     PMID: 33961781
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Two-hybrid
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BioGRID:112670  BioGRID:107888  CTSB            BioGRID     PMID: 25640309
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Affinity Capture-MS
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BioGRID:112670  BioGRID:114031  CUL2            BioGRID     PMID: 34591612
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Affinity Capture-MS
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BioGRID:112670  BioGRID:114028  CUL4B           BioGRID     PMID: 32707033
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Affinity Capture-MS
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BioGRID:112670  BioGRID:115159  CUL7            BioGRID     PMID: 33961781
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Two-hybrid
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BioGRID:112670  BioGRID:107919  CYLC2           BioGRID     PMID: 24412244
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Two-hybrid
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BioGRID:112670  BioGRID:107958  CYP17A1         BioGRID     PMID: 25640309
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Two-hybrid
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BioGRID:112670  BioGRID:608722  D2HGDH          BioGRID     PMID: 25640309
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FRET
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BioGRID:112670  BioGRID:107972  DACH1           BioGRID     PMID: 28205554
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Negative Genetic
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BioGRID:112670  BioGRID:121945  DHX35           BioGRID     PMID: 35559673
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Affinity Capture-MS
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BioGRID:112670  BioGRID:108095  DMBT1           BioGRID     PMID: 33961781
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Negative Genetic
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BioGRID:112670  BioGRID:108112  DNASE1          BioGRID     PMID: 35559673
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Negative Genetic
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BioGRID:112670  BioGRID:125472  DNTTIP1         BioGRID     PMID: 35559673
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Affinity Capture-MS
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BioGRID:112670  BioGRID:108164  DSG3            BioGRID     PMID: 33961781
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Affinity Capture-MS
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BioGRID:112670  BioGRID:108189  DVL2            BioGRID     PMID: 28514442
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Two-hybrid
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BioGRID:112670  BioGRID:108238  EEF1A2          BioGRID     PMID: 25640309
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Affinity Capture-Western
345
BioGRID:112670  BioGRID:108286  EIF2B1          BioGRID     PMID: 20368287
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Affinity Capture-MS
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BioGRID:112670  BioGRID:114423  ENDOU           BioGRID     PMID: 33961781
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FRET
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BioGRID:112670  BioGRID:108288  EPHA2           BioGRID     PMID: 28205554
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FRET
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BioGRID:112670  BioGRID:108376  ERBB2           BioGRID     PMID: 28205554
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Two-hybrid
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BioGRID:112670  BioGRID:118096  ERLEC1          BioGRID     PMID: 25640309
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Affinity Capture-Western; Biochemical Activity; Two-hybrid
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BioGRID:112670  BioGRID:108419  ETV4            BioGRID     PMID: 21150337,16912160
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Affinity Capture-MS
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BioGRID:112670  BioGRID:108426  EVPL            BioGRID     PMID: 33961781
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Two-hybrid
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BioGRID:112670  BioGRID:229070  Eif2b1          BioGRID     PMID: 20368287
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Two-hybrid
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BioGRID:112670  BioGRID:116659  FAIM2           BioGRID     PMID: 25640309
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Negative Genetic
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BioGRID:112670  BioGRID:123086  FAM106A         BioGRID     PMID: 35559673
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Negative Genetic
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BioGRID:112670  BioGRID:108472  FANCA           BioGRID     PMID: 35559673
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Negative Genetic
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BioGRID:112670  BioGRID:108483  FANCF           BioGRID     PMID: 35559673
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Two-hybrid
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BioGRID:112670  BioGRID:108497  FBP1            BioGRID     PMID: 24412244
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Two-hybrid
371
BioGRID:112670  BioGRID:114317  FBP2            BioGRID     PMID: 24412244
372
Affinity Capture-Western
373
BioGRID:112670  BioGRID:126870  FBXL14          BioGRID     PMID: 29601127
374
Affinity Capture-Western; Co-localization
375
BioGRID:112670  BioGRID:117649  FBXO22          BioGRID     PMID: 31217475
376
Negative Genetic
377
BioGRID:112670  BioGRID:127320  FBXO41          BioGRID     PMID: 35559673
378
Negative Genetic
379
BioGRID:112670  BioGRID:119962  FBXO42          BioGRID     PMID: 35559673
380
Negative Genetic
381
BioGRID:112670  BioGRID:116887  FBXW11          BioGRID     PMID: 35559673
382
Affinity Capture-MS
383
BioGRID:112670  BioGRID:117645  FBXW8           BioGRID     PMID: 33961781
384
FRET
385
BioGRID:112670  BioGRID:108555  FGFR4           BioGRID     PMID: 28205554
386
Affinity Capture-MS
387
BioGRID:112670  BioGRID:108578  FKBP4           BioGRID     PMID: 34591612
388
Affinity Capture-MS
389
BioGRID:112670  BioGRID:108579  FKBP5           BioGRID     PMID: 34591612,33961781,32707033,28514442,25852190,20562859,14676191
390
Affinity Capture-MS
391
BioGRID:112670  BioGRID:108601  FLG             BioGRID     PMID: 33961781
392
Affinity Capture-MS
393
BioGRID:112670  BioGRID:122669  FYCO1           BioGRID     PMID: 33961781
394
FRET
395
BioGRID:112670  BioGRID:119489  FZR1            BioGRID     PMID: 28205554
396
Affinity Capture-MS
397
BioGRID:112670  BioGRID:108887  GARS1           BioGRID     PMID: 34591612
398
Affinity Capture-MS
399
BioGRID:112670  BioGRID:127864  GBP6            BioGRID     PMID: 33961781
400
FRET
401
BioGRID:112670  BioGRID:124182  GLIS2           BioGRID     PMID: 28205554
402
Two-hybrid
403
BioGRID:112670  BioGRID:115325  GNPDA1          BioGRID     PMID: 25640309
404
Affinity Capture-MS
405
BioGRID:112670  BioGRID:109131  GPS1            BioGRID     PMID: 34591612,32707033
406
FRET
407
BioGRID:112670  BioGRID:109168  GRM1            BioGRID     PMID: 28205554
408
Affinity Capture-Western
409
BioGRID:112670  BioGRID:109187  GSK3B           BioGRID     PMID: 22270359
410
Negative Genetic
411
BioGRID:112670  BioGRID:114937  GTPBP1          BioGRID     PMID: 35559673
412
Negative Genetic
413
BioGRID:112670  BioGRID:120097  GTPBP2          BioGRID     PMID: 35559673
414
Affinity Capture-MS
415
BioGRID:112670  BioGRID:109268  H2AX            BioGRID     PMID: 25852190
416
Affinity Capture-MS
417
BioGRID:112670  BioGRID:109284  HAL             BioGRID     PMID: 33961781
418
Affinity Capture-Western; Biochemical Activity
419
BioGRID:112670  BioGRID:114438  HERC2           BioGRID     PMID: 27259994
420
FRET
421
BioGRID:112670  BioGRID:109330  HGF             BioGRID     PMID: 28205554
422
FRET
423
BioGRID:112670  BioGRID:109338  HIF1A           BioGRID     PMID: 28205554
424
Affinity Capture-MS
425
BioGRID:112670  BioGRID:109345  HK1             BioGRID     PMID: 34591612
426
Negative Genetic
427
BioGRID:112670  BioGRID:109465  HOXC9           BioGRID     PMID: 35559673
428
Two-hybrid
429
BioGRID:112670  BioGRID:109501  HRAS            BioGRID     PMID: 24412244
430
Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western
431
BioGRID:112670  BioGRID:109552  HSP90AA1        BioGRID     PMID: 33961781,32707033,28514442,22939624,21860411,14676191,14668798
432
Affinity Capture-MS
433
BioGRID:112670  BioGRID:109555  HSP90AA4P       BioGRID     PMID: 33961781,28514442
434
Affinity Capture-MS
435
BioGRID:112670  BioGRID:610599  HSP90AA5P       BioGRID     PMID: 33961781,28514442
436
Affinity Capture-MS
437
BioGRID:112670  BioGRID:109558  HSP90AB1        BioGRID     PMID: 33961781,32707033,28514442
438
Affinity Capture-MS
439
BioGRID:112670  BioGRID:109559  HSP90AB3P       BioGRID     PMID: 33961781,28514442
440
Affinity Capture-MS
441
BioGRID:112670  BioGRID:576430  HSP90AB4P       BioGRID     PMID: 33961781,28514442
442
Affinity Capture-MS
443
BioGRID:112670  BioGRID:109535  HSPA1A          BioGRID     PMID: 14676191
444
Affinity Capture-MS
445
BioGRID:112670  BioGRID:118149  HTATSF1         BioGRID     PMID: 33961781
446
Affinity Capture-MS
447
BioGRID:112670  BioGRID:120824  IARS2           BioGRID     PMID: 34591612
448
Two-hybrid
449
BioGRID:112670  BioGRID:109707  IGFBP3          BioGRID     PMID: 24412244
450
Affinity Capture-MS
451
BioGRID:112670  BioGRID:109714  IGHA1           BioGRID     PMID: 33961781
452
Affinity Capture-MS
453
BioGRID:112670  BioGRID:109715  IGHA2           BioGRID     PMID: 33961781
454
Negative Genetic
455
BioGRID:112670  BioGRID:114089  IKBKG           BioGRID     PMID: 35559673
456
Affinity Capture-MS
457
BioGRID:112670  BioGRID:109772  IL1RN           BioGRID     PMID: 33961781
458
Affinity Capture-MS
459
BioGRID:112670  BioGRID:129701  INO80E          BioGRID     PMID: 33961781
460
Affinity Capture-MS
461
BioGRID:112670  BioGRID:109916  IVD             BioGRID     PMID: 34591612,28514442
462
Affinity Capture-MS
463
BioGRID:112670  BioGRID:109917  IVL             BioGRID     PMID: 33961781
464
Affinity Capture-MS
465
BioGRID:112670  BioGRID:109732  JCHAIN          BioGRID     PMID: 33961781
466
Negative Genetic
467
BioGRID:112670  BioGRID:116105  JTB             BioGRID     PMID: 35559673
468
FRET
469
BioGRID:112670  BioGRID:108918  KAT2A           BioGRID     PMID: 28205554
470
FRET
471
BioGRID:112670  BioGRID:116204  KDELR2          BioGRID     PMID: 28205554
472
Affinity Capture-MS
473
BioGRID:112670  BioGRID:115035  KDM4A           BioGRID     PMID: 33961781,28514442
474
Affinity Capture-MS
475
BioGRID:112670  BioGRID:114873  KIF23           BioGRID     PMID: 14676191
476
Affinity Capture-MS
477
BioGRID:112670  BioGRID:111636  KLK10           BioGRID     PMID: 33961781
478
Two-hybrid
479
BioGRID:112670  BioGRID:111631  KLK7            BioGRID     PMID: 25640309
480
Negative Genetic
481
BioGRID:112670  BioGRID:110038  KPNA4           BioGRID     PMID: 35559673
482
Affinity Capture-Western
483
BioGRID:112670  BioGRID:120336  LAMTOR1         BioGRID     PMID: 34821530
484
FRET
485
BioGRID:112670  BioGRID:117727  LATS2           BioGRID     PMID: 28205554
486
Two-hybrid
487
BioGRID:112670  BioGRID:119354  LEF1            BioGRID     PMID: 24412244
488
Affinity Capture-MS
489
BioGRID:112670  BioGRID:110175  LIMS1           BioGRID     PMID: 14676191
490
Affinity Capture-MS
491
BioGRID:112670  BioGRID:110201  LOXL2           BioGRID     PMID: 34591612
492
Affinity Capture-MS
493
BioGRID:112670  BioGRID:110208  LPP             BioGRID     PMID: 34591612
494
Affinity Capture-MS
495
BioGRID:112670  BioGRID:110235  LTF             BioGRID     PMID: 33961781
496
Two-hybrid
497
BioGRID:112670  BioGRID:117985  LYPD3           BioGRID     PMID: 25640309
498
Affinity Capture-MS
499
BioGRID:112670  BioGRID:110247  LYZ             BioGRID     PMID: 33961781
500
Negative Genetic
501
BioGRID:112670  BioGRID:116348  LZTS1           BioGRID     PMID: 35559673
502
Synthetic Lethality; Two-hybrid
503
BioGRID:112670  BioGRID:111590  MAP2K1          BioGRID     PMID: 27453043,24412244
504
Affinity Capture-Western; FRET
505
BioGRID:112670  BioGRID:111592  MAP2K3          BioGRID     PMID: 28628118,28205554
506
FRET
507
BioGRID:112670  BioGRID:111593  MAP2K5          BioGRID     PMID: 28205554
508
FRET
509
BioGRID:112670  BioGRID:111594  MAP2K6          BioGRID     PMID: 28205554
510
FRET
511
BioGRID:112670  BioGRID:110381  MAP3K5          BioGRID     PMID: 28205554
512
FRET
513
BioGRID:112670  BioGRID:107819  MAPK14          BioGRID     PMID: 28205554
514
Two-hybrid
515
BioGRID:112670  BioGRID:111581  MAPK3           BioGRID     PMID: 24412244
516
Two-hybrid
517
BioGRID:112670  BioGRID:116581  MAPRE1          BioGRID     PMID: 24552808
518
Biochemical Activity
519
BioGRID:112670  BioGRID:108326  MARK2           BioGRID     PMID: 16396636
520
Affinity Capture-Western
521
BioGRID:112670  BioGRID:121760  MARK4           BioGRID     PMID: 14676191
522
Negative Genetic
523
BioGRID:112670  BioGRID:129033  MCM9            BioGRID     PMID: 35559673
524
Affinity Capture-Western; FRET
525
BioGRID:112670  BioGRID:110358  MDM2            BioGRID     PMID: 35513074,28205554
526
FRET
527
BioGRID:112670  BioGRID:110391  MET             BioGRID     PMID: 28205554
528
Affinity Capture-MS
529
BioGRID:112670  BioGRID:119275  MLXIPL          BioGRID     PMID: 34461288
530
Affinity Capture-MS; Co-localization
531
BioGRID:112670  BioGRID:122103  MMS19           BioGRID     PMID: 34591612
532
Two-hybrid
533
BioGRID:112670  BioGRID:110481  MOCS2           BioGRID     PMID: 25640309
534
Affinity Capture-MS
535
BioGRID:112670  BioGRID:110493  MPO             BioGRID     PMID: 33961781
536
Negative Genetic
537
BioGRID:112670  BioGRID:110498  MPV17           BioGRID     PMID: 35559673
538
Negative Genetic
539
BioGRID:112670  BioGRID:125820  MTFMT           BioGRID     PMID: 35559673
540
Affinity Capture-MS
541
BioGRID:112670  BioGRID:114560  MTMR4           BioGRID     PMID: 33961781
542
Affinity Capture-MS
543
BioGRID:112670  BioGRID:608337  MUC5B           BioGRID     PMID: 33961781
544
Affinity Capture-MS
545
BioGRID:112670  BioGRID:110676  MUC7            BioGRID     PMID: 33961781
546
FRET
547
BioGRID:112670  BioGRID:110694  MYC             BioGRID     PMID: 28205554
548
Two-hybrid
549
BioGRID:112670  BioGRID:119921  NANS            BioGRID     PMID: 24412244
550
Two-hybrid
551
BioGRID:112670  BioGRID:106528  NAT2            BioGRID     PMID: 25640309
552
Two-hybrid
553
BioGRID:112670  BioGRID:110632  ND2             BioGRID     PMID: 25640309
554
Negative Genetic
555
BioGRID:112670  BioGRID:110792  NDUFB6          BioGRID     PMID: 35559673
556
Affinity Capture-MS
557
BioGRID:112670  BioGRID:114594  NEMF            BioGRID     PMID: 28514442
558
Affinity Capture-MS
559
BioGRID:112670  BioGRID:115983  NES             BioGRID     PMID: 33961781
560
FRET
561
BioGRID:112670  BioGRID:110844  NF2             BioGRID     PMID: 28205554
562
Negative Genetic
563
BioGRID:112670  BioGRID:117008  OTP             BioGRID     PMID: 35559673
564
Affinity Capture-MS
565
BioGRID:112670  BioGRID:116413  PACSIN2         BioGRID     PMID: 33961781
566
FRET
567
BioGRID:112670  BioGRID:111182  PDGFRA          BioGRID     PMID: 28205554
568
Negative Genetic
569
BioGRID:112670  BioGRID:116848  PDS5A           BioGRID     PMID: 35559673
570
Negative Genetic
571
BioGRID:112670  BioGRID:117125  PDSS1           BioGRID     PMID: 35559673
572
Two-hybrid
573
BioGRID:112670  BioGRID:121330  PDXP            BioGRID     PMID: 25640309
574
Affinity Capture-MS
575
BioGRID:112670  BioGRID:111788  PEX5            BioGRID     PMID: 33961781
576
Two-hybrid
577
BioGRID:112670  BioGRID:122561  PHF23           BioGRID     PMID: 25640309
578
Affinity Capture-MS
579
BioGRID:112670  BioGRID:111302  PIGR            BioGRID     PMID: 33961781
580
FRET
581
BioGRID:112670  BioGRID:111308  PIK3CA          BioGRID     PMID: 28205554
582
Affinity Capture-MS
583
BioGRID:112670  BioGRID:111322  PIP4K2A         BioGRID     PMID: 33961781,32707033,28514442
584
Affinity Capture-MS
585
BioGRID:112670  BioGRID:113985  PIP4K2B         BioGRID     PMID: 32707033
586
Affinity Capture-MS
587
BioGRID:112670  BioGRID:122928  PIP4K2C         BioGRID     PMID: 33961781
588
Affinity Capture-MS
589
BioGRID:112670  BioGRID:114074  PKP4            BioGRID     PMID: 34591612
590
Two-hybrid
591
BioGRID:112670  BioGRID:117173  PLD3            BioGRID     PMID: 25640309
592
Affinity Capture-MS
593
BioGRID:112670  BioGRID:126828  PLEKHA7         BioGRID     PMID: 34591612
594
Affinity Capture-MS
595
BioGRID:112670  BioGRID:123048  POF1B           BioGRID     PMID: 33961781
596
Affinity Capture-MS
597
BioGRID:112670  BioGRID:111488  PPL             BioGRID     PMID: 33961781
598
Two-hybrid
599
BioGRID:112670  BioGRID:111508  PPP2CB          BioGRID     PMID: 24412244
600
Negative Genetic
601
BioGRID:112670  BioGRID:120344  PPP2R3C         BioGRID     PMID: 35559673
602
Affinity Capture-Western; Biochemical Activity; Two-hybrid
603
BioGRID:112670  BioGRID:111549  PRKAA1          BioGRID     PMID: 31995728,31217475,16912160
604
Co-localization
605
BioGRID:112670  BioGRID:111550  PRKAA2          BioGRID     PMID: 25241761
606
Co-localization
607
BioGRID:112670  BioGRID:111558  PRKAG1          BioGRID     PMID: 31983282
608
Negative Genetic
609
BioGRID:112670  BioGRID:114143  PRKRA           BioGRID     PMID: 35559673
610
Two-hybrid
611
BioGRID:112670  BioGRID:118887  PRSS50          BioGRID     PMID: 25640309
612
Affinity Capture-MS
613
BioGRID:112670  BioGRID:111638  PRTN3           BioGRID     PMID: 33961781
614
Negative Genetic
615
BioGRID:112670  BioGRID:114872  PSMF1           BioGRID     PMID: 35559673
616
Affinity Capture-Western; Biochemical Activity; Co-localization; Two-hybrid
617
BioGRID:112670  BioGRID:111700  PTEN            BioGRID     PMID: 15987703
618
Two-hybrid
619
BioGRID:112670  BioGRID:111856  RASA1           BioGRID     PMID: 24412244
620
FRET
621
BioGRID:112670  BioGRID:116356  RASSF1          BioGRID     PMID: 28205554
622
Two-hybrid
623
BioGRID:112670  BioGRID:116828  RHOBTB2         BioGRID     PMID: 25640309
624
Affinity Capture-MS
625
BioGRID:112670  BioGRID:121946  RIC8A           BioGRID     PMID: 34591612
626
Affinity Capture-RNA
627
BioGRID:112670  BioGRID:117121  RIGI            BioGRID     PMID: 32513696
628
Affinity Capture-MS
629
BioGRID:112670  BioGRID:120896  RIOK2           BioGRID     PMID: 33961781
630
Affinity Capture-Western
631
BioGRID:112670  BioGRID:123598  RNF146          BioGRID     PMID: 31554794
632
Affinity Capture-MS
633
BioGRID:112670  BioGRID:122783  RPAP3           BioGRID     PMID: 14676191
634
Negative Genetic
635
BioGRID:112670  BioGRID:121820  RPRD1B          BioGRID     PMID: 35559673
636
Co-localization
637
BioGRID:112670  BioGRID:112112  RPS6KB1         BioGRID     PMID: 25241761
638
Two-hybrid
639
BioGRID:112670  BioGRID:121504  S100A14         BioGRID     PMID: 25640309
640
Affinity Capture-MS
641
BioGRID:112670  BioGRID:112188  S100A9          BioGRID     PMID: 33961781
642
Affinity Capture-MS
643
BioGRID:112670  BioGRID:114324  SCEL            BioGRID     PMID: 33961781
644
Negative Genetic
645
BioGRID:112670  BioGRID:112291  SDHB            BioGRID     PMID: 35559673
646
Two-hybrid
647
BioGRID:112670  BioGRID:116015  SEPTIN9         BioGRID     PMID: 25640309
648
Affinity Capture-MS
649
BioGRID:112670  BioGRID:108307  SERPINB1        BioGRID     PMID: 33961781
650
Affinity Capture-MS
651
BioGRID:112670  BioGRID:111293  SERPINB13       BioGRID     PMID: 33961781
652
Affinity Capture-MS
653
BioGRID:112670  BioGRID:112223  SERPINB3        BioGRID     PMID: 33961781
654
Affinity Capture-MS
655
BioGRID:112670  BioGRID:112224  SERPINB4        BioGRID     PMID: 33961781
656
Affinity Capture-MS; Two-hybrid
657
BioGRID:112670  BioGRID:111286  SERPINB5        BioGRID     PMID: 33961781,25640309
658
Affinity Capture-MS
659
BioGRID:112670  BioGRID:118845  SETD2           BioGRID     PMID: 33961781
660
Biochemical Activity
661
BioGRID:112670  BioGRID:127260  SIK1            BioGRID     PMID: 16396636
662
Affinity Capture-Western; Biochemical Activity
663
BioGRID:112670  BioGRID:116983  SIRT1           BioGRID     PMID: 27259994,18687677
664
Negative Genetic
665
BioGRID:112670  BioGRID:124002  SLC25A33        BioGRID     PMID: 35559673
666
Negative Genetic
667
BioGRID:112670  BioGRID:115726  SLC30A9         BioGRID     PMID: 35559673
668
FRET
669
BioGRID:112670  BioGRID:110261  SMAD1           BioGRID     PMID: 28205554
670
Affinity Capture-MS; Affinity Capture-Western; FRET; Reconstituted Complex
671
BioGRID:112670  BioGRID:112481  SMARCA4         BioGRID     PMID: 28205554,14676191,11445556
672
Affinity Capture-MS
673
BioGRID:112670  BioGRID:112483  SMARCC1         BioGRID     PMID: 14676191
674
Affinity Capture-Western
675
BioGRID:112670  BioGRID:112499  SNAI1           BioGRID     PMID: 29601127
676
Biochemical Activity
677
BioGRID:112670  BioGRID:120211  SNRK            BioGRID     PMID: 15733851
678
Affinity Capture-MS
679
BioGRID:112670  BioGRID:119535  SNX9            BioGRID     PMID: 33961781
680
Negative Genetic
681
BioGRID:112670  BioGRID:119936  SOX18           BioGRID     PMID: 35559673
682
FRET
683
BioGRID:112670  BioGRID:112542  SOX4            BioGRID     PMID: 28205554
684
Two-hybrid
685
BioGRID:112670  BioGRID:117335  SPDEF           BioGRID     PMID: 16912160
686
Affinity Capture-MS
687
BioGRID:112670  BioGRID:112585  SPRR3           BioGRID     PMID: 33961781
688
Two-hybrid
689
BioGRID:112670  BioGRID:112645  ST14            BioGRID     PMID: 25640309
690
FRET
691
BioGRID:112670  BioGRID:112670  STK11           BioGRID     PMID: 28205554
692
Affinity Capture-Western
693
BioGRID:112670  BioGRID:125352  STK11IP         BioGRID     PMID: 11741830
694
Two-hybrid
695
BioGRID:112670  BioGRID:114011  STK24           BioGRID     PMID: 25640309
696
Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
697
BioGRID:112670  BioGRID:124934  STRADA          BioGRID     PMID: 35271311,34591612,33961781,32707033,31554794,28514442,25852190,25241761,21860411,20562859,15561763,14676191,12805220
698
Affinity Capture-MS; Biochemical Activity
699
BioGRID:112670  BioGRID:120668  STRADB          BioGRID     PMID: 35271311,34591612,33961781,32707033,28514442,20562859,14676191
700
Affinity Capture-Western
701
BioGRID:112670  BioGRID:115563  STUB1           BioGRID     PMID: 21860411
702
Two-hybrid
703
BioGRID:112670  BioGRID:120346  STX17           BioGRID     PMID: 24412244
704
Affinity Capture-MS
705
BioGRID:112670  BioGRID:112689  SULT2B1         BioGRID     PMID: 33961781
706
Affinity Capture-MS
707
BioGRID:112670  BioGRID:112697  SUPT5H          BioGRID     PMID: 33961781
708
Affinity Capture-MS
709
BioGRID:112670  BioGRID:112698  SUPT6H          BioGRID     PMID: 33961781
710
Two-hybrid
711
BioGRID:112670  BioGRID:120889  TBC1D23         BioGRID     PMID: 21516116
712
Two-hybrid
713
BioGRID:112670  BioGRID:116994  TDRD7           BioGRID     PMID: 24412244
714
FRET
715
BioGRID:112670  BioGRID:114041  TEAD2           BioGRID     PMID: 28205554
716
FRET
717
BioGRID:112670  BioGRID:112874  TERT            BioGRID     PMID: 28205554
718
Affinity Capture-MS
719
BioGRID:112670  BioGRID:112909  TGM1            BioGRID     PMID: 33961781
720
Affinity Capture-MS
721
BioGRID:112670  BioGRID:112911  TGM3            BioGRID     PMID: 33961781
722
Two-hybrid
723
BioGRID:112670  BioGRID:112921  THOP1           BioGRID     PMID: 25640309
724
Two-hybrid
725
BioGRID:112670  BioGRID:112925  THRSP           BioGRID     PMID: 25640309
726
FRET
727
BioGRID:112670  BioGRID:112986  TNFRSF1A        BioGRID     PMID: 28205554
728
Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
729
BioGRID:112670  BioGRID:122573  TNIP2           BioGRID     PMID: 27609421,12753905,12595760
730
Affinity Capture-Western
731
BioGRID:112670  BioGRID:114207  TNKS            BioGRID     PMID: 31554794
732
Affinity Capture-Western
733
BioGRID:112670  BioGRID:123257  TNKS2           BioGRID     PMID: 31554794
734
Affinity Capture-MS; Affinity Capture-Western; FRET
735
BioGRID:112670  BioGRID:113010  TP53            BioGRID     PMID: 33961781,28205554,11430832
736
Affinity Capture-Western
737
BioGRID:112670  BioGRID:114181  TP63            BioGRID     PMID: 21150337
738
Two-hybrid
739
BioGRID:112670  BioGRID:113500  TRIM25          BioGRID     PMID: 25640309
740
Two-hybrid
741
BioGRID:112670  BioGRID:119593  TRMO            BioGRID     PMID: 24412244
742
Negative Genetic
743
BioGRID:112670  BioGRID:113100  TSC2            BioGRID     PMID: 35559673
744
Two-hybrid
745
BioGRID:112670  BioGRID:113102  TSG101          BioGRID     PMID: 25640309
746
Two-hybrid
747
BioGRID:112670  BioGRID:113603  TUBA1A          BioGRID     PMID: 25640309
748
Two-hybrid
749
BioGRID:112670  BioGRID:115655  TUBB4A          BioGRID     PMID: 25640309
750
Negative Genetic
751
BioGRID:112670  BioGRID:113149  TYMS            BioGRID     PMID: 35559673
752
Biochemical Activity
753
BioGRID:112670  BioGRID:113170  UBE2D2          BioGRID     PMID: 21860411
754
Affinity Capture-Western
755
BioGRID:112670  BioGRID:121973  UBE2O           BioGRID     PMID: 31900314
756
Negative Genetic
757
BioGRID:112670  BioGRID:118858  UBE2T           BioGRID     PMID: 35559673
758
Affinity Capture-MS
759
BioGRID:112670  BioGRID:113866  USP11           BioGRID     PMID: 14676191
760
Two-hybrid
761
BioGRID:112670  BioGRID:112804  VPS72           BioGRID     PMID: 25640309
762
Affinity Capture-MS
763
BioGRID:112670  BioGRID:121649  WDR48           BioGRID     PMID: 19615732
764
Affinity Capture-Western
765
BioGRID:112670  BioGRID:116350  WDR6            BioGRID     PMID: 17216128
766
FRET
767
BioGRID:112670  BioGRID:113327  WT1             BioGRID     PMID: 28205554
768
Two-hybrid
769
BioGRID:112670  BioGRID:113344  XPA             BioGRID     PMID: 24412244
770
Negative Genetic
771
BioGRID:112670  BioGRID:119655  YPEL5           BioGRID     PMID: 35559673
772
FRET
773
BioGRID:112670  BioGRID:113364  YWHAG           BioGRID     PMID: 28205554
774
Affinity Capture-MS
775
BioGRID:112670  BioGRID:125855  ZG16B           BioGRID     PMID: 33961781
776
Two-hybrid
777
BioGRID:112670  BioGRID:113528  ZNF189          BioGRID     PMID: 24412244
778
Two-hybrid
779
BioGRID:112670  BioGRID:116536  ZNF510          BioGRID     PMID: 24412244
780
781
GENERAL GENE INFO
782
-------------------------------------------------------------------------------------------------
783
784
Marker
785
    REU1905                 (e-PCR) Links:UniSTS:257089
786
    RH104368                (e-PCR) Links:UniSTS:98693
787
    Stk11                   (e-PCR), detects polymorphism   Links:UniSTS:546518
788
789
790
Homology
791
    Homologs of the STK11 gene
792
        The STK11 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and frog.
793
    Orthologs from Annotation Pipeline (/gene/?Term=ortholog_gene_6794[group]): 
794
    Orthologs
795
796
Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
797
798
Function                      GO ID     Evidence
799
-------------------------------------------------------------------------------------------------
800
enables ATP binding                           GO:0000000    PMID: 12805220
801
enables LRR domain binding                    GO:0000000    -
802
enables magnesium ion binding                 GO:0000000    PMID: 12805220
803
enables p53 binding                           GO:0000000    PMID: 11430832
804
enables protein binding                       GO:0000000    PMID: 12595760,12753905,12805220,14676191,17216128,19274086,19513107,19892943,20562859,22575644,22939624,24362629,25036637,25241761,25329316,25852190,26479318,28514442,32707033,34591612
805
enables protein kinase activator activit...   GO:0000000    PMID: 19892943
806
enables protein serine kinase activity        GO:0000000    -
807
enables protein serine/threonine kinase ...   GO:0000000    PMID: 21873635
808
enables protein serine/threonine kinase ...   GO:0000000    PMID: 11430832,12805220,19892943
809
enables protein serine/threonine kinase ...   GO:0000000    -
810
enables protein-containing complex bindi...   GO:0000000    -
811
812
Processs                      GO ID     Evidence
813
-------------------------------------------------------------------------------------------------
814
involved_in DNA damage response               GO:0000000    PMID: 21873635
815
involved_in DNA damage response               GO:0000000    PMID: 25329316
816
acts_upstream_of_negative_effect G1 to G...   GO:0000000    PMID: 17216128
817
acts_upstream_of_negative_effect G1 to G...   GO:0000000    PMID: 12805220
818
involved_in Golgi localization                GO:0000000    -
819
involved_in T cell receptor signaling pa...   GO:0000000    -
820
involved_in activation of protein kinase...   GO:0000000    PMID: 19892943
821
involved_in activation of protein kinase...   GO:0000000    PMID: 15731909
822
involved_in activation of protein kinase...   GO:0000000    -
823
involved_in anoikis                           GO:0000000    PMID: 19622832
824
involved_in autophagy                         GO:0000000    -
825
involved_in axonogenesis                      GO:0000000    -
826
involved_in cellular response to UV-B         GO:0000000    PMID: 25329316
827
involved_in dendrite extension                GO:0000000    -
828
involved_in epithelial cell proliferatio...   GO:0000000    -
829
involved_in establishment of cell polari...   GO:0000000    PMID: 21873635
830
involved_in establishment of cell polari...   GO:0000000    PMID: 24643070
831
involved_in establishment of cell polari...   GO:0000000    -
832
involved_in glucose homeostasis               GO:0000000    -
833
involved_in intrinsic apoptotic signalin...   GO:0000000    PMID: 11430832
834
involved_in negative regulation of TORC1...   GO:0000000    PMID: 23878245
835
involved_in negative regulation of canon...   GO:0000000    PMID: 15731909
836
involved_in negative regulation of cell ...   GO:0000000    -
837
involved_in negative regulation of cell ...   GO:0000000    PMID: 17216128,25329316
838
involved_in negative regulation of cold-...   GO:0000000    PMID: 27461402
839
involved_in negative regulation of epith...   GO:0000000    -
840
involved_in peptidyl-threonine phosphory...   GO:0000000    PMID: 12805220
841
involved_in positive regulation of autop...   GO:0000000    PMID: 23878245
842
involved_in positive regulation of axono...   GO:0000000    -
843
involved_in positive regulation of gluco...   GO:0000000    -
844
involved_in positive regulation of prote...   GO:0000000    -
845
involved_in positive regulation of trans...   GO:0000000    PMID: 18311138
846
involved_in positive regulation of vesic...   GO:0000000    PMID: 21873635
847
involved_in positive regulation of vesic...   GO:0000000    PMID: 24643070
848
involved_in positive thymic T cell selec...   GO:0000000    -
849
involved_in protein autophosphorylation       GO:0000000    PMID: 11430832
850
involved_in protein dephosphorylation         GO:0000000    PMID: 15731909
851
involved_in protein localization to nucl...   GO:0000000    -
852
involved_in protein phosphorylation           GO:0000000    PMID: 21873635
853
involved_in protein phosphorylation           GO:0000000    PMID: 12805220,25329316
854
involved_in regulation of Wnt signaling ...   GO:0000000    PMID: 21873635
855
involved_in regulation of cell cycle          GO:0000000    -
856
involved_in regulation of cell growth         GO:0000000    -
857
involved_in regulation of dendrite morph...   GO:0000000    -
858
involved_in regulation of protein kinase...   GO:0000000    -
859
involved_in regulation of signal transdu...   GO:0000000    -
860
involved_in response to activity              GO:0000000    -
861
involved_in response to glucagon              GO:0000000    -
862
involved_in response to ionizing radiati...   GO:0000000    -
863
involved_in response to lipid                 GO:0000000    -
864
involved_in response to thyroid hormone       GO:0000000    -
865
involved_in signal transduction               GO:0000000    PMID: 21873635
866
involved_in spermatogenesis                   GO:0000000    -
867
involved_in tissue homeostasis                GO:0000000    -
868
involved_in vasculature development           GO:0000000    -
869
870
Component                     GO ID     Evidence
871
-------------------------------------------------------------------------------------------------
872
located_in Z disc                             GO:0000000    -
873
is_active_in cytoplasm                        GO:0000000    PMID: 21873635
874
located_in cytoplasm                          GO:0000000    PMID: 11430832,12805220,14517248,17216128,18854309
875
located_in cytoplasm                          GO:0000000    -
876
located_in cytosol                            GO:0000000    -
877
located_in cytosol                            GO:0000000    -
878
located_in cytosol                            GO:0000000    -
879
located_in extracellular exosome              GO:0000000    PMID: 19056867
880
part_of intracellular protein-containing...   GO:0000000    PMID: 12805220
881
located_in membrane                           GO:0000000    -
882
located_in mitochondrion                      GO:0000000    PMID: 11430832
883
located_in nucleoplasm                        GO:0000000    -
884
located_in nucleoplasm                        GO:0000000    -
885
is_active_in nucleus                          GO:0000000    PMID: 21873635
886
located_in nucleus                            GO:0000000    PMID: 12805220,18854309
887
part_of serine/threonine protein kinase ...   GO:0000000    PMID: 19892943
888
part_of serine/threonine protein kinase ...   GO:0000000    -
889
890
GENERAL PROTEIN INFORMATION
891
-------------------------------------------------------------------------------------------------
892
Preferred Names
893
    serine/threonine-protein kinase STK11
894
Names
895
    liver kinase B1
896
    polarization-related protein LKB1
897
    renal carcinoma antigen NY-REN-19
898
    serine/threonine-protein kinase 11
899
    serine/threonine-protein kinase LKB1
900
NP_000446.1
901
    EC 2.7.11.1
902
NP_001394184.1
903
    EC 2.7.11.1
904
905
NCBI REFERENCE SEQUENCES (RefSeq)
906
-------------------------------------------------------------------------------------------------
907
908
RefSeqs maintained independently of Annotated Genomes
909
910
These reference sequences exist independently of genome builds.
911
These reference sequences are curated independently of the genome annotation cycle, 
912
so their versions may not match the RefSeq versions in the current genome build. 
913
Identify version mismatches by comparing the version of the RefSeq in this section to 
914
the one reported in Genomic regions, transcripts, and products section above.
915
916
    Genomic
917
        NG_007460.2 RefSeqGene
918
        Range       21392..44028
919
        Download    GenBank FASTA Sequence Viewer (Graphics) 
920
921
922
923
    mRNA and Protein(s) 
924
925
    NM_000455.5 → NP_000446.1  REVIEWEDserine/threonine-protein kinase STK11 isoform 1
926
927
    See proteins identical to NP_000446.1 at http://130.14.22.58/ipg/NP_000446.1/
928
929
    Source sequence(s): AC011544, BC007981, BC019334, BM993274, BQ222023, BU174122, BU739451 
930
      Consensus CDS: CCDS45896.1
931
      UniProtKB/TrEMBL: A0A0S2Z4D1
932
      UniProtKB/Swiss-Prot: E7EW76
933
      UniProtKB/Swiss-Prot: Q15831
934
935
    Related Ensembl: ENSP00000324856.6, ENST00000326873.12
936
      Conserved Domains (1)summary
937
        cd14119: 
938
        Location:55 - 309
939
        STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
940
941
    NM_001407255.1 → NP_001394184.1  REVIEWEDserine/threonine-protein kinase STK11 isoform 2
942
    Source sequence(s): AC011544 
943
944
    RNA
945
946
        NR_176325.1 RNA Sequence
947
        Source sequence(s): AC004221, AC011544 
948
949
RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03
950
The following sections contain reference sequences that belong to a specific genome build. 
951
This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which 
952
this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both 
953
reference and alternate assemblies. Model RNAs and proteins are also reported here.
954
955
Reference GRCh38.p14 Primary Assembly
956
957
    Genomic
958
        NC_000019.10 Reference GRCh38.p14 Primary Assembly
959
        Range       1205777..1228430
960
        Download    GenBank FASTA Sequence Viewer (Graphics) 
961
962
Alternate T2T-CHM13v2.0
963
964
    Genomic
965
        NC_060943.1 Alternate T2T-CHM13v2.0
966
        Range       1174324..1196988
967
        Download    GenBank FASTA Sequence Viewer (Graphics) 
968
969
970
971
RELATED SEQUENCES
972
-------------------------------------------------------------------------------------------------
973
974
Nucleotide          Protein
975
-------------------------------------------------------------------------------------------------
976
genomic                     AC004221.2  AAF97257.1
977
genomic                     AC011544.6(26171..45903)    None
978
genomic                     AH005839.2  AAB97833.1
979
genomic                     AH006100.2  AAC15742.1
980
genomic                     CH471139.2  EAW69538.1
981
                EAW69539
982
                EAW69540
983
genomic                     CP068259.2(1174325..1196989)    None
984
mRNA                        AB209553.1  BAD92790.1
985
mRNA                        AF035625.1  AAC39527.1
986
mRNA                        AF217978.1  AAG17221.1
987
mRNA                        AJ844634.2  CAH59749.2
988
mRNA                        AK128518.1  None
989
mRNA                        AK314858.1  BAG37374.1
990
mRNA                        BC007981.2  AAH07981.1
991
mRNA                        BC019334.1  AAH19334.1
992
mRNA                        BM993274.1  None
993
mRNA                        BQ222023.1  None
994
mRNA                        BU174122.1  None
995
mRNA                        BU739451.1  None
996
mRNA                        EF644172.1  ABR45718.1
997
mRNA                        GU573916.1  ADD71158.1
998
mRNA                        KU178339.1  ALQ33797.1
999
mRNA                        KU178340.1  ALQ33798.1
1000
mRNA                        U63333.1    AAB05809.1
1001
1002
Protein Accession       Links
1003
-------------------------------------------------------------------------------------------------
1004
Q15831.1        GenPept(/protein/3024670)       UniProtKB/Swiss-Prot:Q15831
1005
1006
GENE LINKOUT
1007
-------------------------------------------------------------------------------------------------
1008
The following LinkOut(www.ncbi.nlm.nih.gov/projects/linkout/index.html) resources
1009
are supplied by external providers. These providers are responsible for
1010
maintaining the links.
1011
1012
Chemical Information
1013
  (Free resource) (free) Interologous Interaction Database
1014
    Interologous Interaction Database
1015
  (Order form) MilliporeSigma
1016
    Stk11 productsStk11 products
1017
  (Order form) Novus Biologicals
1018
    Peptides and ProteinsPeptides and ProteinsLysatesLysatesPrimary AntibodiesPrimary Antibodies
1019
1020
Medical
1021
  (Free resource) (free) MedlinePlus Health Information
1022
    STK11 geneSTK11 gene
1023
1024
Molecular Biology Databases
1025
  (Free resource) (free) Bgee database
1026
    STK11 gene expressionSTK11 gene expression
1027
  (Free resource) (free) BioGPS
1028
    BioGPS
1029
  (Free resource) (free) BioGRID Open Repository of CRISPR Screens (ORCS)
1030
    BioGRID CRISPR Screen Phenotypes (153 hits/1229 screens)BioGRID CRISPR Screen Phenotypes (153 hits/1229 screens)
1031
  (Free resource) (free) CREB Target Gene Database
1032
    CREB Target Gene Database
1033
  (Free resource) (Free registration required) (free) Creative Biogene
1034
    serine/threonine kinase 11serine/threonine kinase 11
1035
  (Free resource) (free) Eukaryotic Promoter Database
1036
    STK11_1STK11_1
1037
  (Free resource) (free) GenAge Database of Aging Related Genes
1038
    GenAge Database of Aging Related Genes
1039
  (Order form) GenScript latest version of gene cDNA ORF Clone
1040
    GenScript latest version of gene cDNA ORF Clone
1041
  (Free resource) (free) GeneNetwork
1042
    Records for gene expression in HumanRecords for gene expression in Human
1043
  (Free resource) (free) Genevisible
1044
    STK11STK11
1045
  (Free resource) (free) GlyGen glycoinformatics resource
1046
    GlyGen glycoinformatics resource
1047
  (Free resource) (free) Guide to Pharmacology
1048
    serine/threonine kinase 11 geneserine/threonine kinase 11 gene
1049
  (Free resource) (Free registration required) (free) Human Gene Mutation Database
1050
    Human Gene Mutation Database
1051
  (Free resource) (free) Human eFP Browser
1052
    Human eFP BrowserHuman eFP BrowserHuman eFP Browser
1053
  Ingenuity Pathways Analysis
1054
    Ingenuity Pathways Analysis
1055
  (Free resource) (free) InnateDB
1056
    InnateDB
1057
  (Free resource) (free) InterMine
1058
    InterMine
1059
  (Free resource) (free) Kyoto Encyclopedia of Genes and Genomes
1060
    Kyoto Encyclopedia of Genes and Genomes
1061
  (Free resource) (free) Monarch Initiative
1062
    Monarch InitiativeMonarch Initiative
1063
  (Free resource) (free) OMA Browser: Orthologous MAtrix
1064
    OMA Browser: Orthologous MAtrixOMA Browser: Orthologous MAtrix
1065
  (Free resource) (free) OrthoDB catalog of orthologs
1066
    OrthologsOrthologs
1067
  (Free resource) (free) Pharmacogenomics Knowledge Base
1068
    Annotated Pharmacogenomic Information for STK11 [PharmGKB]Annotated Pharmacogenomic Information for STK11 [PharmGKB]
1069
  (Free resource) (free) PhosphoSitePlus
1070
    PhosphoSitePlus® - comprehensive post-translational modification resourcePhosphoSitePlus® - comprehensive post-translational modification resource
1071
  (Free resource) (free) Protein Ontology Consortium
1072
    Protein Ontology Consortium
1073
  (Free resource) (free) The Gene Wiki
1074
    The Gene Wiki
1075
  (Free resource) (free) The Weizmann Institute of Science GeneCards and MalaCards databases
1076
    GeneCard for STK11GeneCard for STK11
1077
  (Free resource) (free) Vertebrate Genome Annotation (VEGA) database
1078
    Vertebrate Genome Annotation (VEGA) database
1079
  (Free resource) (free) iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
1080
    iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
1081
1082
Research Materials
1083
  (Order form) Addgene Non-profit plasmid repository
1084
    Get Plasmids - AddgeneGet Plasmids - Addgene
1085
  ExactAntigen/Labome
1086
    reagent reviewreagent reviewreagentsreagents
1087
  (Order form) GeneCopoeia Inc.
1088
    Order miRNA target clonesOrder miRNA target clonesOrder shRNA clonesOrder shRNA clonesOrder full-length ORF cloneOrder full-length ORF clone
1089
  (Order form) GeneTex Inc
1090
    Find Recombinant Proteins and PeptidesFind Recombinant Proteins and PeptidesFind Quality AntibodiesFind Quality Antibodies
1091
  (Order form) Kazusa DNA Research Institute
1092
    Kazusa DNA Research Institute
1093
  LifeSpan BioSciences, Inc.
1094
    LSBio STK11 / LKB1 ProteinsLSBio STK11 / LKB1 Proteins
1095
  (Order form) NITE Biological Resource Center
1096
    Human cDNA clones used in NEDO Project / AK314858Human cDNA clones used in NEDO Project / AK314858Human cDNA clones used in NEDO Project / AK128518Human cDNA clones used in NEDO Project / AK128518
1097
  (Order form) Sino Biological Inc.
1098
    Human STK11 / LKB1 Gene cDNA Clone (full-length ORF Clone)Human STK11 / LKB1 Gene cDNA Clone (full-length ORF Clone)
1099
1100
Tools
1101
  (Free resource) (free) GeneMANIA
1102
    GeneMANIA