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--- a +++ b/GeneID_6794.txt @@ -0,0 +1,1102 @@ +STK11 serine/threonine kinase 11[Homo sapiens] +Gene ID: 6794, updated on 20-Apr-2023 + + +SUMMARY +------------------------------------------------------------------------------------------------- + +Official Symbol: STK11 (provided by HGNC) +Official full name: serine/threonine kinase 11 (provided by HGNC) +Primary source: HGNC:HGNC:11389 +See related: Ensembl:ENSG00000118046; MIM:602216; AllianceGenome:HGNC:11389 +Gene type: protein coding +RefSeq status: REVIEWED +Organism: Homo sapiens + +Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; +Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo + +Also known as: PJS; LKB1; hLKB1 + +Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cell +polarity and energy metabolism and functions as a tumor suppressor. Mutations in +this gene have been associated with the autosomal dominant Peutz-Jeghers +syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by +RefSeq, May 2022] + +Orthologsall (/gene/?Term=ortholog_gene_6794[group]), mouse (https://www.ncbi.nlm.nih.gov/gene/20869) + +GENOMIC CONTEXT +------------------------------------------------------------------------------------------------- + + +Location: 19p13.3 + +Annotation release Status Assembly Chromosome Location +------------------------------------------------------------------------------------------------- +RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1205778..1228431) +RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1174325..1196989) +105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1205777..1228430) +Exont count: 12 + + +BIBLIOGRAPHY +------------------------------------------------------------------------------------------------- + + +Related Articles in PubMed + +1. The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting +critical factors that mediate epithelial-mesenchymal transition. Tzavlaki K, . J +Cell Physiol, 2023 Apr, PMID 36791282. +2. LKB1 Loss Assessed by Immunohistochemistry as a Prognostic Marker to First-Line +Therapy in Advanced Non-Small-Cell Lung Cancer. Avilés-Salas A, . Curr Oncol, +2022 Dec 26, PMID 36661676., Free PMC Article(s): PMC9857995 +3. STK11 Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage +Non-Small-Cell Lung Cancer. Katipally RR, . JCO Precis Oncol, 2023 Jan, PMID +36603171. +4. A novel missense mutation of the STK11 gene in a Chinese family with +Peutz-Jeghers syndrome. Yu Z, . BMC Gastroenterol, 2022 Dec 22, PMID 36550395., Free PMC Article(s): PMC9784088 +5. Liver kinase B1 in exosomes inhibits immune checkpoint programmed death ligand 1 +and metastatic progression of intrahepatic cholangiocarcinoma. Liu Z, . Oncol +Rep, 2022 Sep, PMID 35856436., Free PMC Article(s): PMC9350976 +6. LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory +response. MacMillan S, . Commun Biol, 2022 Jun 29, PMID 35768580., Free PMC Article(s): PMC9243028 +<pre> +PHENOTYPES +------------------------------------------------------------------------------------------------- + +Review eQTL and phenotype association data in this region using PheGenI + http://www.ncbi.nlm.nih.gov/gap/PheGenI?chr=19&from=1205777&fromto=1205777+1228430&tab=0 + +Professional guidelines +------------------------------------------------------------------------------------------------- +Professional guideline + ACMG 2013 + The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in STK11 that are pathogenic or expected to be pathogenic. + + Guideline(http://www.acmg.net/docs/ACMG_Releases_Highly-Anticipated_Recommendations_on_Incidental_Findings_in_Clinical_Exome_and_Genome_Sequencing.pdf) + PubMed(/pubmed/23788249) +Associated conditions +------------------------------------------------------------------------------------------------- +Description Tests +------------------------------------------------------------------------------------------------- + +Carcinoma of pancreas + MedGen: C0235974 OMIM: 260350 GeneReviews: <span>Not available</span> +Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. + GeneReviews: <span>Not available</span> +Genome-wide association study of Alzheimer's disease with psychotic symptoms. + GeneReviews: <span>Not available</span> +Germ cell tumor of testis + MedGen: C1336708 OMIM: 273300 GeneReviews: <span>Not available</span> +Melanoma, cutaneous malignant, susceptibility to, 1 + MedGen: C1835047 OMIM: 155600 GeneReviews: <span>Not available</span> +Peutz-Jeghers syndrome + MedGen: C0031269 OMIM: 175200 GeneReviews: Peutz-Jeghers Syndrome + +Copy number response +------------------------------------------------------------------------------------------------- +Copy number response + Triplosensitivity + No evidence available (Last evaluated 2021-11-10) + + ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=STK11)Haploinsufficency + Sufficient evidence for dosage pathogenicity (Last evaluated 2021-11-10) + + ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=STK11) + PubMed(/pubmed/20623358,23892522,2563227,28231849)</pre> + +VARIATION +------------------------------------------------------------------------------------------------- + +See variants in ClinVar, http://130.14.22.58/sites/gene/clinvar/?term=STK11[gene] +See studies and variants in dbVar, http://130.14.22.58/sites/gene +See Variation Viewer (GRCh37.p13), http://130.14.22.58/sites/gene/variation/view/?q=6794[geneid]&assm=GCF_000001405.25 +See Variation Viewer (GRCh38), http://130.14.22.58/sites/gene/variation/view/?q=6794[geneid]<pre/><pre> +Genotypes + See SNP Geneview Report, http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2FSNP%2Fsnp_ref.cgi%3FlocusId%3D6794 + See 1000 Genomes Browser (GCF_000001405.25), http://130.14.22.58/sites/gene/variation/tools/1000genomes/?q=6794[geneid]&assm=GCF_000001405.25</pre> + + +INTERACTION +------------------------------------------------------------------------------------------------- + +Description of Gene Interaction table + +Product Interactant Other Gene Complex Source Pubs +------------------------------------------------------------------------------------------------- + +LKB1 phosphorylates MARK4. +NP_000446.1 NP_113605.2 MARK4 BIND PMID: 14676191 +LKB1 interacts with AMPK-alpha. +NP_000446.1 NP_006243.2 PRKAA2 BIND PMID: 14985505 +LKB1 autophosphorylates itself. +NP_000446.1 NP_000446.1 STK11 BIND PMID: 14676191 +LKB1 phosphorylates PAPK. +NP_000446.1 NP_061041.2 STRADB BIND PMID: 14676191 +Q15831 Q13315 ATM HPRD PMID: 12234250,11853558 +Q15831 Q9Y376 CAB39 HPRD PMID: 14676191 +Q15831 Q16543 CDC37 HPRD PMID: 12489981 +Q15831 Q9P0L2 MARK1 HPRD PMID: 14976552,14517247 +Q15831 Q7KZI7 MARK2 HPRD PMID: 14976552 +Q15831 Q96L34 MARK4 HPRD PMID: 14676191 +Q15831 Q9Y3A3 MOB4 HPRD PMID: 16169070 +Q15831 Q8TEW0 PARD3 HPRD PMID: 14676191 +Q15831 P54646 PRKAA2 HPRD PMID: 10642499 +Q15831 P17612 PRKACA HPRD PMID: 11853558,11297520 +Q15831 P60484 PTEN HPRD PMID: 15987703 +Q15831 P51812 RPS6KA3 HPRD PMID: 11853558,11297520 +Q15831 O75582 RPS6KA5 HPRD PMID: 11297520 +Q15831 P23443 RPS6KB1 HPRD PMID: 11853558,11297520 +Q15831 P51532 SMARCA4 HPRD PMID: 11445556 +Q15831 Q9NRH2 SNRK HPRD PMID: 15733851 +Q15831 Q15831 STK11 HPRD PMID: 11668633 +Q15831 LKB1 interacting protein 1 STK11IP HPRD PMID: 11741830 +Q15831 Protein kinase LYK5 STRADA HPRD PMID: 12805220 +Q15831 Q9C0K7 STRADB HPRD PMID: 14676191 +Q15831 TNFAIP3 interacting protein 2 TNIP2 HPRD PMID: 12595760 +Q15831 P04637 TP53 HPRD PMID: 11430832 +Affinity Capture-MS +BioGRID:112670 BioGRID:126860 A2ML1 BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:131028 ABCB5 BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:116784 ABRAXAS2 BioGRID PMID: 33961781,28514442 +Two-hybrid +BioGRID:112670 BioGRID:119283 ADIPOR1 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:120419 AGGF1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:124393 AJUBA BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:115445 AKAP9 BioGRID PMID: 33961781 +FRET; Two-hybrid +BioGRID:112670 BioGRID:106710 AKT1 BioGRID PMID: 28205554,24412244 +Affinity Capture-MS +BioGRID:112670 BioGRID:111790 ALDH18A1 BioGRID PMID: 34591612 +Two-hybrid +BioGRID:112670 BioGRID:106730 ALDOB BioGRID PMID: 24412244 +Affinity Capture-MS +BioGRID:112670 BioGRID:106775 AMY1C BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:115795 ANP32B BioGRID PMID: 24412244 +Affinity Capture-MS +BioGRID:112670 BioGRID:106798 ANXA1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:575558 ANXA8 BioGRID PMID: 33961781 +Affinity Capture-Western +BioGRID:112670 BioGRID:107587 AP2M1 BioGRID PMID: 20368287 +Reconstituted Complex +BioGRID:112670 BioGRID:106848 APP BioGRID PMID: 21832049 +FRET +BioGRID:112670 BioGRID:106864 ARAF BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:106879 ARG2 BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:128219 ARID2 BioGRID PMID: 35559673 +FRET +BioGRID:112670 BioGRID:106898 ARNT BioGRID PMID: 28205554 +Negative Genetic +BioGRID:112670 BioGRID:121948 ATG101 BioGRID PMID: 35559673 +Phenotypic Suppression +BioGRID:112670 BioGRID:115787 ATG7 BioGRID PMID: 33226137 +Negative Genetic +BioGRID:112670 BioGRID:122518 ATG9A BioGRID PMID: 35559673 +Affinity Capture-Western +BioGRID:112670 BioGRID:106962 ATM BioGRID PMID: 15713674 +FRET +BioGRID:112670 BioGRID:112666 AURKA BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:198131 Ap2m1 BioGRID PMID: 20368287 +Affinity Capture-MS +BioGRID:112670 BioGRID:118855 BABAM1 BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:113647 BAG6 BioGRID PMID: 35559673 +Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid +BioGRID:112670 BioGRID:113911 BAP1 BioGRID PMID: 32819560 +Two-hybrid +BioGRID:112670 BioGRID:120182 BCAS3 BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:115118 BCLAF1 BioGRID PMID: 35559673 +FRET +BioGRID:112670 BioGRID:114226 BECN1 BioGRID PMID: 28205554 +Negative Genetic +BioGRID:112670 BioGRID:121521 BIRC6 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:126647 BPIFA2 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:123248 BPIFB2 BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:107141 BRAF BioGRID PMID: 28205554 +Negative Genetic +BioGRID:112670 BioGRID:122599 BRCC3 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:122430 BRD9 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:123841 BRIP1 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:107160 BTK BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:126409 C5orf24 BioGRID PMID: 33961781,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:131603 C6orf58 BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:124367 C8orf76 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:107220 CA6 BioGRID PMID: 33961781 +Affinity Capture-MS; Affinity Capture-Western; Co-localization +BioGRID:112670 BioGRID:119696 CAB39 BioGRID PMID: 35271311,34591612,33961781,32707033,31554794,31217475,28514442,25852190,25241761,20562859,15561763,14676191 +Affinity Capture-MS +BioGRID:112670 BioGRID:123552 CAB39L BioGRID PMID: 33961781,28514442,26186194,20562859 +Two-hybrid +BioGRID:112670 BioGRID:107256 CALM2 BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:127632 CAMSAP1 BioGRID PMID: 35559673 +FRET +BioGRID:112670 BioGRID:117156 CBLC BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:122267 CCDC136 BioGRID PMID: 25852190 +Two-hybrid +BioGRID:112670 BioGRID:1527673 CCDC180 BioGRID PMID: 24412244 +FRET +BioGRID:112670 BioGRID:107334 CCND2 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:107338 CCNE1 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:107398 CD44 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:114125 CDC14B BioGRID PMID: 24412244 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:112670 BioGRID:116312 CDC37 BioGRID PMID: 34591612,33961781,32707033,21860411,20562859,14676191,14668798 +FRET +BioGRID:112670 BioGRID:107454 CDK4 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:107456 CDK6 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:107463 CDKN2A BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:107464 CDKN2B BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:107465 CDKN2C BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:107500 CFL2 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:114729 COPS2 BioGRID PMID: 34591612,32707033 +Affinity Capture-MS +BioGRID:112670 BioGRID:114103 COPS3 BioGRID PMID: 34591612,33961781,32707033,25852190 +Affinity Capture-MS +BioGRID:112670 BioGRID:119324 COPS4 BioGRID PMID: 34591612,32707033,25852190 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:112670 BioGRID:116183 COPS5 BioGRID PMID: 34591612,30710502 +Affinity Capture-MS +BioGRID:112670 BioGRID:116176 COPS6 BioGRID PMID: 34591612,32707033 +Affinity Capture-MS +BioGRID:112670 BioGRID:119130 COPS7A BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:122237 COPS7B BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:116124 COPS8 BioGRID PMID: 34591612,32707033 +Affinity Capture-MS +BioGRID:112670 BioGRID:119069 CRNN BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:107798 CRY2 BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:107836 CSNK1A1 BioGRID PMID: 35559673 +Synthetic Lethality +BioGRID:112670 BioGRID:107841 CSNK2A1 BioGRID PMID: 27453043 +Affinity Capture-MS +BioGRID:112670 BioGRID:107851 CST1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:107852 CST2 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:107854 CST4 BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:107888 CTSB BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:114031 CUL2 BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:114028 CUL4B BioGRID PMID: 32707033 +Affinity Capture-MS +BioGRID:112670 BioGRID:115159 CUL7 BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:107919 CYLC2 BioGRID PMID: 24412244 +Two-hybrid +BioGRID:112670 BioGRID:107958 CYP17A1 BioGRID PMID: 25640309 +Two-hybrid +BioGRID:112670 BioGRID:608722 D2HGDH BioGRID PMID: 25640309 +FRET +BioGRID:112670 BioGRID:107972 DACH1 BioGRID PMID: 28205554 +Negative Genetic +BioGRID:112670 BioGRID:121945 DHX35 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:108095 DMBT1 BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:108112 DNASE1 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:125472 DNTTIP1 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:108164 DSG3 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:108189 DVL2 BioGRID PMID: 28514442 +Two-hybrid +BioGRID:112670 BioGRID:108238 EEF1A2 BioGRID PMID: 25640309 +Affinity Capture-Western +BioGRID:112670 BioGRID:108286 EIF2B1 BioGRID PMID: 20368287 +Affinity Capture-MS +BioGRID:112670 BioGRID:114423 ENDOU BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:108288 EPHA2 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:108376 ERBB2 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:118096 ERLEC1 BioGRID PMID: 25640309 +Affinity Capture-Western; Biochemical Activity; Two-hybrid +BioGRID:112670 BioGRID:108419 ETV4 BioGRID PMID: 21150337,16912160 +Affinity Capture-MS +BioGRID:112670 BioGRID:108426 EVPL BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:229070 Eif2b1 BioGRID PMID: 20368287 +Two-hybrid +BioGRID:112670 BioGRID:116659 FAIM2 BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:123086 FAM106A BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:108472 FANCA BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:108483 FANCF BioGRID PMID: 35559673 +Two-hybrid +BioGRID:112670 BioGRID:108497 FBP1 BioGRID PMID: 24412244 +Two-hybrid +BioGRID:112670 BioGRID:114317 FBP2 BioGRID PMID: 24412244 +Affinity Capture-Western +BioGRID:112670 BioGRID:126870 FBXL14 BioGRID PMID: 29601127 +Affinity Capture-Western; Co-localization +BioGRID:112670 BioGRID:117649 FBXO22 BioGRID PMID: 31217475 +Negative Genetic +BioGRID:112670 BioGRID:127320 FBXO41 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:119962 FBXO42 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:116887 FBXW11 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:117645 FBXW8 BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:108555 FGFR4 BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:108578 FKBP4 BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:108579 FKBP5 BioGRID PMID: 34591612,33961781,32707033,28514442,25852190,20562859,14676191 +Affinity Capture-MS +BioGRID:112670 BioGRID:108601 FLG BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:122669 FYCO1 BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:119489 FZR1 BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:108887 GARS1 BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:127864 GBP6 BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:124182 GLIS2 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:115325 GNPDA1 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:109131 GPS1 BioGRID PMID: 34591612,32707033 +FRET +BioGRID:112670 BioGRID:109168 GRM1 BioGRID PMID: 28205554 +Affinity Capture-Western +BioGRID:112670 BioGRID:109187 GSK3B BioGRID PMID: 22270359 +Negative Genetic +BioGRID:112670 BioGRID:114937 GTPBP1 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:120097 GTPBP2 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:109268 H2AX BioGRID PMID: 25852190 +Affinity Capture-MS +BioGRID:112670 BioGRID:109284 HAL BioGRID PMID: 33961781 +Affinity Capture-Western; Biochemical Activity +BioGRID:112670 BioGRID:114438 HERC2 BioGRID PMID: 27259994 +FRET +BioGRID:112670 BioGRID:109330 HGF BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:109338 HIF1A BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:109345 HK1 BioGRID PMID: 34591612 +Negative Genetic +BioGRID:112670 BioGRID:109465 HOXC9 BioGRID PMID: 35559673 +Two-hybrid +BioGRID:112670 BioGRID:109501 HRAS BioGRID PMID: 24412244 +Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western +BioGRID:112670 BioGRID:109552 HSP90AA1 BioGRID PMID: 33961781,32707033,28514442,22939624,21860411,14676191,14668798 +Affinity Capture-MS +BioGRID:112670 BioGRID:109555 HSP90AA4P BioGRID PMID: 33961781,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:610599 HSP90AA5P BioGRID PMID: 33961781,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:109558 HSP90AB1 BioGRID PMID: 33961781,32707033,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:109559 HSP90AB3P BioGRID PMID: 33961781,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:576430 HSP90AB4P BioGRID PMID: 33961781,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:109535 HSPA1A BioGRID PMID: 14676191 +Affinity Capture-MS +BioGRID:112670 BioGRID:118149 HTATSF1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:120824 IARS2 BioGRID PMID: 34591612 +Two-hybrid +BioGRID:112670 BioGRID:109707 IGFBP3 BioGRID PMID: 24412244 +Affinity Capture-MS +BioGRID:112670 BioGRID:109714 IGHA1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:109715 IGHA2 BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:114089 IKBKG BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:109772 IL1RN BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:129701 INO80E BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:109916 IVD BioGRID PMID: 34591612,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:109917 IVL BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:109732 JCHAIN BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:116105 JTB BioGRID PMID: 35559673 +FRET +BioGRID:112670 BioGRID:108918 KAT2A BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:116204 KDELR2 BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:115035 KDM4A BioGRID PMID: 33961781,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:114873 KIF23 BioGRID PMID: 14676191 +Affinity Capture-MS +BioGRID:112670 BioGRID:111636 KLK10 BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:111631 KLK7 BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:110038 KPNA4 BioGRID PMID: 35559673 +Affinity Capture-Western +BioGRID:112670 BioGRID:120336 LAMTOR1 BioGRID PMID: 34821530 +FRET +BioGRID:112670 BioGRID:117727 LATS2 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:119354 LEF1 BioGRID PMID: 24412244 +Affinity Capture-MS +BioGRID:112670 BioGRID:110175 LIMS1 BioGRID PMID: 14676191 +Affinity Capture-MS +BioGRID:112670 BioGRID:110201 LOXL2 BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:110208 LPP BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:110235 LTF BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:117985 LYPD3 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:110247 LYZ BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:116348 LZTS1 BioGRID PMID: 35559673 +Synthetic Lethality; Two-hybrid +BioGRID:112670 BioGRID:111590 MAP2K1 BioGRID PMID: 27453043,24412244 +Affinity Capture-Western; FRET +BioGRID:112670 BioGRID:111592 MAP2K3 BioGRID PMID: 28628118,28205554 +FRET +BioGRID:112670 BioGRID:111593 MAP2K5 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:111594 MAP2K6 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:110381 MAP3K5 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:107819 MAPK14 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:111581 MAPK3 BioGRID PMID: 24412244 +Two-hybrid +BioGRID:112670 BioGRID:116581 MAPRE1 BioGRID PMID: 24552808 +Biochemical Activity +BioGRID:112670 BioGRID:108326 MARK2 BioGRID PMID: 16396636 +Affinity Capture-Western +BioGRID:112670 BioGRID:121760 MARK4 BioGRID PMID: 14676191 +Negative Genetic +BioGRID:112670 BioGRID:129033 MCM9 BioGRID PMID: 35559673 +Affinity Capture-Western; FRET +BioGRID:112670 BioGRID:110358 MDM2 BioGRID PMID: 35513074,28205554 +FRET +BioGRID:112670 BioGRID:110391 MET BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:119275 MLXIPL BioGRID PMID: 34461288 +Affinity Capture-MS; Co-localization +BioGRID:112670 BioGRID:122103 MMS19 BioGRID PMID: 34591612 +Two-hybrid +BioGRID:112670 BioGRID:110481 MOCS2 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:110493 MPO BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:110498 MPV17 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:125820 MTFMT BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:114560 MTMR4 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:608337 MUC5B BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:110676 MUC7 BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:110694 MYC BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:119921 NANS BioGRID PMID: 24412244 +Two-hybrid +BioGRID:112670 BioGRID:106528 NAT2 BioGRID PMID: 25640309 +Two-hybrid +BioGRID:112670 BioGRID:110632 ND2 BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:110792 NDUFB6 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:114594 NEMF BioGRID PMID: 28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:115983 NES BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:110844 NF2 BioGRID PMID: 28205554 +Negative Genetic +BioGRID:112670 BioGRID:117008 OTP BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:116413 PACSIN2 BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:111182 PDGFRA BioGRID PMID: 28205554 +Negative Genetic +BioGRID:112670 BioGRID:116848 PDS5A BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:117125 PDSS1 BioGRID PMID: 35559673 +Two-hybrid +BioGRID:112670 BioGRID:121330 PDXP BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:111788 PEX5 BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:122561 PHF23 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:111302 PIGR BioGRID PMID: 33961781 +FRET +BioGRID:112670 BioGRID:111308 PIK3CA BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:111322 PIP4K2A BioGRID PMID: 33961781,32707033,28514442 +Affinity Capture-MS +BioGRID:112670 BioGRID:113985 PIP4K2B BioGRID PMID: 32707033 +Affinity Capture-MS +BioGRID:112670 BioGRID:122928 PIP4K2C BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:114074 PKP4 BioGRID PMID: 34591612 +Two-hybrid +BioGRID:112670 BioGRID:117173 PLD3 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:126828 PLEKHA7 BioGRID PMID: 34591612 +Affinity Capture-MS +BioGRID:112670 BioGRID:123048 POF1B BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:111488 PPL BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:111508 PPP2CB BioGRID PMID: 24412244 +Negative Genetic +BioGRID:112670 BioGRID:120344 PPP2R3C BioGRID PMID: 35559673 +Affinity Capture-Western; Biochemical Activity; Two-hybrid +BioGRID:112670 BioGRID:111549 PRKAA1 BioGRID PMID: 31995728,31217475,16912160 +Co-localization +BioGRID:112670 BioGRID:111550 PRKAA2 BioGRID PMID: 25241761 +Co-localization +BioGRID:112670 BioGRID:111558 PRKAG1 BioGRID PMID: 31983282 +Negative Genetic +BioGRID:112670 BioGRID:114143 PRKRA BioGRID PMID: 35559673 +Two-hybrid +BioGRID:112670 BioGRID:118887 PRSS50 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:111638 PRTN3 BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:114872 PSMF1 BioGRID PMID: 35559673 +Affinity Capture-Western; Biochemical Activity; Co-localization; Two-hybrid +BioGRID:112670 BioGRID:111700 PTEN BioGRID PMID: 15987703 +Two-hybrid +BioGRID:112670 BioGRID:111856 RASA1 BioGRID PMID: 24412244 +FRET +BioGRID:112670 BioGRID:116356 RASSF1 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:116828 RHOBTB2 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:121946 RIC8A BioGRID PMID: 34591612 +Affinity Capture-RNA +BioGRID:112670 BioGRID:117121 RIGI BioGRID PMID: 32513696 +Affinity Capture-MS +BioGRID:112670 BioGRID:120896 RIOK2 BioGRID PMID: 33961781 +Affinity Capture-Western +BioGRID:112670 BioGRID:123598 RNF146 BioGRID PMID: 31554794 +Affinity Capture-MS +BioGRID:112670 BioGRID:122783 RPAP3 BioGRID PMID: 14676191 +Negative Genetic +BioGRID:112670 BioGRID:121820 RPRD1B BioGRID PMID: 35559673 +Co-localization +BioGRID:112670 BioGRID:112112 RPS6KB1 BioGRID PMID: 25241761 +Two-hybrid +BioGRID:112670 BioGRID:121504 S100A14 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:112188 S100A9 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:114324 SCEL BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:112291 SDHB BioGRID PMID: 35559673 +Two-hybrid +BioGRID:112670 BioGRID:116015 SEPTIN9 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:108307 SERPINB1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:111293 SERPINB13 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:112223 SERPINB3 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:112224 SERPINB4 BioGRID PMID: 33961781 +Affinity Capture-MS; Two-hybrid +BioGRID:112670 BioGRID:111286 SERPINB5 BioGRID PMID: 33961781,25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:118845 SETD2 BioGRID PMID: 33961781 +Biochemical Activity +BioGRID:112670 BioGRID:127260 SIK1 BioGRID PMID: 16396636 +Affinity Capture-Western; Biochemical Activity +BioGRID:112670 BioGRID:116983 SIRT1 BioGRID PMID: 27259994,18687677 +Negative Genetic +BioGRID:112670 BioGRID:124002 SLC25A33 BioGRID PMID: 35559673 +Negative Genetic +BioGRID:112670 BioGRID:115726 SLC30A9 BioGRID PMID: 35559673 +FRET +BioGRID:112670 BioGRID:110261 SMAD1 BioGRID PMID: 28205554 +Affinity Capture-MS; Affinity Capture-Western; FRET; Reconstituted Complex +BioGRID:112670 BioGRID:112481 SMARCA4 BioGRID PMID: 28205554,14676191,11445556 +Affinity Capture-MS +BioGRID:112670 BioGRID:112483 SMARCC1 BioGRID PMID: 14676191 +Affinity Capture-Western +BioGRID:112670 BioGRID:112499 SNAI1 BioGRID PMID: 29601127 +Biochemical Activity +BioGRID:112670 BioGRID:120211 SNRK BioGRID PMID: 15733851 +Affinity Capture-MS +BioGRID:112670 BioGRID:119535 SNX9 BioGRID PMID: 33961781 +Negative Genetic +BioGRID:112670 BioGRID:119936 SOX18 BioGRID PMID: 35559673 +FRET +BioGRID:112670 BioGRID:112542 SOX4 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:117335 SPDEF BioGRID PMID: 16912160 +Affinity Capture-MS +BioGRID:112670 BioGRID:112585 SPRR3 BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:112645 ST14 BioGRID PMID: 25640309 +FRET +BioGRID:112670 BioGRID:112670 STK11 BioGRID PMID: 28205554 +Affinity Capture-Western +BioGRID:112670 BioGRID:125352 STK11IP BioGRID PMID: 11741830 +Two-hybrid +BioGRID:112670 BioGRID:114011 STK24 BioGRID PMID: 25640309 +Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid +BioGRID:112670 BioGRID:124934 STRADA BioGRID PMID: 35271311,34591612,33961781,32707033,31554794,28514442,25852190,25241761,21860411,20562859,15561763,14676191,12805220 +Affinity Capture-MS; Biochemical Activity +BioGRID:112670 BioGRID:120668 STRADB BioGRID PMID: 35271311,34591612,33961781,32707033,28514442,20562859,14676191 +Affinity Capture-Western +BioGRID:112670 BioGRID:115563 STUB1 BioGRID PMID: 21860411 +Two-hybrid +BioGRID:112670 BioGRID:120346 STX17 BioGRID PMID: 24412244 +Affinity Capture-MS +BioGRID:112670 BioGRID:112689 SULT2B1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:112697 SUPT5H BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:112698 SUPT6H BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:120889 TBC1D23 BioGRID PMID: 21516116 +Two-hybrid +BioGRID:112670 BioGRID:116994 TDRD7 BioGRID PMID: 24412244 +FRET +BioGRID:112670 BioGRID:114041 TEAD2 BioGRID PMID: 28205554 +FRET +BioGRID:112670 BioGRID:112874 TERT BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:112909 TGM1 BioGRID PMID: 33961781 +Affinity Capture-MS +BioGRID:112670 BioGRID:112911 TGM3 BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:112921 THOP1 BioGRID PMID: 25640309 +Two-hybrid +BioGRID:112670 BioGRID:112925 THRSP BioGRID PMID: 25640309 +FRET +BioGRID:112670 BioGRID:112986 TNFRSF1A BioGRID PMID: 28205554 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid +BioGRID:112670 BioGRID:122573 TNIP2 BioGRID PMID: 27609421,12753905,12595760 +Affinity Capture-Western +BioGRID:112670 BioGRID:114207 TNKS BioGRID PMID: 31554794 +Affinity Capture-Western +BioGRID:112670 BioGRID:123257 TNKS2 BioGRID PMID: 31554794 +Affinity Capture-MS; Affinity Capture-Western; FRET +BioGRID:112670 BioGRID:113010 TP53 BioGRID PMID: 33961781,28205554,11430832 +Affinity Capture-Western +BioGRID:112670 BioGRID:114181 TP63 BioGRID PMID: 21150337 +Two-hybrid +BioGRID:112670 BioGRID:113500 TRIM25 BioGRID PMID: 25640309 +Two-hybrid +BioGRID:112670 BioGRID:119593 TRMO BioGRID PMID: 24412244 +Negative Genetic +BioGRID:112670 BioGRID:113100 TSC2 BioGRID PMID: 35559673 +Two-hybrid +BioGRID:112670 BioGRID:113102 TSG101 BioGRID PMID: 25640309 +Two-hybrid +BioGRID:112670 BioGRID:113603 TUBA1A BioGRID PMID: 25640309 +Two-hybrid +BioGRID:112670 BioGRID:115655 TUBB4A BioGRID PMID: 25640309 +Negative Genetic +BioGRID:112670 BioGRID:113149 TYMS BioGRID PMID: 35559673 +Biochemical Activity +BioGRID:112670 BioGRID:113170 UBE2D2 BioGRID PMID: 21860411 +Affinity Capture-Western +BioGRID:112670 BioGRID:121973 UBE2O BioGRID PMID: 31900314 +Negative Genetic +BioGRID:112670 BioGRID:118858 UBE2T BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:112670 BioGRID:113866 USP11 BioGRID PMID: 14676191 +Two-hybrid +BioGRID:112670 BioGRID:112804 VPS72 BioGRID PMID: 25640309 +Affinity Capture-MS +BioGRID:112670 BioGRID:121649 WDR48 BioGRID PMID: 19615732 +Affinity Capture-Western +BioGRID:112670 BioGRID:116350 WDR6 BioGRID PMID: 17216128 +FRET +BioGRID:112670 BioGRID:113327 WT1 BioGRID PMID: 28205554 +Two-hybrid +BioGRID:112670 BioGRID:113344 XPA BioGRID PMID: 24412244 +Negative Genetic +BioGRID:112670 BioGRID:119655 YPEL5 BioGRID PMID: 35559673 +FRET +BioGRID:112670 BioGRID:113364 YWHAG BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:112670 BioGRID:125855 ZG16B BioGRID PMID: 33961781 +Two-hybrid +BioGRID:112670 BioGRID:113528 ZNF189 BioGRID PMID: 24412244 +Two-hybrid +BioGRID:112670 BioGRID:116536 ZNF510 BioGRID PMID: 24412244 + +GENERAL GENE INFO +------------------------------------------------------------------------------------------------- + +Marker + REU1905 (e-PCR) Links:UniSTS:257089 + RH104368 (e-PCR) Links:UniSTS:98693 + Stk11 (e-PCR), detects polymorphism Links:UniSTS:546518 + + +Homology + Homologs of the STK11 gene + The STK11 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and frog. + Orthologs from Annotation Pipeline (/gene/?Term=ortholog_gene_6794[group]): + Orthologs + +Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA) + +Function GO ID Evidence +------------------------------------------------------------------------------------------------- +enables ATP binding GO:0000000 PMID: 12805220 +enables LRR domain binding GO:0000000 - +enables magnesium ion binding GO:0000000 PMID: 12805220 +enables p53 binding GO:0000000 PMID: 11430832 +enables protein binding GO:0000000 PMID: 12595760,12753905,12805220,14676191,17216128,19274086,19513107,19892943,20562859,22575644,22939624,24362629,25036637,25241761,25329316,25852190,26479318,28514442,32707033,34591612 +enables protein kinase activator activit... GO:0000000 PMID: 19892943 +enables protein serine kinase activity GO:0000000 - +enables protein serine/threonine kinase ... GO:0000000 PMID: 21873635 +enables protein serine/threonine kinase ... GO:0000000 PMID: 11430832,12805220,19892943 +enables protein serine/threonine kinase ... GO:0000000 - +enables protein-containing complex bindi... GO:0000000 - + +Processs GO ID Evidence +------------------------------------------------------------------------------------------------- +involved_in DNA damage response GO:0000000 PMID: 21873635 +involved_in DNA damage response GO:0000000 PMID: 25329316 +acts_upstream_of_negative_effect G1 to G... GO:0000000 PMID: 17216128 +acts_upstream_of_negative_effect G1 to G... GO:0000000 PMID: 12805220 +involved_in Golgi localization GO:0000000 - +involved_in T cell receptor signaling pa... GO:0000000 - +involved_in activation of protein kinase... GO:0000000 PMID: 19892943 +involved_in activation of protein kinase... GO:0000000 PMID: 15731909 +involved_in activation of protein kinase... GO:0000000 - +involved_in anoikis GO:0000000 PMID: 19622832 +involved_in autophagy GO:0000000 - +involved_in axonogenesis GO:0000000 - +involved_in cellular response to UV-B GO:0000000 PMID: 25329316 +involved_in dendrite extension GO:0000000 - +involved_in epithelial cell proliferatio... GO:0000000 - +involved_in establishment of cell polari... GO:0000000 PMID: 21873635 +involved_in establishment of cell polari... GO:0000000 PMID: 24643070 +involved_in establishment of cell polari... GO:0000000 - +involved_in glucose homeostasis GO:0000000 - +involved_in intrinsic apoptotic signalin... GO:0000000 PMID: 11430832 +involved_in negative regulation of TORC1... GO:0000000 PMID: 23878245 +involved_in negative regulation of canon... GO:0000000 PMID: 15731909 +involved_in negative regulation of cell ... GO:0000000 - +involved_in negative regulation of cell ... GO:0000000 PMID: 17216128,25329316 +involved_in negative regulation of cold-... GO:0000000 PMID: 27461402 +involved_in negative regulation of epith... GO:0000000 - +involved_in peptidyl-threonine phosphory... GO:0000000 PMID: 12805220 +involved_in positive regulation of autop... GO:0000000 PMID: 23878245 +involved_in positive regulation of axono... GO:0000000 - +involved_in positive regulation of gluco... GO:0000000 - +involved_in positive regulation of prote... GO:0000000 - +involved_in positive regulation of trans... GO:0000000 PMID: 18311138 +involved_in positive regulation of vesic... GO:0000000 PMID: 21873635 +involved_in positive regulation of vesic... GO:0000000 PMID: 24643070 +involved_in positive thymic T cell selec... GO:0000000 - +involved_in protein autophosphorylation GO:0000000 PMID: 11430832 +involved_in protein dephosphorylation GO:0000000 PMID: 15731909 +involved_in protein localization to nucl... GO:0000000 - +involved_in protein phosphorylation GO:0000000 PMID: 21873635 +involved_in protein phosphorylation GO:0000000 PMID: 12805220,25329316 +involved_in regulation of Wnt signaling ... GO:0000000 PMID: 21873635 +involved_in regulation of cell cycle GO:0000000 - +involved_in regulation of cell growth GO:0000000 - +involved_in regulation of dendrite morph... GO:0000000 - +involved_in regulation of protein kinase... GO:0000000 - +involved_in regulation of signal transdu... GO:0000000 - +involved_in response to activity GO:0000000 - +involved_in response to glucagon GO:0000000 - +involved_in response to ionizing radiati... GO:0000000 - +involved_in response to lipid GO:0000000 - +involved_in response to thyroid hormone GO:0000000 - +involved_in signal transduction GO:0000000 PMID: 21873635 +involved_in spermatogenesis GO:0000000 - +involved_in tissue homeostasis GO:0000000 - +involved_in vasculature development GO:0000000 - + +Component GO ID Evidence +------------------------------------------------------------------------------------------------- +located_in Z disc GO:0000000 - +is_active_in cytoplasm GO:0000000 PMID: 21873635 +located_in cytoplasm GO:0000000 PMID: 11430832,12805220,14517248,17216128,18854309 +located_in cytoplasm GO:0000000 - +located_in cytosol GO:0000000 - +located_in cytosol GO:0000000 - +located_in cytosol GO:0000000 - +located_in extracellular exosome GO:0000000 PMID: 19056867 +part_of intracellular protein-containing... GO:0000000 PMID: 12805220 +located_in membrane GO:0000000 - +located_in mitochondrion GO:0000000 PMID: 11430832 +located_in nucleoplasm GO:0000000 - +located_in nucleoplasm GO:0000000 - +is_active_in nucleus GO:0000000 PMID: 21873635 +located_in nucleus GO:0000000 PMID: 12805220,18854309 +part_of serine/threonine protein kinase ... GO:0000000 PMID: 19892943 +part_of serine/threonine protein kinase ... GO:0000000 - + +GENERAL PROTEIN INFORMATION +------------------------------------------------------------------------------------------------- +Preferred Names + serine/threonine-protein kinase STK11 +Names + liver kinase B1 + polarization-related protein LKB1 + renal carcinoma antigen NY-REN-19 + serine/threonine-protein kinase 11 + serine/threonine-protein kinase LKB1 +NP_000446.1 + EC 2.7.11.1 +NP_001394184.1 + EC 2.7.11.1 + +NCBI REFERENCE SEQUENCES (RefSeq) +------------------------------------------------------------------------------------------------- + +RefSeqs maintained independently of Annotated Genomes + +These reference sequences exist independently of genome builds. +These reference sequences are curated independently of the genome annotation cycle, +so their versions may not match the RefSeq versions in the current genome build. +Identify version mismatches by comparing the version of the RefSeq in this section to +the one reported in Genomic regions, transcripts, and products section above. + + Genomic + NG_007460.2 RefSeqGene + Range 21392..44028 + Download GenBank FASTA Sequence Viewer (Graphics) + + + + mRNA and Protein(s) + + NM_000455.5 → NP_000446.1 REVIEWEDserine/threonine-protein kinase STK11 isoform 1 + + See proteins identical to NP_000446.1 at http://130.14.22.58/ipg/NP_000446.1/ + + Source sequence(s): AC011544, BC007981, BC019334, BM993274, BQ222023, BU174122, BU739451 + Consensus CDS: CCDS45896.1 + UniProtKB/TrEMBL: A0A0S2Z4D1 + UniProtKB/Swiss-Prot: E7EW76 + UniProtKB/Swiss-Prot: Q15831 + + Related Ensembl: ENSP00000324856.6, ENST00000326873.12 + Conserved Domains (1)summary + cd14119: + Location:55 - 309 + STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1 + + NM_001407255.1 → NP_001394184.1 REVIEWEDserine/threonine-protein kinase STK11 isoform 2 + Source sequence(s): AC011544 + + RNA + + NR_176325.1 RNA Sequence + Source sequence(s): AC004221, AC011544 + +RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03 +The following sections contain reference sequences that belong to a specific genome build. +This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which +this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both +reference and alternate assemblies. Model RNAs and proteins are also reported here. + +Reference GRCh38.p14 Primary Assembly + + Genomic + NC_000019.10 Reference GRCh38.p14 Primary Assembly + Range 1205777..1228430 + Download GenBank FASTA Sequence Viewer (Graphics) + +Alternate T2T-CHM13v2.0 + + Genomic + NC_060943.1 Alternate T2T-CHM13v2.0 + Range 1174324..1196988 + Download GenBank FASTA Sequence Viewer (Graphics) + + + +RELATED SEQUENCES +------------------------------------------------------------------------------------------------- + +Nucleotide Protein +------------------------------------------------------------------------------------------------- +genomic AC004221.2 AAF97257.1 +genomic AC011544.6(26171..45903) None +genomic AH005839.2 AAB97833.1 +genomic AH006100.2 AAC15742.1 +genomic CH471139.2 EAW69538.1 + EAW69539 + EAW69540 +genomic CP068259.2(1174325..1196989) None +mRNA AB209553.1 BAD92790.1 +mRNA AF035625.1 AAC39527.1 +mRNA AF217978.1 AAG17221.1 +mRNA AJ844634.2 CAH59749.2 +mRNA AK128518.1 None +mRNA AK314858.1 BAG37374.1 +mRNA BC007981.2 AAH07981.1 +mRNA BC019334.1 AAH19334.1 +mRNA BM993274.1 None +mRNA BQ222023.1 None +mRNA BU174122.1 None +mRNA BU739451.1 None +mRNA EF644172.1 ABR45718.1 +mRNA GU573916.1 ADD71158.1 +mRNA KU178339.1 ALQ33797.1 +mRNA KU178340.1 ALQ33798.1 +mRNA U63333.1 AAB05809.1 + +Protein Accession Links +------------------------------------------------------------------------------------------------- +Q15831.1 GenPept(/protein/3024670) UniProtKB/Swiss-Prot:Q15831 + +GENE LINKOUT +------------------------------------------------------------------------------------------------- +The following LinkOut(www.ncbi.nlm.nih.gov/projects/linkout/index.html) resources +are supplied by external providers. These providers are responsible for +maintaining the links. + +Chemical Information + (Free resource) (free) Interologous Interaction Database + Interologous Interaction Database + (Order form) MilliporeSigma + Stk11 productsStk11 products + (Order form) Novus Biologicals + Peptides and ProteinsPeptides and ProteinsLysatesLysatesPrimary AntibodiesPrimary Antibodies + +Medical + (Free resource) (free) MedlinePlus Health Information + STK11 geneSTK11 gene + +Molecular Biology Databases + (Free resource) (free) Bgee database + STK11 gene expressionSTK11 gene expression + (Free resource) (free) BioGPS + BioGPS + (Free resource) (free) BioGRID Open Repository of CRISPR Screens (ORCS) + BioGRID CRISPR Screen Phenotypes (153 hits/1229 screens)BioGRID CRISPR Screen Phenotypes (153 hits/1229 screens) + (Free resource) (free) CREB Target Gene Database + CREB Target Gene Database + (Free resource) (Free registration required) (free) Creative Biogene + serine/threonine kinase 11serine/threonine kinase 11 + (Free resource) (free) Eukaryotic Promoter Database + STK11_1STK11_1 + (Free resource) (free) GenAge Database of Aging Related Genes + GenAge Database of Aging Related Genes + (Order form) GenScript latest version of gene cDNA ORF Clone + GenScript latest version of gene cDNA ORF Clone + (Free resource) (free) GeneNetwork + Records for gene expression in HumanRecords for gene expression in Human + (Free resource) (free) Genevisible + STK11STK11 + (Free resource) (free) GlyGen glycoinformatics resource + GlyGen glycoinformatics resource + (Free resource) (free) Guide to Pharmacology + serine/threonine kinase 11 geneserine/threonine kinase 11 gene + (Free resource) (Free registration required) (free) Human Gene Mutation Database + Human Gene Mutation Database + (Free resource) (free) Human eFP Browser + Human eFP BrowserHuman eFP BrowserHuman eFP Browser + Ingenuity Pathways Analysis + Ingenuity Pathways Analysis + (Free resource) (free) InnateDB + InnateDB + (Free resource) (free) InterMine + InterMine + (Free resource) (free) Kyoto Encyclopedia of Genes and Genomes + Kyoto Encyclopedia of Genes and Genomes + (Free resource) (free) Monarch Initiative + Monarch InitiativeMonarch Initiative + (Free resource) (free) OMA Browser: Orthologous MAtrix + OMA Browser: Orthologous MAtrixOMA Browser: Orthologous MAtrix + (Free resource) (free) OrthoDB catalog of orthologs + OrthologsOrthologs + (Free resource) (free) Pharmacogenomics Knowledge Base + Annotated Pharmacogenomic Information for STK11 [PharmGKB]Annotated Pharmacogenomic Information for STK11 [PharmGKB] + (Free resource) (free) PhosphoSitePlus + PhosphoSitePlus® - comprehensive post-translational modification resourcePhosphoSitePlus® - comprehensive post-translational modification resource + (Free resource) (free) Protein Ontology Consortium + Protein Ontology Consortium + (Free resource) (free) The Gene Wiki + The Gene Wiki + (Free resource) (free) The Weizmann Institute of Science GeneCards and MalaCards databases + GeneCard for STK11GeneCard for STK11 + (Free resource) (free) Vertebrate Genome Annotation (VEGA) database + Vertebrate Genome Annotation (VEGA) database + (Free resource) (free) iRefWeb - iRefIndex release 9.0 - Consolidated Interactome + iRefWeb - iRefIndex release 9.0 - Consolidated Interactome + +Research Materials + (Order form) Addgene Non-profit plasmid repository + Get Plasmids - AddgeneGet Plasmids - Addgene + ExactAntigen/Labome + reagent reviewreagent reviewreagentsreagents + (Order form) GeneCopoeia Inc. + Order miRNA target clonesOrder miRNA target clonesOrder shRNA clonesOrder shRNA clonesOrder full-length ORF cloneOrder full-length ORF clone + (Order form) GeneTex Inc + Find Recombinant Proteins and PeptidesFind Recombinant Proteins and PeptidesFind Quality AntibodiesFind Quality Antibodies + (Order form) Kazusa DNA Research Institute + Kazusa DNA Research Institute + LifeSpan BioSciences, Inc. + LSBio STK11 / LKB1 ProteinsLSBio STK11 / LKB1 Proteins + (Order form) NITE Biological Resource Center + Human cDNA clones used in NEDO Project / AK314858Human cDNA clones used in NEDO Project / AK314858Human cDNA clones used in NEDO Project / AK128518Human cDNA clones used in NEDO Project / AK128518 + (Order form) Sino Biological Inc. + Human STK11 / LKB1 Gene cDNA Clone (full-length ORF Clone)Human STK11 / LKB1 Gene cDNA Clone (full-length ORF Clone) + +Tools + (Free resource) (free) GeneMANIA + GeneMANIA \ No newline at end of file