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| 1 | BRCA2 BRCA2 DNA repair associated[Homo sapiens] |
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| 2 | Gene ID: 675, updated on 1-May-2023 |
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| 3 | |||
| 4 | |||
| 5 | SUMMARY |
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| 6 | ------------------------------------------------------------------------------------------------- |
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| 7 | |||
| 8 | Official Symbol: BRCA2 (provided by HGNC) |
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| 9 | Official full name: BRCA2 DNA repair associated (provided by HGNC) |
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| 10 | Primary source: HGNC:HGNC:1101 |
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| 11 | See related: Ensembl:ENSG00000139618; MIM:600185; AllianceGenome:HGNC:1101 |
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| 12 | Gene type: protein coding |
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| 13 | RefSeq status: REVIEWED |
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| 14 | Organism: Homo sapiens |
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| 15 | |||
| 16 | Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; |
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| 17 | Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
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| 18 | |||
| 19 | Also known as: FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2 |
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| 20 | |||
| 21 | Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk |
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| 22 | of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in |
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| 23 | maintenance of genome stability, specifically the homologous recombination |
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| 24 | pathway for double-strand DNA repair. The largest exon in both genes is exon 11, |
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| 25 | which harbors the most important and frequent mutations in breast cancer |
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| 26 | patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 |
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| 27 | protein contains several copies of a 70 aa motif called the BRC motif, and these |
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| 28 | motifs mediate binding to the RAD51 recombinase which functions in DNA repair. |
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| 29 | BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations |
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| 30 | generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided |
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| 31 | by RefSeq, May 2020] |
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| 32 | |||
| 33 | Orthologsall (/gene/?Term=ortholog_gene_675[group]), mouse (https://www.ncbi.nlm.nih.gov/gene/12190) |
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| 34 | |||
| 35 | GENOMIC CONTEXT |
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| 36 | ------------------------------------------------------------------------------------------------- |
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| 37 | |||
| 38 | |||
| 39 | Location: 13q13.1 |
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| 40 | |||
| 41 | Annotation release Status Assembly Chromosome Location |
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| 42 | ------------------------------------------------------------------------------------------------- |
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| 43 | RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (32315508..32400268) |
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| 44 | RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (31532753..31617510) |
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| 45 | 105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (32889645..32974405) |
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| 46 | Exont count: 28 |
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| 47 | |||
| 48 | |||
| 49 | BIBLIOGRAPHY |
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| 50 | ------------------------------------------------------------------------------------------------- |
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| 51 | |||
| 52 | |||
| 53 | Related Articles in PubMed |
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| 54 | |||
| 55 | 1. BRCA2 gene mutation in cancer. Xie C, . Medicine (Baltimore), 2022 Nov 11, PMID |
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| 56 | 36397405., Free PMC Article(s): PMC9666215 |
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| 57 | 2. Characteristics of BRCA2 Mutated Prostate Cancer at Presentation. Han H, . Int J |
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| 58 | Mol Sci, 2022 Nov 3, PMID 36362213., Free PMC Article(s): PMC9659116 |
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| 59 | 3. Emergence of BRCA Reversion Mutations in Patients with Metastatic |
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| 60 | Castration-resistant Prostate Cancer After Treatment with Rucaparib. Loehr A, . |
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| 61 | Eur Urol, 2023 Mar, PMID 36243543. |
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| 62 | 4. Analysis of BRCA2 Copy Number Loss and Genomic Instability in Circulating Tumor |
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| 63 | Cells from Patients with Metastatic Castration-resistant Prostate Cancer. Barnett |
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| 64 | ES, . Eur Urol, 2023 Feb, PMID 36123219. |
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| 65 | 5. Do Female BRCA2 Pathogenic Variant Carriers Have an Increased Risk of Lung |
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| 66 | Cancer? Fallet V, . J Clin Oncol, 2022 Aug 1, PMID 35549390. |
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| 67 | 6. Divergent binding mode for a protozoan BRC repeat to RAD51. Pantelejevs T, . |
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| 68 | Biochem J, 2022 May 27, PMID 35502837., Free PMC Article(s): PMC9162458 |
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| 69 | <pre> |
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| 70 | PHENOTYPES |
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| 71 | ------------------------------------------------------------------------------------------------- |
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| 72 | |||
| 73 | Review eQTL and phenotype association data in this region using PheGenI |
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| 74 | http://www.ncbi.nlm.nih.gov/gap/PheGenI?chr=13&from=32315507&fromto=32315507+32400267&tab=0 |
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| 75 | |||
| 76 | Professional guidelines |
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| 77 | ------------------------------------------------------------------------------------------------- |
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| 78 | Professional guideline |
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| 79 | ACMG 2013 |
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| 80 | The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in BRCA2 that are pathogenic or expected to be pathogenic. |
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| 81 | |||
| 82 | Guideline(http://www.acmg.net/docs/ACMG_Releases_Highly-Anticipated_Recommendations_on_Incidental_Findings_in_Clinical_Exome_and_Genome_Sequencing.pdf) |
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| 83 | PubMed(/pubmed/23788249) |
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| 84 | Associated conditions |
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| 85 | ------------------------------------------------------------------------------------------------- |
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| 86 | Description Tests |
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| 87 | ------------------------------------------------------------------------------------------------- |
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| 88 | |||
| 89 | Breast-ovarian cancer, familial, susceptibility to, 2 |
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| 90 | MedGen: C2675520 OMIM: 612555 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer |
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| 91 | Discovery and refinement of loci associated with lipid levels. |
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| 92 | GeneReviews: <span>Not available</span> |
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| 93 | Familial cancer of breast |
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| 94 | MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer |
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| 95 | Fanconi anemia complementation group D1 |
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| 96 | MedGen: C1838457 OMIM: 605724 GeneReviews: Wilms Tumor Predisposition, Fanconi Anemia, Esophageal Atresia/Tracheoesophageal Fistula Overview |
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| 97 | Genome-wide association studies identify four ER negative-specific breast cancer risk loci. |
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| 98 | GeneReviews: <span>Not available</span> |
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| 99 | Glioma susceptibility 3 |
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| 100 | MedGen: C2751641 OMIM: 613029 GeneReviews: <span>Not available</span> |
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| 101 | Hereditary breast ovarian cancer syndrome |
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| 102 | MedGen: C0677776 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer |
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| 103 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. |
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| 104 | GeneReviews: <span>Not available</span> |
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| 105 | Malignant tumor of prostate |
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| 106 | MedGen: C0376358 OMIM: 176807 GeneReviews: <span>Not available</span> |
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| 107 | Medulloblastoma |
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| 108 | MedGen: C0025149 OMIM: 155255 GeneReviews: <span>Not available</span> |
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| 109 | Pancreatic cancer, susceptibility to, 2 |
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| 110 | MedGen: C3150546 OMIM: 613347 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer |
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| 111 | Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. |
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| 112 | GeneReviews: <span>Not available</span> |
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| 113 | Wilms tumor 1 |
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| 114 | MedGen: CN033288 OMIM: 194070 GeneReviews: Wilms Tumor Predisposition, PAX6-Related Aniridia, WT1 Disorder |
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| 115 | |||
| 116 | Copy number response |
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| 117 | ------------------------------------------------------------------------------------------------- |
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| 118 | Copy number response |
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| 119 | Haploinsufficency |
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| 120 | Sufficient evidence for dosage pathogenicity (Last evaluated 2021-07-14) |
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| 121 | |||
| 122 | ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=BRCA2) |
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| 123 | PubMed(/pubmed/11897832,12097290,12569143,16199546,17063271,25632310)Triplosensitivity |
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| 124 | No evidence available (Last evaluated 2021-07-14) |
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| 125 | |||
| 126 | ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=BRCA2)</pre> |
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| 127 | |||
| 128 | VARIATION |
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| 129 | ------------------------------------------------------------------------------------------------- |
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| 130 | |||
| 131 | See variants in ClinVar, http://130.14.22.153/sites/gene/clinvar/?term=BRCA2[gene] |
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| 132 | See studies and variants in dbVar, http://130.14.22.153/sites/gene |
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| 133 | See Variation Viewer (GRCh37.p13), http://130.14.22.153/sites/gene/variation/view/?q=675[geneid]&assm=GCF_000001405.25 |
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| 134 | See Variation Viewer (GRCh38), http://130.14.22.153/sites/gene/variation/view/?q=675[geneid]<pre/><pre> |
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| 135 | Genotypes |
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| 136 | See SNP Geneview Report, http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2FSNP%2Fsnp_ref.cgi%3FlocusId%3D675 |
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| 137 | See 1000 Genomes Browser (GCF_000001405.25), http://130.14.22.153/sites/gene/variation/tools/1000genomes/?q=675[geneid]&assm=GCF_000001405.25</pre> |
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| 138 | |||
| 139 | |||
| 140 | INTERACTION |
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| 141 | ------------------------------------------------------------------------------------------------- |
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| 142 | |||
| 143 | Description of Gene Interaction table |
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| 144 | |||
| 145 | Product Interactant Other Gene Complex Source Pubs |
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| 146 | ------------------------------------------------------------------------------------------------- |
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| 147 | |||
| 148 | BRCA1 interacts with BRCA2. |
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| 149 | NP_000050.1 NP_009227.1 BRCA1 BIND PMID: 9774970 |
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| 150 | FANCD2 interacts with BRCA2. |
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| 151 | NP_000050.1 NP_149075.2 FANCD2 BIND PMID: 15115758 |
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| 152 | FANCG interacts with BRCA2. |
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| 153 | NP_000050.1 NP_004620.1 FANCG BIND PMID: 12915460 |
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| 154 | BRCA2 interacts with hsFLNa. |
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| 155 | NP_000050.1 NP_001447.1 FLNA BIND PMID: 11602572 |
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| 156 | BRCA2 interacts with RAD51. |
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| 157 | NP_000050.1 NP_002866.2 RAD51 BIND PMID: 9774970 |
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| 158 | BRCA2 interacts with Rad51. |
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| 159 | NP_000050.1 NP_597994.1 RAD51 BIND PMID: 9774970 |
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| 160 | BRCA2 interacts with an unspecified isoform of RAD51. |
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| 161 | NP_000050.1 RAD51 BIND PMID: 15800615 |
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| 162 | SMAD3 interacts with BRCA2. |
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| 163 | NP_000050.1 NP_005893.1 SMAD3 BIND PMID: 12165866 |
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| 164 | CDK2/CCNA2 (CDK2-cyclinA) phosphorylates BRCA2. This interaction was modeled on a demonstrated interaction between CDK2/CCNA2 from an unspecified species and human BRCA2. |
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| 165 | NP_000050.1 BIND PMID: 15800615 |
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| 166 | P51587 Q9P287 BCCIP HPRD PMID: 11313963 |
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| 167 | P51587 P38398 BRCA1 HPRD PMID: 11477095,9774970 |
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| 168 | P51587 O60566 BUB1B HPRD PMID: 10749118 |
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| 169 | P51587 P20248 CCNA2 HPRD PMID: 15800651 |
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| 170 | P51587 P24864 CCNE1 HPRD PMID: 15800651 |
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| 171 | P51587 P06493 CDK1 HPRD PMID: 15800651 |
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| 172 | P51587 P24941 CDK2 HPRD PMID: 15800651,15800615 |
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| 173 | P51587 Q8N1V2 CFAP52 HPRD PMID: 15967112 |
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| 174 | P51587 Q7Z589 EMSY HPRD PMID: 14651845 |
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| 175 | P51587 Q9BXW9 FANCD2 HPRD PMID: 15115758 |
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| 176 | P51587 Q9HB96 FANCE HPRD PMID: 15199141 |
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| 177 | P51587 O15287 FANCG HPRD PMID: 16621732,12915460 |
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| 178 | P51587 P21333 FLNA HPRD PMID: 11602572 |
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| 179 | P51587 Q9P0W2 HMG20B HPRD PMID: 11207365 |
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| 180 | P51587 Q92831 KAT2B HPRD PMID: 9824164 |
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| 181 | P51587 Q86YC2 PALB2 HPRD PMID: 16793542 |
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| 182 | P51587 P53350 PLK1 HPRD PMID: 12815053 |
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| 183 | P51587 Q06609 RAD51 HPRD PMID: 15800651,15800615,15065660,12619154,11477095,10551859,9560268,9523196,9405383,9126738 |
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| 184 | P51587 P27694 RPA1 HPRD PMID: 12527904 |
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| 185 | P51587 P60896 SEM1 HPRD PMID: 12228710,10373512 |
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| 186 | P51587 P84022 SMAD3 HPRD PMID: 12165866 |
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| 187 | P51587 P42229 STAT5A HPRD PMID: 12459499 |
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| 188 | P51587 P04637 TP53 HPRD PMID: 9811893 |
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| 189 | Affinity Capture-MS |
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| 190 | BioGRID:107142 BioGRID:123290 AARSD1 BioGRID PMID: 33961781,28514442 |
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| 191 | Affinity Capture-MS |
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| 192 | BioGRID:107142 BioGRID:106683 AGA BioGRID PMID: 27433848 |
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| 193 | Proximity Label-MS |
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| 194 | BioGRID:107142 BioGRID:118937 ANAPC2 BioGRID PMID: 34079125 |
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| 195 | Negative Genetic; Proximity Label-MS |
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| 196 | BioGRID:107142 BioGRID:106825 APEX1 BioGRID PMID: 34079125,28319085 |
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| 197 | Affinity Capture-MS |
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| 198 | BioGRID:107142 BioGRID:137464 AQP7P3 BioGRID PMID: 27433848 |
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| 199 | Proximity Label-MS |
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| 200 | BioGRID:107142 BioGRID:117368 ASF1A BioGRID PMID: 34079125 |
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| 201 | Proximity Label-MS |
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| 202 | BioGRID:107142 BioGRID:114528 ASH2L BioGRID PMID: 34079125 |
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| 203 | Affinity Capture-MS |
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| 204 | BioGRID:107142 BioGRID:128104 ASXL1 BioGRID PMID: 32683582 |
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| 205 | Reconstituted Complex |
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| 206 | BioGRID:107142 BioGRID:106962 ATM BioGRID PMID: 15199141 |
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| 207 | Protein-peptide |
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| 208 | BioGRID:107142 BioGRID:107027 ATR BioGRID PMID: 10608806 |
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| 209 | Affinity Capture-Western |
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| 210 | BioGRID:107142 BioGRID:114646 AURKB BioGRID PMID: 19176389 |
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| 211 | Affinity Capture-MS; Affinity Capture-Western; Co-purification |
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| 212 | BioGRID:107142 BioGRID:114946 BABAM2 BioGRID PMID: 14636569 |
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| 213 | Affinity Capture-MS |
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| 214 | BioGRID:107142 BioGRID:114906 BAG4 BioGRID PMID: 33961781,28514442 |
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| 215 | Affinity Capture-Western; Co-purification; Reconstituted Complex |
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| 216 | BioGRID:107142 BioGRID:107056 BARD1 BioGRID PMID: 19176389,17664283,16391231,14636569 |
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| 217 | Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid |
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| 218 | BioGRID:107142 BioGRID:121161 BCCIP BioGRID PMID: 15713648,11313963 |
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| 219 | Affinity Capture-MS |
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| 220 | BioGRID:107142 BioGRID:120155 BNC2 BioGRID PMID: 27433848 |
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| 221 | Affinity Capture-MS |
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| 222 | BioGRID:107142 BioGRID:610381 BORCS8 BioGRID PMID: 33961781 |
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| 223 | Affinity Capture-MS |
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| 224 | BioGRID:107142 BioGRID:127251 BPIFB4 BioGRID PMID: 27433848 |
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| 225 | Negative Genetic |
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| 226 | BioGRID:107142 BioGRID:107141 BRAF BioGRID PMID: 28319113 |
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| 227 | Affinity Capture-MS; Affinity Capture-Western; Co-purification; Proximity Label-MS; Reconstituted Complex; Two-hybrid |
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| 228 | BioGRID:107142 BioGRID:107140 BRCA1 BioGRID PMID: 34408138,29656893,25652403,25184681,24085845,21135251,19369211,17664283,14636569,14499622,11477095,9774970 |
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| 229 | Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex |
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| 230 | BioGRID:107142 BioGRID:107142 BRCA2 BioGRID PMID: 33978741,32609828,28168276,27433848 |
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| 231 | Affinity Capture-MS; Affinity Capture-Western; Co-purification |
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| 232 | BioGRID:107142 BioGRID:122599 BRCC3 BioGRID PMID: 17664283,14636569 |
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| 233 | Affinity Capture-Western |
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| 234 | BioGRID:107142 BioGRID:123841 BRIP1 BioGRID PMID: 17664283 |
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| 235 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
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| 236 | BioGRID:107142 BioGRID:107166 BUB1B BioGRID PMID: 32286328,28985013,10749118 |
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| 237 | Affinity Capture-MS |
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| 238 | BioGRID:107142 BioGRID:122822 C11orf80 BioGRID PMID: 27433848 |
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| 239 | Affinity Capture-MS |
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| 240 | BioGRID:107142 BioGRID:126429 C6orf141 BioGRID PMID: 33961781,28514442 |
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| 241 | Affinity Capture-MS |
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| 242 | BioGRID:107142 BioGRID:123628 CABLES2 BioGRID PMID: 27433848 |
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| 243 | Affinity Capture-MS |
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| 244 | BioGRID:107142 BioGRID:116564 CARD8 BioGRID PMID: 26186194 |
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| 245 | Affinity Capture-MS |
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| 246 | BioGRID:107142 BioGRID:107297 CAT BioGRID PMID: 27433848 |
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| 247 | Affinity Capture-MS |
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| 248 | BioGRID:107142 BioGRID:127217 CCDC24 BioGRID PMID: 27433848 |
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| 249 | Affinity Capture-MS |
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| 250 | BioGRID:107142 BioGRID:129209 CCDC96 BioGRID PMID: 33961781 |
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| 251 | Affinity Capture-Western; Reconstituted Complex |
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| 252 | BioGRID:107142 BioGRID:114417 CCNA1 BioGRID PMID: 26387543 |
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| 253 | Biochemical Activity |
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| 254 | BioGRID:107142 BioGRID:107331 CCNA2 BioGRID PMID: 15800615 |
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| 255 | Affinity Capture-Western |
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| 256 | BioGRID:107142 BioGRID:107332 CCNB1 BioGRID PMID: 26387543 |
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| 257 | Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex |
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| 258 | BioGRID:107142 BioGRID:107067 CCND1 BioGRID PMID: 26387543,21654808 |
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| 259 | Affinity Capture-MS |
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| 260 | BioGRID:107142 BioGRID:127265 CCT8L2 BioGRID PMID: 33961781 |
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| 261 | Affinity Capture-Western |
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| 262 | BioGRID:107142 BioGRID:113915 CDC45 BioGRID PMID: 22293751 |
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| 263 | Biochemical Activity |
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| 264 | BioGRID:107142 BioGRID:107452 CDK2 BioGRID PMID: 26387543,24835992,15800615 |
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| 265 | Negative Genetic |
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| 266 | BioGRID:107142 BioGRID:107459 CDK9 BioGRID PMID: 28319113 |
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| 267 | Affinity Capture-MS |
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| 268 | BioGRID:107142 BioGRID:116359 CELF3 BioGRID PMID: 27433848 |
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| 269 | Proximity Label-MS |
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| 270 | BioGRID:107142 BioGRID:115018 CEP135 BioGRID PMID: 34079125 |
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| 271 | Affinity Capture-MS |
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| 272 | BioGRID:107142 BioGRID:129077 CFAP299 BioGRID PMID: 27433848 |
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| 273 | Affinity Capture-Western |
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| 274 | BioGRID:107142 BioGRID:127014 CFAP52 BioGRID PMID: 15967112 |
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| 275 | Affinity Capture-MS |
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| 276 | BioGRID:107142 BioGRID:109324 CFH BioGRID PMID: 27433848 |
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| 277 | Biochemical Activity |
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| 278 | BioGRID:107142 BioGRID:107536 CHEK1 BioGRID PMID: 18317453 |
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| 279 | Affinity Capture-Western; Biochemical Activity; Protein-peptide |
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| 280 | BioGRID:107142 BioGRID:116369 CHEK2 BioGRID PMID: 18317453,17525332,14623252 |
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| 281 | Affinity Capture-MS |
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| 282 | BioGRID:107142 BioGRID:126170 CHMP4B BioGRID PMID: 27433848 |
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| 283 | Affinity Capture-MS |
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| 284 | BioGRID:107142 BioGRID:126226 CLHC1 BioGRID PMID: 27433848 |
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| 285 | Affinity Capture-MS |
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| 286 | BioGRID:107142 BioGRID:115550 CNKSR1 BioGRID PMID: 33961781,28514442 |
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| 287 | Affinity Capture-MS |
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| 288 | BioGRID:107142 BioGRID:107698 COL11A1 BioGRID PMID: 27433848 |
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| 289 | Affinity Capture-MS |
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| 290 | BioGRID:107142 BioGRID:107799 CRYAA BioGRID PMID: 33961781 |
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| 291 | Affinity Capture-MS |
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| 292 | BioGRID:107142 BioGRID:119274 CRYL1 BioGRID PMID: 33961781 |
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| 293 | Affinity Capture-Western |
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| 294 | BioGRID:107142 BioGRID:120304 CT55 BioGRID PMID: 18307534 |
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| 295 | Affinity Capture-MS |
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| 296 | BioGRID:107142 BioGRID:108332 CTTN BioGRID PMID: 35271311 |
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| 297 | Affinity Capture-MS |
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| 298 | BioGRID:107142 BioGRID:126821 CWF19L2 BioGRID PMID: 27433848 |
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| 299 | Affinity Capture-MS |
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| 300 | BioGRID:107142 BioGRID:126069 DCST2 BioGRID PMID: 27433848 |
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| 301 | Affinity Capture-MS |
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| 302 | BioGRID:107142 BioGRID:114204 DDX3Y BioGRID PMID: 27433848 |
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| 303 | Affinity Capture-MS |
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| 304 | BioGRID:107142 BioGRID:127768 DGKH BioGRID PMID: 27433848 |
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| 305 | Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid |
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| 306 | BioGRID:107142 BioGRID:116316 DMC1 BioGRID PMID: 26976601,20729832,17541404 |
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| 307 | Affinity Capture-MS |
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| 308 | BioGRID:107142 BioGRID:108109 DNAH9 BioGRID PMID: 27433848 |
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| 309 | Affinity Capture-MS |
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| 310 | BioGRID:107142 BioGRID:113117 DNAJC7 BioGRID PMID: 35271311 |
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| 311 | Affinity Capture-MS |
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| 312 | BioGRID:107142 BioGRID:131762 DPPA3 BioGRID PMID: 33961781,27433848 |
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| 313 | Affinity Capture-MS |
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| 314 | BioGRID:107142 BioGRID:123045 DSN1 BioGRID PMID: 33961781,28514442,26186194 |
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| 315 | Affinity Capture-MS |
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| 316 | BioGRID:107142 BioGRID:123857 DTNBP1 BioGRID PMID: 26186194 |
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| 317 | Affinity Capture-MS |
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| 318 | BioGRID:107142 BioGRID:123321 DUSP16 BioGRID PMID: 33961781 |
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| 319 | Affinity Capture-MS |
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| 320 | BioGRID:107142 BioGRID:126791 DYDC1 BioGRID PMID: 27433848 |
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| 321 | Affinity Capture-MS; Co-localization |
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| 322 | BioGRID:107142 BioGRID:108117 DYNC1H1 BioGRID PMID: 27433848 |
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| 323 | Affinity Capture-MS; Reconstituted Complex |
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| 324 | BioGRID:107142 BioGRID:119327 DYNC1LI1 BioGRID PMID: 27433848 |
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| 325 | Affinity Capture-MS; Reconstituted Complex |
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| 326 | BioGRID:107142 BioGRID:108120 DYNC1LI2 BioGRID PMID: 27433848 |
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| 327 | Affinity Capture-MS |
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| 328 | BioGRID:107142 BioGRID:134421 EEF1AKMT2 BioGRID PMID: 33961781 |
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| 329 | Affinity Capture-MS |
||
| 330 | BioGRID:107142 BioGRID:125185 EGLN3 BioGRID PMID: 26972000 |
||
| 331 | Affinity Capture-MS |
||
| 332 | BioGRID:107142 BioGRID:114407 EIF2B4 BioGRID PMID: 27433848 |
||
| 333 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
||
| 334 | BioGRID:107142 BioGRID:121270 EMSY BioGRID PMID: 14651845 |
||
| 335 | Affinity Capture-Western; Reconstituted Complex |
||
| 336 | BioGRID:107142 BioGRID:108385 ERCC5 BioGRID PMID: 26833090 |
||
| 337 | Affinity Capture-MS; Affinity Capture-Western |
||
| 338 | BioGRID:107142 BioGRID:119971 ETAA1 BioGRID PMID: 27723720 |
||
| 339 | Affinity Capture-MS |
||
| 340 | BioGRID:107142 BioGRID:108455 F8 BioGRID PMID: 27433848 |
||
| 341 | Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid |
||
| 342 | BioGRID:107142 BioGRID:108474 FANCD2 BioGRID PMID: 31180492,28684355,20450923,19861535,18263878,18212739,15199141,15115758 |
||
| 343 | Affinity Capture-Western |
||
| 344 | BioGRID:107142 BioGRID:108475 FANCE BioGRID PMID: 15199141 |
||
| 345 | Affinity Capture-Western; Two-hybrid |
||
| 346 | BioGRID:107142 BioGRID:108484 FANCG BioGRID PMID: 20450923,18212739,16621732,12915460 |
||
| 347 | Two-hybrid |
||
| 348 | BioGRID:107142 BioGRID:120511 FANCI BioGRID PMID: 28684355 |
||
| 349 | Affinity Capture-MS |
||
| 350 | BioGRID:107142 BioGRID:128792 FBXL13 BioGRID PMID: 29348145 |
||
| 351 | Affinity Capture-MS |
||
| 352 | BioGRID:107142 BioGRID:115225 FIG4 BioGRID PMID: 27433848 |
||
| 353 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
||
| 354 | BioGRID:107142 BioGRID:108605 FLNA BioGRID PMID: 11602572 |
||
| 355 | Affinity Capture-MS |
||
| 356 | BioGRID:107142 BioGRID:113921 FZD8 BioGRID PMID: 27433848 |
||
| 357 | Affinity Capture-MS |
||
| 358 | BioGRID:107142 BioGRID:129644 GOLGA6L2 BioGRID PMID: 33961781 |
||
| 359 | Affinity Capture-MS |
||
| 360 | BioGRID:107142 BioGRID:136572 GPR179 BioGRID PMID: 27433848 |
||
| 361 | Affinity Capture-MS |
||
| 362 | BioGRID:107142 BioGRID:123059 GREB1L BioGRID PMID: 27433848 |
||
| 363 | Affinity Capture-MS |
||
| 364 | BioGRID:107142 BioGRID:137113 GUSBP5 BioGRID PMID: 33961781 |
||
| 365 | Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex |
||
| 366 | BioGRID:107142 BioGRID:109268 H2AX BioGRID PMID: 20936109,18406329 |
||
| 367 | Proximity Label-MS |
||
| 368 | BioGRID:107142 BioGRID:109315 HDAC1 BioGRID PMID: 34709266 |
||
| 369 | Negative Genetic |
||
| 370 | BioGRID:107142 BioGRID:115330 HDAC6 BioGRID PMID: 28319113 |
||
| 371 | Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex |
||
| 372 | BioGRID:107142 BioGRID:115642 HMG20B BioGRID PMID: 25486196,21399666,12032298,11207365 |
||
| 373 | Protein-RNA |
||
| 374 | BioGRID:107142 BioGRID:109424 HNRNPC BioGRID PMID: 23585894 |
||
| 375 | Affinity Capture-MS |
||
| 376 | BioGRID:107142 BioGRID:127652 HSD17B7P2 BioGRID PMID: 33961781 |
||
| 377 | Affinity Capture-MS |
||
| 378 | BioGRID:107142 BioGRID:116260 HSF2BP BioGRID PMID: 33961781 |
||
| 379 | Affinity Capture-MS |
||
| 380 | BioGRID:107142 BioGRID:109552 HSP90AA1 BioGRID PMID: 35271311 |
||
| 381 | Affinity Capture-MS |
||
| 382 | BioGRID:107142 BioGRID:109558 HSP90AB1 BioGRID PMID: 35271311 |
||
| 383 | Affinity Capture-MS |
||
| 384 | BioGRID:107142 BioGRID:113036 HSP90B1 BioGRID PMID: 27433848 |
||
| 385 | Affinity Capture-MS |
||
| 386 | BioGRID:107142 BioGRID:109540 HSPA4 BioGRID PMID: 35271311 |
||
| 387 | Affinity Capture-MS |
||
| 388 | BioGRID:107142 BioGRID:117689 HSPB8 BioGRID PMID: 33961781,32707033,28514442 |
||
| 389 | Affinity Capture-MS |
||
| 390 | BioGRID:107142 BioGRID:114959 IER2 BioGRID PMID: 26186194 |
||
| 391 | Affinity Capture-Western; Reconstituted Complex |
||
| 392 | BioGRID:107142 BioGRID:114375 KAT2B BioGRID PMID: 28985013,12815053,9824164 |
||
| 393 | Proximity Label-MS |
||
| 394 | BioGRID:107142 BioGRID:116667 KDM1A BioGRID PMID: 34709266 |
||
| 395 | Negative Genetic |
||
| 396 | BioGRID:107142 BioGRID:113870 KDM5C BioGRID PMID: 28319113 |
||
| 397 | Affinity Capture-MS; Affinity Capture-Western |
||
| 398 | BioGRID:107142 BioGRID:115156 KEAP1 BioGRID PMID: 28416489,22331464 |
||
| 399 | Affinity Capture-Western |
||
| 400 | BioGRID:107142 BioGRID:117288 KIF4A BioGRID PMID: 18604178 |
||
| 401 | Affinity Capture-MS |
||
| 402 | BioGRID:107142 BioGRID:126278 KLHL40 BioGRID PMID: 33961781 |
||
| 403 | Affinity Capture-MS |
||
| 404 | BioGRID:107142 BioGRID:110047 KRT2 BioGRID PMID: 33961781 |
||
| 405 | Affinity Capture-MS |
||
| 406 | BioGRID:107142 BioGRID:114234 KRT38 BioGRID PMID: 33961781 |
||
| 407 | Affinity Capture-MS |
||
| 408 | BioGRID:107142 BioGRID:128199 KRT78 BioGRID PMID: 33961781 |
||
| 409 | Affinity Capture-MS |
||
| 410 | BioGRID:107142 BioGRID:117486 L3MBTL1 BioGRID PMID: 33961781,28514442 |
||
| 411 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
||
| 412 | BioGRID:107142 BioGRID:114475 LIMD1 BioGRID PMID: 27656835 |
||
| 413 | Co-localization |
||
| 414 | BioGRID:107142 BioGRID:110186 LMNA BioGRID PMID: 30419336 |
||
| 415 | Affinity Capture-MS |
||
| 416 | BioGRID:107142 BioGRID:3193615 LOC101930047 BioGRID PMID: 27433848 |
||
| 417 | Affinity Capture-MS |
||
| 418 | BioGRID:107142 BioGRID:125700 LRRK2 BioGRID PMID: 27433848 |
||
| 419 | Proximity Label-MS |
||
| 420 | BioGRID:107142 BioGRID:124083 LZTS2 BioGRID PMID: 29395067 |
||
| 421 | Affinity Capture-MS |
||
| 422 | BioGRID:107142 BioGRID:110282 MAGEA9 BioGRID PMID: 33961781 |
||
| 423 | Two-hybrid |
||
| 424 | BioGRID:107142 BioGRID:114879 MAGED1 BioGRID PMID: 15930293 |
||
| 425 | Affinity Capture-MS |
||
| 426 | BioGRID:107142 BioGRID:111583 MAPK6 BioGRID PMID: 26972000 |
||
| 427 | Affinity Capture-Western; Co-localization |
||
| 428 | BioGRID:107142 BioGRID:122776 MCPH1 BioGRID PMID: 20107607,19549900 |
||
| 429 | Proximity Label-MS |
||
| 430 | BioGRID:107142 BioGRID:115014 MDC1 BioGRID PMID: 29656893 |
||
| 431 | Affinity Capture-MS |
||
| 432 | BioGRID:107142 BioGRID:119002 MDFIC BioGRID PMID: 27433848 |
||
| 433 | Affinity Capture-MS |
||
| 434 | BioGRID:107142 BioGRID:122938 MFSD13A BioGRID PMID: 27433848 |
||
| 435 | Affinity Capture-Western |
||
| 436 | BioGRID:107142 BioGRID:110411 MGMT BioGRID PMID: 19047179 |
||
| 437 | Affinity Capture-MS |
||
| 438 | BioGRID:107142 BioGRID:120019 MIER2 BioGRID PMID: 26186194 |
||
| 439 | Affinity Capture-MS |
||
| 440 | BioGRID:107142 BioGRID:110437 MLF1 BioGRID PMID: 33961781,28514442,26186194 |
||
| 441 | Affinity Capture-MS |
||
| 442 | BioGRID:107142 BioGRID:110462 MMP10 BioGRID PMID: 27433848 |
||
| 443 | Affinity Capture-MS; Affinity Capture-Western |
||
| 444 | BioGRID:107142 BioGRID:116134 MORF4L1 BioGRID PMID: 33961781,26186194,20332121 |
||
| 445 | Affinity Capture-MS |
||
| 446 | BioGRID:107142 BioGRID:115001 MORF4L2 BioGRID PMID: 33961781,28514442 |
||
| 447 | Affinity Capture-MS |
||
| 448 | BioGRID:107142 BioGRID:114558 MTMR6 BioGRID PMID: 27433848 |
||
| 449 | Affinity Capture-Western; Co-fractionation |
||
| 450 | BioGRID:107142 BioGRID:122884 MYH14 BioGRID PMID: 24448238 |
||
| 451 | Affinity Capture-MS |
||
| 452 | BioGRID:107142 BioGRID:124254 NAA11 BioGRID PMID: 33961781 |
||
| 453 | Affinity Capture-MS |
||
| 454 | BioGRID:107142 BioGRID:118913 NCAPH2 BioGRID PMID: 33961781,28514442 |
||
| 455 | Affinity Capture-MS |
||
| 456 | BioGRID:107142 BioGRID:131288 NCKAP5 BioGRID PMID: 27433848 |
||
| 457 | Proximity Label-MS |
||
| 458 | BioGRID:107142 BioGRID:110771 NCL BioGRID PMID: 30021884 |
||
| 459 | Protein-peptide |
||
| 460 | BioGRID:107142 BioGRID:110811 NEDD4 BioGRID PMID: 15001356 |
||
| 461 | Proximity Label-MS |
||
| 462 | BioGRID:107142 BioGRID:119372 NIN BioGRID PMID: 28718761 |
||
| 463 | Proximity Label-MS |
||
| 464 | BioGRID:107142 BioGRID:116630 NINL BioGRID PMID: 28718761 |
||
| 465 | Affinity Capture-MS; Affinity Capture-Western |
||
| 466 | BioGRID:107142 BioGRID:110929 NPM1 BioGRID PMID: 21084279 |
||
| 467 | Positive Genetic |
||
| 468 | BioGRID:107142 BioGRID:110942 NPR2 BioGRID PMID: 28319085 |
||
| 469 | Positive Genetic |
||
| 470 | BioGRID:107142 BioGRID:111532 NPY4R BioGRID PMID: 28319085 |
||
| 471 | Affinity Capture-MS |
||
| 472 | BioGRID:107142 BioGRID:117433 NSL1 BioGRID PMID: 26186194 |
||
| 473 | Affinity Capture-MS |
||
| 474 | BioGRID:107142 BioGRID:120147 NSMCE4A BioGRID PMID: 33961781,28514442,26186194 |
||
| 475 | Affinity Capture-MS |
||
| 476 | BioGRID:107142 BioGRID:111033 OPRM1 BioGRID PMID: 27433848 |
||
| 477 | Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex |
||
| 478 | BioGRID:107142 BioGRID:122843 PALB2 BioGRID PMID: 34591612,33961781,28765325,28398198,28319063,28240985,26990772,26833090,26649820,25016020,24835992,24141787,23585894,23038782,22331464,22293751,22193777,21466675,20871615,20332121,19609323,19584259,19553677,19369211,19268590,17200672,16793542 |
||
| 479 | Synthetic Lethality |
||
| 480 | BioGRID:107142 BioGRID:106652 PARP1 BioGRID PMID: 28628639,27453043 |
||
| 481 | Synthetic Lethality |
||
| 482 | BioGRID:107142 BioGRID:115350 PARP2 BioGRID PMID: 28628639 |
||
| 483 | Affinity Capture-Western |
||
| 484 | BioGRID:107142 BioGRID:111142 PCNA BioGRID PMID: 22293751 |
||
| 485 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
||
| 486 | BioGRID:107142 BioGRID:116685 PDS5B BioGRID PMID: 27924011,22293751 |
||
| 487 | Proximity Label-MS |
||
| 488 | BioGRID:107142 BioGRID:119468 PHF21A BioGRID PMID: 34709266 |
||
| 489 | Negative Genetic |
||
| 490 | BioGRID:107142 BioGRID:111330 PKLR BioGRID PMID: 28319085 |
||
| 491 | Affinity Capture-Western; Co-fractionation; Reconstituted Complex |
||
| 492 | BioGRID:107142 BioGRID:111355 PLEC BioGRID PMID: 19709076 |
||
| 493 | Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Far Western; Reconstituted Complex |
||
| 494 | BioGRID:107142 BioGRID:111362 PLK1 BioGRID PMID: 32286328,28985013,24835992,24448238,14647413,12815053 |
||
| 495 | Affinity Capture-Western |
||
| 496 | BioGRID:107142 BioGRID:111391 PMS1 BioGRID PMID: 17148452 |
||
| 497 | Affinity Capture-MS |
||
| 498 | BioGRID:107142 BioGRID:111404 PMS2 BioGRID PMID: 17148452 |
||
| 499 | Affinity Capture-MS |
||
| 500 | BioGRID:107142 BioGRID:124398 PNMA6A BioGRID PMID: 33961781 |
||
| 501 | Affinity Capture-Western; Co-localization; Reconstituted Complex |
||
| 502 | BioGRID:107142 BioGRID:111425 POLH BioGRID PMID: 24485656 |
||
| 503 | Affinity Capture-MS |
||
| 504 | BioGRID:107142 BioGRID:131695 POLN BioGRID PMID: 26269593 |
||
| 505 | Proximity Label-MS |
||
| 506 | BioGRID:107142 BioGRID:122173 POLR1E BioGRID PMID: 34079125 |
||
| 507 | Affinity Capture-Western |
||
| 508 | BioGRID:107142 BioGRID:111426 POLR2A BioGRID PMID: 29386125 |
||
| 509 | Affinity Capture-MS |
||
| 510 | BioGRID:107142 BioGRID:117979 PPA2 BioGRID PMID: 27433848 |
||
| 511 | Affinity Capture-MS |
||
| 512 | BioGRID:107142 BioGRID:116515 PPM1E BioGRID PMID: 33961781,28514442 |
||
| 513 | Affinity Capture-MS |
||
| 514 | BioGRID:107142 BioGRID:116054 PPP1R17 BioGRID PMID: 27433848 |
||
| 515 | Affinity Capture-Western |
||
| 516 | BioGRID:107142 BioGRID:111507 PPP2CA BioGRID PMID: 28985013 |
||
| 517 | Affinity Capture-MS |
||
| 518 | BioGRID:107142 BioGRID:120646 PPP4R1L BioGRID PMID: 33961781 |
||
| 519 | Affinity Capture-MS |
||
| 520 | BioGRID:107142 BioGRID:127516 PRELID2 BioGRID PMID: 33961781 |
||
| 521 | Affinity Capture-Western |
||
| 522 | BioGRID:107142 BioGRID:111682 PSMD3 BioGRID PMID: 17563742 |
||
| 523 | Affinity Capture-Western |
||
| 524 | BioGRID:107142 BioGRID:115195 PSMD6 BioGRID PMID: 17563742 |
||
| 525 | Affinity Capture-MS |
||
| 526 | BioGRID:107142 BioGRID:115952 PTGES3 BioGRID PMID: 33961781 |
||
| 527 | Affinity Capture-Western |
||
| 528 | BioGRID:107142 BioGRID:111516 PTPA BioGRID PMID: 32286328 |
||
| 529 | Affinity Capture-MS |
||
| 530 | BioGRID:107142 BioGRID:111795 PYGM BioGRID PMID: 27433848 |
||
| 531 | Affinity Capture-Western; Co-fractionation |
||
| 532 | BioGRID:107142 BioGRID:231454 Palb2 BioGRID PMID: 25016020 |
||
| 533 | Affinity Capture-MS |
||
| 534 | BioGRID:107142 BioGRID:116330 RABL2A BioGRID PMID: 28514442,26186194 |
||
| 535 | Affinity Capture-Western |
||
| 536 | BioGRID:107142 BioGRID:111822 RAD21 BioGRID PMID: 22293751 |
||
| 537 | Affinity Capture-MS |
||
| 538 | BioGRID:107142 BioGRID:111823 RAD23A BioGRID PMID: 16712842 |
||
| 539 | Affinity Capture-Western |
||
| 540 | BioGRID:107142 BioGRID:115417 RAD50 BioGRID PMID: 20010693 |
||
| 541 | Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Co-purification; Protein-peptide; Reconstituted Complex; Two-hybrid |
||
| 542 | BioGRID:107142 BioGRID:111825 RAD51 BioGRID PMID: 35061896,33476590,31113933,28765325,28757209,28168276,27941124,26833090,26387543,26145171,25585578,24981860,24835992,24013206,23935068,22293751,21789034,21670257,21601571,21399666,21076401,20871615,20729859,20729832,19875419,19303847,18429819,18317453,17541404,17515904,17515903,16914443,16793542,16513631,15937124,15897881,15800615,15713648,15671039,15065660,14636569,14580352,12941707,12815053,12606939,12442171,11477095,11313963,11239456,10551859,9811893,9774970,9560268,9523196,9405383,9126738 |
||
| 543 | Affinity Capture-MS; Affinity Capture-Western |
||
| 544 | BioGRID:107142 BioGRID:111826 RAD51C BioGRID PMID: 24141787 |
||
| 545 | Phenotypic Enhancement |
||
| 546 | BioGRID:107142 BioGRID:111830 RAD52 BioGRID PMID: 31799622 |
||
| 547 | Proximity Label-MS |
||
| 548 | BioGRID:107142 BioGRID:116796 RCOR1 BioGRID PMID: 34709266 |
||
| 549 | Synthetic Growth Defect |
||
| 550 | BioGRID:107142 BioGRID:114797 RECQL5 BioGRID PMID: 24418621 |
||
| 551 | Affinity Capture-MS |
||
| 552 | BioGRID:107142 BioGRID:121661 RELCH BioGRID PMID: 27433848 |
||
| 553 | Affinity Capture-MS |
||
| 554 | BioGRID:107142 BioGRID:114180 RFXANK BioGRID PMID: 28514442 |
||
| 555 | Affinity Capture-Western; Co-localization; Protein-peptide; Reconstituted Complex |
||
| 556 | BioGRID:107142 BioGRID:115789 RNASEH2A BioGRID PMID: 30560944 |
||
| 557 | Affinity Capture-Western |
||
| 558 | BioGRID:107142 BioGRID:127922 RNF168 BioGRID PMID: 28240985 |
||
| 559 | Affinity Capture-MS; Affinity Capture-Western |
||
| 560 | BioGRID:107142 BioGRID:114860 ROCK2 BioGRID PMID: 21084279 |
||
| 561 | Affinity Capture-Western; Reconstituted Complex |
||
| 562 | BioGRID:107142 BioGRID:112037 RPA1 BioGRID PMID: 12527904 |
||
| 563 | Co-localization |
||
| 564 | BioGRID:107142 BioGRID:112038 RPA2 BioGRID PMID: 25113031 |
||
| 565 | Affinity Capture-MS |
||
| 566 | BioGRID:107142 BioGRID:116566 RUFY3 BioGRID PMID: 27433848 |
||
| 567 | Two-hybrid |
||
| 568 | BioGRID:107142 BioGRID:202564 Rad51 BioGRID PMID: 9126738 |
||
| 569 | Affinity Capture-MS |
||
| 570 | BioGRID:107142 BioGRID:131928 SAXO5 BioGRID PMID: 33961781,28514442 |
||
| 571 | Affinity Capture-MS |
||
| 572 | BioGRID:107142 BioGRID:119334 SDF4 BioGRID PMID: 26186194 |
||
| 573 | Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex; Two-hybrid |
||
| 574 | BioGRID:107142 BioGRID:113692 SEM1 BioGRID PMID: 33978741,32609828,28976962,26833090,26145171,16239144,16205630,12228710,10373512 |
||
| 575 | Reconstituted Complex |
||
| 576 | BioGRID:107142 BioGRID:107318 SERPINH1 BioGRID PMID: 19578754 |
||
| 577 | Affinity Capture-MS |
||
| 578 | BioGRID:107142 BioGRID:119171 SHANK1 BioGRID PMID: 27433848 |
||
| 579 | Affinity Capture-MS |
||
| 580 | BioGRID:107142 BioGRID:120024 SHLD2 BioGRID PMID: 27433848 |
||
| 581 | Affinity Capture-MS |
||
| 582 | BioGRID:107142 BioGRID:127380 SLC16A14 BioGRID PMID: 27433848 |
||
| 583 | Affinity Capture-MS |
||
| 584 | BioGRID:107142 BioGRID:118182 SLCO1B3 BioGRID PMID: 27433848 |
||
| 585 | Affinity Capture-Western |
||
| 586 | BioGRID:107142 BioGRID:110262 SMAD2 BioGRID PMID: 12165866 |
||
| 587 | Affinity Capture-Western; Reconstituted Complex |
||
| 588 | BioGRID:107142 BioGRID:110263 SMAD3 BioGRID PMID: 12165866 |
||
| 589 | Negative Genetic |
||
| 590 | BioGRID:107142 BioGRID:112482 SMARCB1 BioGRID PMID: 28319113 |
||
| 591 | Affinity Capture-Western |
||
| 592 | BioGRID:107142 BioGRID:114574 SMC3 BioGRID PMID: 22293751 |
||
| 593 | Affinity Capture-MS |
||
| 594 | BioGRID:107142 BioGRID:129016 SNX32 BioGRID PMID: 33961781,28514442 |
||
| 595 | Affinity Capture-MS |
||
| 596 | BioGRID:107142 BioGRID:121852 SNX6 BioGRID PMID: 33961781 |
||
| 597 | Affinity Capture-Western |
||
| 598 | BioGRID:107142 BioGRID:112550 SP1 BioGRID PMID: 18769160 |
||
| 599 | Affinity Capture-MS |
||
| 600 | BioGRID:107142 BioGRID:119032 SPANXA1 BioGRID PMID: 33961781,28514442 |
||
| 601 | Negative Genetic |
||
| 602 | BioGRID:107142 BioGRID:121208 SPHK2 BioGRID PMID: 28319085 |
||
| 603 | Affinity Capture-Western |
||
| 604 | BioGRID:107142 BioGRID:112653 STAT5A BioGRID PMID: 12459499 |
||
| 605 | Affinity Capture-MS |
||
| 606 | BioGRID:107142 BioGRID:118941 STRN4 BioGRID PMID: 27433848 |
||
| 607 | Affinity Capture-MS |
||
| 608 | BioGRID:107142 BioGRID:114042 SUPT3H BioGRID PMID: 27433848 |
||
| 609 | Proximity Label-MS |
||
| 610 | BioGRID:107142 BioGRID:127775 SYNE3 BioGRID PMID: 34079125 |
||
| 611 | Affinity Capture-MS |
||
| 612 | BioGRID:107142 BioGRID:112870 TEP1 BioGRID PMID: 27433848 |
||
| 613 | Proximity Label-MS |
||
| 614 | BioGRID:107142 BioGRID:119942 TERF2IP BioGRID PMID: 34079125 |
||
| 615 | Affinity Capture-MS |
||
| 616 | BioGRID:107142 BioGRID:112874 TERT BioGRID PMID: 27433848 |
||
| 617 | Affinity Capture-MS |
||
| 618 | BioGRID:107142 BioGRID:117460 TIPARP BioGRID PMID: 35439318 |
||
| 619 | Synthetic Lethality |
||
| 620 | BioGRID:107142 BioGRID:113003 TOP1 BioGRID PMID: 27453043 |
||
| 621 | Synthetic Lethality |
||
| 622 | BioGRID:107142 BioGRID:113006 TOP2A BioGRID PMID: 27453043 |
||
| 623 | Synthetic Lethality |
||
| 624 | BioGRID:107142 BioGRID:113009 TOP3A BioGRID PMID: 27453043 |
||
| 625 | Affinity Capture-MS; Affinity Capture-Western; Co-purification; Proximity Label-MS; Reconstituted Complex |
||
| 626 | BioGRID:107142 BioGRID:113010 TP53 BioGRID PMID: 34795231,32807901,20421506,14636569,9811893 |
||
| 627 | Proximity Label-MS; Reconstituted Complex |
||
| 628 | BioGRID:107142 BioGRID:113011 TP53BP1 BioGRID PMID: 29656893,20010693 |
||
| 629 | Negative Genetic |
||
| 630 | BioGRID:107142 BioGRID:113029 TPSAB1 BioGRID PMID: 28319085 |
||
| 631 | Affinity Capture-MS |
||
| 632 | BioGRID:107142 BioGRID:117177 TRIM29 BioGRID PMID: 26095369 |
||
| 633 | Affinity Capture-MS |
||
| 634 | BioGRID:107142 BioGRID:124301 TRIM52 BioGRID PMID: 33961781 |
||
| 635 | Affinity Capture-MS |
||
| 636 | BioGRID:107142 BioGRID:129021 TSGA10IP BioGRID PMID: 33961781 |
||
| 637 | Affinity Capture-MS |
||
| 638 | BioGRID:107142 BioGRID:114036 TTF2 BioGRID PMID: 27433848 |
||
| 639 | Negative Genetic |
||
| 640 | BioGRID:107142 BioGRID:113148 TYK2 BioGRID PMID: 28319085 |
||
| 641 | Co-localization |
||
| 642 | BioGRID:107142 BioGRID:119697 UIMC1 BioGRID PMID: 29499138 |
||
| 643 | Affinity Capture-MS |
||
| 644 | BioGRID:107142 BioGRID:113224 UPP1 BioGRID PMID: 33961781 |
||
| 645 | Reconstituted Complex |
||
| 646 | BioGRID:107142 BioGRID:120536 UQCC1 BioGRID PMID: 19578754 |
||
| 647 | Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity |
||
| 648 | BioGRID:107142 BioGRID:113866 USP11 BioGRID PMID: 15314155 |
||
| 649 | Affinity Capture-Western; Biochemical Activity |
||
| 650 | BioGRID:107142 BioGRID:117950 USP21 BioGRID PMID: 28743957 |
||
| 651 | Affinity Capture-MS |
||
| 652 | BioGRID:107142 BioGRID:115073 UTP14C BioGRID PMID: 27433848 |
||
| 653 | Affinity Capture-RNA |
||
| 654 | BioGRID:107142 BioGRID:117452 VIRMA BioGRID PMID: 29507755 |
||
| 655 | Affinity Capture-MS |
||
| 656 | BioGRID:107142 BioGRID:119341 VPS28 BioGRID PMID: 26186194 |
||
| 657 | Affinity Capture-Western; Reconstituted Complex |
||
| 658 | BioGRID:107142 BioGRID:125985 WTIP BioGRID PMID: 27535760 |
||
| 659 | Reconstituted Complex |
||
| 660 | BioGRID:107142 BioGRID:113348 XPO1 BioGRID PMID: 24013206 |
||
| 661 | Affinity Capture-MS; Affinity Capture-Western |
||
| 662 | BioGRID:107142 BioGRID:113351 XRCC3 BioGRID PMID: 26496610,20450923,18212739,16621732 |
||
| 663 | Affinity Capture-MS |
||
| 664 | BioGRID:107142 BioGRID:124306 ZNF503 BioGRID PMID: 27433848 |
||
| 665 | Affinity Capture-MS |
||
| 666 | BioGRID:107142 BioGRID:130290 ZNF707 BioGRID PMID: 27433848 |
||
| 667 | Affinity Capture-MS |
||
| 668 | BioGRID:107142 BioGRID:136714 ZYG11A BioGRID PMID: 27433848 |
||
| 669 | Reconstituted Complex |
||
| 670 | BioGRID:107142 BioGRID:98493 rad51.L BioGRID PMID: 21719678 |
||
| 671 | |||
| 672 | GENERAL GENE INFO |
||
| 673 | ------------------------------------------------------------------------------------------------- |
||
| 674 | |||
| 675 | Marker |
||
| 676 | PMC13918P2 (e-PCR) Links:UniSTS:270878 |
||
| 677 | PMC13918P3 (e-PCR) Links:UniSTS:270879 |
||
| 678 | PMC13918P4 (e-PCR) Links:UniSTS:270880 |
||
| 679 | PMC13918P5 (e-PCR) Links:UniSTS:270881 |
||
| 680 | PMC13918P6 (e-PCR) Links:UniSTS:270882 |
||
| 681 | D13S1788 (e-PCR) Links:UniSTS:474668 |
||
| 682 | STS-X95157 (e-PCR) Links:UniSTS:27960 |
||
| 683 | REN34178 (e-PCR) Links:UniSTS:358978 |
||
| 684 | PMC23830P1 (e-PCR) Links:UniSTS:272209 |
||
| 685 | G48219 (e-PCR) Links:UniSTS:95316 |
||
| 686 | STS-X95152 (e-PCR) Links:UniSTS:50804 |
||
| 687 | PMC310899P14 (e-PCR) Links:UniSTS:272803 |
||
| 688 | RH68440 (e-PCR) Links:UniSTS:34471 |
||
| 689 | BRCA2 (e-PCR) Links:UniSTS:505289 |
||
| 690 | SHGC-81356 (e-PCR) Links:UniSTS:103159 |
||
| 691 | |||
| 692 | |||
| 693 | Homology |
||
| 694 | Homologs of the BRCA2 gene |
||
| 695 | The BRCA2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. |
||
| 696 | Orthologs from Annotation Pipeline (/gene/?Term=ortholog_gene_675[group]): |
||
| 697 | Orthologs |
||
| 698 | |||
| 699 | Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA) |
||
| 700 | |||
| 701 | Function GO ID Evidence |
||
| 702 | ------------------------------------------------------------------------------------------------- |
||
| 703 | enables gamma-tubulin binding GO:0000000 PMID: 17286961 |
||
| 704 | enables histone H3 acetyltransferase act... GO:0000000 PMID: 9619837 |
||
| 705 | enables histone H4 acetyltransferase act... GO:0000000 PMID: 9619837 |
||
| 706 | NOT enables histone acetyltransferase ac... GO:0000000 PMID: 9824164 |
||
| 707 | enables identical protein binding GO:0000000 PMID: 21601571,25282148 |
||
| 708 | enables protease binding GO:0000000 PMID: 15314155 |
||
| 709 | enables protein binding GO:0000000 PMID: 9774970 |
||
| 710 | enables protein binding GO:0000000 PMID: 9560268,9774970,10373512,10551859,11597317,12242698,12442171,15115758,15800615,15930293,15967112,16099937,16205630,16275750,17420451,17515903,17515904,17541404,18212739,18264088,19303847,19369211,19423707,19609323,19628690,20421506,20729832,20729859,21399666,21601571,21719596,22116401,22193777,22293751,24013206,24141787,24485656,24981860,25282148,25585578,26649820,26833090,28319063,30410870,31242413,34591612 |
||
| 711 | enables single-stranded DNA binding GO:0000000 PMID: 20729832 |
||
| 712 | |||
| 713 | Processs GO ID Evidence |
||
| 714 | ------------------------------------------------------------------------------------------------- |
||
| 715 | involved_in DNA damage response, signal ... GO:0000000 - |
||
| 716 | involved_in brain development GO:0000000 - |
||
| 717 | involved_in cellular response to ionizin... GO:0000000 PMID: 14636569 |
||
| 718 | involved_in cellular senescence GO:0000000 - |
||
| 719 | involved_in centrosome duplication GO:0000000 PMID: 17286961 |
||
| 720 | involved_in chromatin remodeling GO:0000000 - |
||
| 721 | involved_in double-strand break repair GO:0000000 PMID: 16845393 |
||
| 722 | involved_in double-strand break repair v... GO:0000000 PMID: 21873635 |
||
| 723 | involved_in double-strand break repair v... GO:0000000 PMID: 20729832,28398198 |
||
| 724 | involved_in double-strand break repair v... GO:0000000 PMID: 21719596 |
||
| 725 | involved_in establishment of protein loc... GO:0000000 PMID: 21076401 |
||
| 726 | involved_in female gonad development GO:0000000 - |
||
| 727 | involved_in hematopoietic stem cell prol... GO:0000000 - |
||
| 728 | involved_in histone H2A monoubiquitinati... GO:0000000 PMID: 12485996 |
||
| 729 | involved_in inner cell mass cell prolife... GO:0000000 - |
||
| 730 | involved_in intrinsic apoptotic signalin... GO:0000000 - |
||
| 731 | involved_in male meiosis I GO:0000000 - |
||
| 732 | involved_in mitotic recombination-depend... GO:0000000 PMID: 21076401 |
||
| 733 | involved_in negative regulation of mamma... GO:0000000 PMID: 15930293 |
||
| 734 | involved_in nucleotide-excision repair GO:0000000 PMID: 16845393 |
||
| 735 | involved_in oocyte maturation GO:0000000 - |
||
| 736 | involved_in positive regulation of DNA-t... GO:0000000 PMID: 9126734 |
||
| 737 | involved_in positive regulation of mitot... GO:0000000 - |
||
| 738 | involved_in protein autoubiquitination GO:0000000 PMID: 12485996 |
||
| 739 | involved_in regulation of DNA damage che... GO:0000000 PMID: 14636569 |
||
| 740 | involved_in regulation of DNA-templated ... GO:0000000 PMID: 21873635 |
||
| 741 | involved_in regulation of cytokinesis GO:0000000 - |
||
| 742 | involved_in response to UV-C GO:0000000 - |
||
| 743 | involved_in response to X-ray GO:0000000 - |
||
| 744 | involved_in response to gamma radiation GO:0000000 - |
||
| 745 | involved_in spermatogenesis GO:0000000 - |
||
| 746 | involved_in telomere maintenance via rec... GO:0000000 - |
||
| 747 | |||
| 748 | Component GO ID Evidence |
||
| 749 | ------------------------------------------------------------------------------------------------- |
||
| 750 | part_of BRCA2-MAGE-D1 complex GO:0000000 PMID: 15930293 |
||
| 751 | part_of DNA repair complex GO:0000000 PMID: 19369211 |
||
| 752 | located_in centrosome GO:0000000 PMID: 17286961,21276791 |
||
| 753 | located_in chromosome, telomeric region GO:0000000 PMID: 21076401 |
||
| 754 | located_in cytosol GO:0000000 - |
||
| 755 | located_in cytosol GO:0000000 - |
||
| 756 | located_in lateral element GO:0000000 PMID: 9774970 |
||
| 757 | part_of nuclear ubiquitin ligase complex GO:0000000 PMID: 14636569 |
||
| 758 | located_in nucleoplasm GO:0000000 - |
||
| 759 | located_in nucleoplasm GO:0000000 - |
||
| 760 | is_active_in nucleus GO:0000000 PMID: 21873635 |
||
| 761 | located_in nucleus GO:0000000 PMID: 9560268,9774970,14636569,17286961,26833090 |
||
| 762 | located_in nucleus GO:0000000 PMID: 19369211 |
||
| 763 | part_of protein-containing complex GO:0000000 PMID: 9774970,26833090 |
||
| 764 | located_in secretory granule GO:0000000 PMID: 8589722 |
||
| 765 | |||
| 766 | GENERAL PROTEIN INFORMATION |
||
| 767 | ------------------------------------------------------------------------------------------------- |
||
| 768 | Preferred Names |
||
| 769 | breast cancer type 2 susceptibility protein |
||
| 770 | Names |
||
| 771 | BRCA1/BRCA2-containing complex, subunit 2 |
||
| 772 | DNA repair-associated BRCA2 |
||
| 773 | Fanconi anemia group D1 protein |
||
| 774 | breast and ovarian cancer susceptibility gene, early onset |
||
| 775 | breast and ovarian cancer susceptibility protein 2 |
||
| 776 | breast cancer 2 tumor suppressor |
||
| 777 | breast cancer 2, early onset |
||
| 778 | mutant BRCA2 |
||
| 779 | mutant DNA repair-associated protein 2 |
||
| 780 | |||
| 781 | NCBI REFERENCE SEQUENCES (RefSeq) |
||
| 782 | ------------------------------------------------------------------------------------------------- |
||
| 783 | |||
| 784 | RefSeqs maintained independently of Annotated Genomes |
||
| 785 | |||
| 786 | These reference sequences exist independently of genome builds. |
||
| 787 | These reference sequences are curated independently of the genome annotation cycle, |
||
| 788 | so their versions may not match the RefSeq versions in the current genome build. |
||
| 789 | Identify version mismatches by comparing the version of the RefSeq in this section to |
||
| 790 | the one reported in Genomic regions, transcripts, and products section above. |
||
| 791 | |||
| 792 | Genomic |
||
| 793 | NG_012772.3 RefSeqGene |
||
| 794 | Range 5000..89192 |
||
| 795 | Download GenBank FASTA Sequence Viewer (Graphics) |
||
| 796 | |||
| 797 | |||
| 798 | |||
| 799 | mRNA and Protein(s) |
||
| 800 | |||
| 801 | NM_000059.4 → NP_000050.3 REVIEWEDbreast cancer type 2 susceptibility protein isoform 1 |
||
| 802 | Source sequence(s): AL137247, AL445212 |
||
| 803 | Consensus CDS: CCDS9344.1 |
||
| 804 | UniProtKB/TrEMBL: A0A7P0T9D7 |
||
| 805 | UniProtKB/Swiss-Prot: Q5TBJ7 |
||
| 806 | |||
| 807 | Related Ensembl: ENSP00000369497.3, ENST00000380152.8 |
||
| 808 | Conserved Domains (5)summary |
||
| 809 | cd04494: |
||
| 810 | Location:2804 - 3054 |
||
| 811 | BRCA2DBD_OB2; A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino aci... |
||
| 812 | pfam00634: |
||
| 813 | Location:1213 - 1243 |
||
| 814 | BRCA2; BRCA2 repeat |
||
| 815 | pfam09103: |
||
| 816 | Location:2670 - 2793 |
||
| 817 | BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 |
||
| 818 | pfam09104: |
||
| 819 | Location:3054 - 3186 |
||
| 820 | BRCA-2_OB3; BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 |
||
| 821 | pfam09169: |
||
| 822 | Location:2481 - 2667 |
||
| 823 | BRCA-2_helical; BRCA2, helical |
||
| 824 | |||
| 825 | NM_001406719.1 → NP_001393648.1 REVIEWEDbreast cancer type 2 susceptibility protein isoform 3 |
||
| 826 | Source sequence(s): AL137247, AL445212 |
||
| 827 | |||
| 828 | NM_001406720.1 → NP_001393649.1 REVIEWEDbreast cancer type 2 susceptibility protein isoform 2 |
||
| 829 | Source sequence(s): AL137247, AL445212 |
||
| 830 | |||
| 831 | NM_001406721.1 → NP_001393650.1 REVIEWEDbreast cancer type 2 susceptibility protein isoform 4 |
||
| 832 | Source sequence(s): AL137247, AL445212 |
||
| 833 | |||
| 834 | NM_001406722.1 → NP_001393651.1 REVIEWEDbreast cancer type 2 susceptibility protein isoform 5 |
||
| 835 | Source sequence(s): AL137247, AL445212 |
||
| 836 | |||
| 837 | RNA |
||
| 838 | |||
| 839 | NR_176251.1 RNA Sequence |
||
| 840 | Source sequence(s): AL137247, AL445212 |
||
| 841 | |||
| 842 | RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03 |
||
| 843 | The following sections contain reference sequences that belong to a specific genome build. |
||
| 844 | This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which |
||
| 845 | this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both |
||
| 846 | reference and alternate assemblies. Model RNAs and proteins are also reported here. |
||
| 847 | |||
| 848 | Reference GRCh38.p14 Primary Assembly |
||
| 849 | |||
| 850 | Genomic |
||
| 851 | NC_000013.11 Reference GRCh38.p14 Primary Assembly |
||
| 852 | Range 32315507..32400267 |
||
| 853 | Download GenBank FASTA Sequence Viewer (Graphics) |
||
| 854 | |||
| 855 | Alternate T2T-CHM13v2.0 |
||
| 856 | |||
| 857 | Genomic |
||
| 858 | NC_060937.1 Alternate T2T-CHM13v2.0 |
||
| 859 | Range 31532752..31617509 |
||
| 860 | Download GenBank FASTA Sequence Viewer (Graphics) |
||
| 861 | |||
| 862 | |||
| 863 | |||
| 864 | RELATED SEQUENCES |
||
| 865 | ------------------------------------------------------------------------------------------------- |
||
| 866 | |||
| 867 | Nucleotide Protein |
||
| 868 | ------------------------------------------------------------------------------------------------- |
||
| 869 | genomic AF288938.2 None |
||
| 870 | genomic AF309413.1 AAG46030.1 |
||
| 871 | genomic AF317283.1 None |
||
| 872 | genomic AF348515.1 AAK29432.1 |
||
| 873 | genomic AF489725.1 AAN61409.1 |
||
| 874 | genomic AF489726.1 AAN61410.1 |
||
| 875 | genomic AF489727.1 AAN61411.1 |
||
| 876 | genomic AF489728.1 AAN61412.1 |
||
| 877 | genomic AF489729.1 AAN61413.1 |
||
| 878 | genomic AF489730.1 AAN61414.1 |
||
| 879 | genomic AF489731.1 AAN61415.1 |
||
| 880 | genomic AF489732.1 AAN61416.1 |
||
| 881 | genomic AF489733.1 AAN61417.1 |
||
| 882 | genomic AF489734.1 AAN61418.1 |
||
| 883 | genomic AF489735.1 AAN61419.1 |
||
| 884 | genomic AF489736.1 AAN61420.1 |
||
| 885 | genomic AF489737.1 AAN61421.1 |
||
| 886 | genomic AF489738.1 AAN61422.1 |
||
| 887 | genomic AF507079.1 AAN61426.1 |
||
| 888 | genomic AF507080.1 AAN61427.1 |
||
| 889 | genomic AF507081.1 AAN61428.1 |
||
| 890 | genomic AF507082.1 AAN61429.1 |
||
| 891 | genomic AF507083.1 AAN61430.1 |
||
| 892 | genomic AF507084.1 AAN61431.1 |
||
| 893 | genomic AF507085.1 AAN61432.1 |
||
| 894 | genomic AF507086.1 AAN61433.1 |
||
| 895 | genomic AF507087.1 AAN61434.1 |
||
| 896 | genomic AF507088.1 AAN61435.1 |
||
| 897 | genomic AF507089.1 AAN61436.1 |
||
| 898 | genomic AF507090.1 AAN61437.1 |
||
| 899 | genomic AL137247.14(100..1899) None |
||
| 900 | genomic AL445212.9(83668..166657) None |
||
| 901 | genomic AY008850.1 AAG32681.1 |
||
| 902 | genomic AY008851.1 AAG32682.1 |
||
| 903 | genomic AY151039.1 AAN28944.1 |
||
| 904 | genomic AY436640.1 AAQ97181.1 |
||
| 905 | genomic CH471075.1 EAX08499.1 |
||
| 906 | EAX08500 |
||
| 907 | EAX08501 |
||
| 908 | genomic CP068265.2(31532753..31617510) None |
||
| 909 | genomic DQ115319.1 AAZ22546.1 |
||
| 910 | genomic DQ889340.1 ABJ90481.1 |
||
| 911 | genomic EU625579.1 ACD01217.1 |
||
| 912 | genomic HM763690.1 None |
||
| 913 | genomic HQ221557.1 None |
||
| 914 | genomic HQ221558.1 None |
||
| 915 | genomic KJ625180.1 AIC83538.1 |
||
| 916 | genomic KJ625181.1 AIC83560.1 |
||
| 917 | genomic KJ625182.1 AIC83561.1 |
||
| 918 | genomic KJ625183.1 AIC83562.1 |
||
| 919 | genomic KJ625184.1 AIC83563.1 |
||
| 920 | genomic KJ625185.1 AIC83564.1 |
||
| 921 | genomic KJ625186.1 AIC83565.1 |
||
| 922 | genomic KJ625187.1 AIC83566.1 |
||
| 923 | genomic KJ625188.1 AIC83567.1 |
||
| 924 | genomic KJ625189.1 AIC83568.1 |
||
| 925 | genomic KJ625190.1 AIC83569.1 |
||
| 926 | genomic KJ625191.1 AIC83570.1 |
||
| 927 | genomic KJ625192.1 AIC83543.1 |
||
| 928 | genomic KJ625193.1 AIC83536.1 |
||
| 929 | genomic KJ625194.1 AIC83537.1 |
||
| 930 | genomic KJ625195.1 AIC83534.1 |
||
| 931 | genomic KJ625196.1 AIC83535.1 |
||
| 932 | genomic KJ625197.1 AIC83532.1 |
||
| 933 | genomic KJ625198.1 AIC83533.1 |
||
| 934 | genomic KJ625199.1 AIC83531.1 |
||
| 935 | genomic KJ625200.1 AIC83529.1 |
||
| 936 | genomic KJ625201.1 AIC83530.1 |
||
| 937 | genomic KJ625202.1 AIC83583.1 |
||
| 938 | genomic KJ625203.1 AIC83584.1 |
||
| 939 | AIC83585 |
||
| 940 | AIC83586 |
||
| 941 | genomic KJ625204.1 AIC83587.1 |
||
| 942 | genomic KJ625205.1 AIC83588.1 |
||
| 943 | genomic KM464556.1 AIY60806.1 |
||
| 944 | genomic KP255404.1 AKE50582.1 |
||
| 945 | genomic KP255405.1 AKE50583.1 |
||
| 946 | genomic KP255406.1 AKE50584.1 |
||
| 947 | genomic KP255407.1 AKE50585.1 |
||
| 948 | genomic KP255408.1 AKE50586.1 |
||
| 949 | genomic KP255409.1 AKE50587.1 |
||
| 950 | genomic KP255410.1 AKE50588.1 |
||
| 951 | genomic KP255411.1 AKE50589.1 |
||
| 952 | genomic KP255412.1 AKE50590.1 |
||
| 953 | genomic KP255413.1 AKE50591.1 |
||
| 954 | genomic KP255414.1 AKE50592.1 |
||
| 955 | genomic KP255415.1 AKE50593.1 |
||
| 956 | genomic KP255416.1 AKE50594.1 |
||
| 957 | genomic KP255417.1 AKE50595.1 |
||
| 958 | genomic KT901805.2 ALQ44025.1 |
||
| 959 | genomic KT901806.1 ALQ44026.1 |
||
| 960 | genomic KT901807.2 ALQ44027.1 |
||
| 961 | genomic KT901808.2 ALQ44028.1 |
||
| 962 | genomic KT901809.1 ALQ44029.1 |
||
| 963 | genomic KT901810.2 ALQ44030.1 |
||
| 964 | genomic KT901812.2 ALQ44032.1 |
||
| 965 | genomic KT901813.2 ALQ44033.1 |
||
| 966 | genomic KT901814.1 ALQ44034.1 |
||
| 967 | genomic KX492888.1 None |
||
| 968 | genomic KX492889.1 None |
||
| 969 | genomic KY302339.1 AQQ13115.1 |
||
| 970 | genomic LC331708.1 None |
||
| 971 | genomic LC331709.1 None |
||
| 972 | genomic LC331710.1 None |
||
| 973 | genomic LC331907.1 None |
||
| 974 | genomic LC331908.1 None |
||
| 975 | genomic LC331909.1 None |
||
| 976 | genomic LC331910.1 None |
||
| 977 | genomic LC331911.1 None |
||
| 978 | genomic LC331912.1 None |
||
| 979 | genomic MF098560.1 AWJ64385.1 |
||
| 980 | genomic MF098561.1 AWJ64386.1 |
||
| 981 | genomic MF098562.1 AWJ64387.1 |
||
| 982 | genomic MF431605.1 ASV63591.1 |
||
| 983 | genomic MF769700.1 ASW23221.1 |
||
| 984 | genomic MF769701.1 ASW23222.1 |
||
| 985 | genomic MF769702.1 ASW23223.1 |
||
| 986 | genomic MF769703.1 ASW23224.1 |
||
| 987 | genomic MF769704.1 ASW23225.1 |
||
| 988 | genomic MF769705.1 ASW23226.1 |
||
| 989 | genomic MF769706.1 ASW23227.1 |
||
| 990 | genomic MF769707.1 ASW23228.1 |
||
| 991 | genomic MF769708.1 ASW23229.1 |
||
| 992 | genomic MF769709.1 ASW23230.1 |
||
| 993 | genomic MF769710.1 ASW23231.1 |
||
| 994 | genomic MF769711.1 ASW23232.1 |
||
| 995 | genomic MG494343.1 AYD59811.1 |
||
| 996 | genomic MG494344.1 AYD59812.1 |
||
| 997 | genomic MG494345.1 AYD59813.1 |
||
| 998 | AYD59814 |
||
| 999 | genomic MG494346.1 AYD59815.1 |
||
| 1000 | genomic MG494349.1 None |
||
| 1001 | genomic MG494350.1 None |
||
| 1002 | genomic MG494351.1 None |
||
| 1003 | genomic MH068859.1 None |
||
| 1004 | genomic MN698972.1 QNJ44865.1 |
||
| 1005 | genomic MN698973.1 QNJ44866.1 |
||
| 1006 | genomic MT731961.1 UAM96193.1 |
||
| 1007 | genomic MT793119.1 QSV17868.1 |
||
| 1008 | genomic MT799786.1 QSV17869.1 |
||
| 1009 | genomic MT901679.1 QUD18340.1 |
||
| 1010 | genomic MT901680.1 QUD18341.1 |
||
| 1011 | genomic MT901681.1 QUD18342.1 |
||
| 1012 | genomic MT901682.1 QUD18343.1 |
||
| 1013 | genomic MT901683.1 QUD18344.1 |
||
| 1014 | genomic MT901684.1 QUD18345.1 |
||
| 1015 | genomic MT901685.1 QUD18346.1 |
||
| 1016 | genomic MW048525.1 UGU37860.1 |
||
| 1017 | genomic MW600293.1 QVP25877.1 |
||
| 1018 | genomic MW928852.1 QVP25878.1 |
||
| 1019 | genomic MW928853.1 QVP25879.1 |
||
| 1020 | genomic MW928854.1 QVP25880.1 |
||
| 1021 | genomic MW928855.1 QVP25881.1 |
||
| 1022 | genomic MW928856.1 QVP25882.1 |
||
| 1023 | genomic MW928857.1 QVP25883.1 |
||
| 1024 | genomic MW928858.1 QVP25884.1 |
||
| 1025 | genomic MW928859.1 QVP25885.1 |
||
| 1026 | genomic MW928860.1 QVP25886.1 |
||
| 1027 | genomic MW928861.1 QVP25887.1 |
||
| 1028 | genomic MW928862.1 QVP25888.1 |
||
| 1029 | genomic MW928863.1 QVP25889.1 |
||
| 1030 | genomic MW928864.1 QVP25890.1 |
||
| 1031 | genomic MW928865.1 QVP25891.1 |
||
| 1032 | genomic MW928866.1 QVP25892.1 |
||
| 1033 | genomic MW928867.1 QVP25893.1 |
||
| 1034 | genomic MW928868.1 QVP25894.1 |
||
| 1035 | genomic MW928869.1 QVP25895.1 |
||
| 1036 | genomic MW928870.1 QVP25896.1 |
||
| 1037 | genomic MW928871.1 QVP25897.1 |
||
| 1038 | genomic MW928872.1 QVP25898.1 |
||
| 1039 | genomic MW928873.1 QVP25899.1 |
||
| 1040 | genomic MW928874.1 QVP25900.1 |
||
| 1041 | genomic MW928875.1 QVP25901.1 |
||
| 1042 | genomic MW928876.1 QVP25902.1 |
||
| 1043 | genomic MW928877.1 QVP25903.1 |
||
| 1044 | genomic MW928878.1 QVP25904.1 |
||
| 1045 | genomic MW928879.1 QVP25905.1 |
||
| 1046 | genomic MW928880.1 QVP25906.1 |
||
| 1047 | genomic MW928881.1 QVP25907.1 |
||
| 1048 | genomic MW928882.1 QVP25908.1 |
||
| 1049 | genomic MW928883.1 QVP25909.1 |
||
| 1050 | genomic MW928884.1 QVP25910.1 |
||
| 1051 | genomic MW928885.1 QVP25911.1 |
||
| 1052 | genomic MW928886.1 QVP25912.1 |
||
| 1053 | genomic MW928887.1 QVP25913.1 |
||
| 1054 | genomic MZ027671.1 QVP25914.1 |
||
| 1055 | genomic MZ027672.1 QVP25915.1 |
||
| 1056 | genomic MZ029095.1 UWU44243.1 |
||
| 1057 | genomic MZ029096.1 UWU44244.1 |
||
| 1058 | genomic MZ029097.1 UWU44245.1 |
||
| 1059 | genomic MZ029098.1 UWU44246.1 |
||
| 1060 | genomic MZ029099.1 UWU44247.1 |
||
| 1061 | genomic MZ029100.1 UWU44248.1 |
||
| 1062 | genomic MZ029101.1 UWU44249.1 |
||
| 1063 | genomic MZ029102.1 UWU44250.1 |
||
| 1064 | genomic MZ029103.1 UWU44251.1 |
||
| 1065 | genomic MZ029104.1 UWU44252.1 |
||
| 1066 | genomic MZ029105.1 UWU44253.1 |
||
| 1067 | genomic MZ029106.1 UWU44254.1 |
||
| 1068 | genomic MZ029107.1 UWU44255.1 |
||
| 1069 | genomic MZ029108.1 UWU44256.1 |
||
| 1070 | genomic MZ029109.1 UWU44257.1 |
||
| 1071 | genomic MZ054388.1 QVP25916.1 |
||
| 1072 | genomic MZ054389.1 QVP25917.1 |
||
| 1073 | genomic MZ567236.1 UIW38570.1 |
||
| 1074 | genomic MZ567237.1 UIW38571.1 |
||
| 1075 | genomic MZ567238.1 UIW38572.1 |
||
| 1076 | genomic MZ567239.1 UIW38573.1 |
||
| 1077 | genomic MZ803008.1 UGY71104.1 |
||
| 1078 | genomic MZ803009.1 UGY71105.1 |
||
| 1079 | genomic OL512957.1 None |
||
| 1080 | genomic OL538159.1 None |
||
| 1081 | genomic OL546650.1 None |
||
| 1082 | genomic OM350328.1 UOG94978.1 |
||
| 1083 | genomic OM350329.1 UOG94979.1 |
||
| 1084 | genomic OM350330.1 UOG94980.1 |
||
| 1085 | genomic OM350331.1 UOG94981.1 |
||
| 1086 | genomic OM350332.1 UOG94982.1 |
||
| 1087 | genomic OM350333.1 UOG94983.1 |
||
| 1088 | genomic OM350334.1 UOG94984.1 |
||
| 1089 | genomic OM650684.1 WAK86307.1 |
||
| 1090 | genomic OM650685.1 WAK86308.1 |
||
| 1091 | genomic OM650687.1 WAK86310.1 |
||
| 1092 | genomic X95151.1(269..456) None |
||
| 1093 | genomic X95152.1 CAA64484.1 |
||
| 1094 | genomic X95153.1(501..749) None |
||
| 1095 | genomic X95154.1(166..274) None |
||
| 1096 | genomic X95155.1(501..550) None |
||
| 1097 | genomic X95156.1(501..541) None |
||
| 1098 | genomic X95157.1(501..615) None |
||
| 1099 | genomic X95158.1(501..550) None |
||
| 1100 | genomic X95159.1(501..612) None |
||
| 1101 | genomic X95160.1(431..1546) None |
||
| 1102 | genomic X95161.1 None |
||
| 1103 | genomic X95163.1(481..550) None |
||
| 1104 | genomic X95164.1(481..908) None |
||
| 1105 | genomic X95165.1(77..242) None |
||
| 1106 | genomic X95166.1(481..684) None |
||
| 1107 | genomic X95167.1(501..671) None |
||
| 1108 | genomic X95168.1(501..855) None |
||
| 1109 | genomic X95169.1(500..655) None |
||
| 1110 | genomic X95170.1(501..645) None |
||
| 1111 | genomic X95171.1(219..340) None |
||
| 1112 | genomic X95172.1(501..699) None |
||
| 1113 | genomic X95173.1(501..664) None |
||
| 1114 | genomic X95174.1(501..639) None |
||
| 1115 | genomic X95175.1(501..745) None |
||
| 1116 | genomic X95176.1(501..647) None |
||
| 1117 | genomic X95177.1(310..1757) None |
||
| 1118 | genomic Z73359.1 CAA97728.1 |
||
| 1119 | genomic Z74739.1 CAA98995.2 |
||
| 1120 | mRNA BC026160.1 None |
||
| 1121 | mRNA BC047568.1 None |
||
| 1122 | mRNA DQ897648.1 ABI74674.1 |
||
| 1123 | mRNA JX480468.1 AFU88810.1 |
||
| 1124 | mRNA JX480469.1 AFU88811.1 |
||
| 1125 | mRNA JX480470.1 AFU88812.1 |
||
| 1126 | mRNA JX480471.1 AFU88813.1 |
||
| 1127 | mRNA JX480472.1 AFU88814.1 |
||
| 1128 | mRNA JX480473.1 AFU88815.1 |
||
| 1129 | mRNA JX480474.1 AFU88816.1 |
||
| 1130 | mRNA JX480475.1 AFU88817.1 |
||
| 1131 | mRNA JX480476.1 AFU88818.1 |
||
| 1132 | mRNA JX480477.1 AFU88819.1 |
||
| 1133 | mRNA JX480478.1 AFU88820.1 |
||
| 1134 | mRNA KP272107.1 AKG51649.1 |
||
| 1135 | mRNA KP272108.1 AKG51650.1 |
||
| 1136 | mRNA LC547969.1 None |
||
| 1137 | mRNA MG494302.1 AYD59769.1 |
||
| 1138 | mRNA MG494303.1 AYD59770.1 |
||
| 1139 | mRNA MG494304.1 AYD59771.1 |
||
| 1140 | mRNA MG494305.1 AYD59772.1 |
||
| 1141 | mRNA MG494306.1 AYD59773.1 |
||
| 1142 | mRNA MG494307.1 AYD59774.1 |
||
| 1143 | mRNA MG494308.1 AYD59775.1 |
||
| 1144 | mRNA MG494309.1 AYD59776.1 |
||
| 1145 | mRNA MG494310.1 AYD59777.1 |
||
| 1146 | mRNA MG494311.1 AYD59778.1 |
||
| 1147 | mRNA MG494312.1 AYD59779.1 |
||
| 1148 | mRNA MG494313.1 AYD59780.1 |
||
| 1149 | mRNA MG494314.1 AYD59781.1 |
||
| 1150 | mRNA MG494315.1 AYD59782.1 |
||
| 1151 | mRNA MG494316.1 AYD59783.1 |
||
| 1152 | mRNA MG494317.1 AYD59784.1 |
||
| 1153 | mRNA MG494318.1 AYD59785.1 |
||
| 1154 | mRNA MG494319.1 AYD59786.1 |
||
| 1155 | mRNA MG494320.1 AYD59787.1 |
||
| 1156 | mRNA MG494321.1 AYD59788.1 |
||
| 1157 | mRNA MG494322.1 AYD59789.1 |
||
| 1158 | mRNA MG494323.1 AYD59790.1 |
||
| 1159 | mRNA MG494324.1 AYD59791.1 |
||
| 1160 | mRNA MG494325.1 AYD59792.1 |
||
| 1161 | mRNA MG494326.1 AYD59793.1 |
||
| 1162 | mRNA MG494327.1 AYD59794.1 |
||
| 1163 | mRNA MG494328.1 AYD59795.1 |
||
| 1164 | mRNA MG494329.1 AYD59796.1 |
||
| 1165 | mRNA MG494330.1 AYD59797.1 |
||
| 1166 | mRNA MG494331.1 AYD59798.1 |
||
| 1167 | mRNA MG494332.1 AYD59799.1 |
||
| 1168 | mRNA MG494333.1 AYD59800.1 |
||
| 1169 | mRNA MG494334.1 AYD59801.1 |
||
| 1170 | mRNA MG494335.1 AYD59802.1 |
||
| 1171 | mRNA MG494336.1 AYD59803.1 |
||
| 1172 | mRNA MH068861.1 None |
||
| 1173 | mRNA MH068862.1 None |
||
| 1174 | mRNA MH068863.1 None |
||
| 1175 | mRNA MH068864.1 None |
||
| 1176 | mRNA MH068865.1 None |
||
| 1177 | mRNA MK028702.1 QCL11115.1 |
||
| 1178 | mRNA MK028703.1 QCL11116.1 |
||
| 1179 | mRNA MK028704.1 QCL11117.1 |
||
| 1180 | mRNA MK028705.1 QCL11118.1 |
||
| 1181 | mRNA MK848287.1 QGJ03645.1 |
||
| 1182 | mRNA MK848288.1 QGJ03646.1 |
||
| 1183 | mRNA MK848289.1 QGJ03647.1 |
||
| 1184 | mRNA MK848290.1 QGJ03648.1 |
||
| 1185 | mRNA MN264277.1 QIM56776.1 |
||
| 1186 | mRNA MN264278.1 QIM56777.1 |
||
| 1187 | mRNA MN780897.1 QNO58539.1 |
||
| 1188 | mRNA MN780898.1 QNO58540.1 |
||
| 1189 | mRNA MT024694.1 QNC49812.1 |
||
| 1190 | mRNA MT313307.1 QTZ96721.1 |
||
| 1191 | mRNA MT731957.1 UAM96189.1 |
||
| 1192 | mRNA MT731958.1 UAM96190.1 |
||
| 1193 | mRNA MW117159.1 UGU37864.1 |
||
| 1194 | mRNA MW117160.1 UGU37865.1 |
||
| 1195 | mRNA MW703446.1 UIW38032.1 |
||
| 1196 | mRNA MW703447.1 UIW38033.1 |
||
| 1197 | mRNA MW703448.1 UIW38034.1 |
||
| 1198 | mRNA MZ047302.1 UIW38053.1 |
||
| 1199 | mRNA OK018166.1 UGU37889.1 |
||
| 1200 | mRNA OK018167.1 UGU37890.1 |
||
| 1201 | mRNA OK018168.1 UGU37891.1 |
||
| 1202 | mRNA OK018169.1 UGU37892.1 |
||
| 1203 | mRNA OK018170.1 UGU37893.1 |
||
| 1204 | mRNA OK018171.1 UGU37894.1 |
||
| 1205 | mRNA OK018172.1 UGU37895.1 |
||
| 1206 | mRNA OK018173.1 UGU37896.1 |
||
| 1207 | mRNA OL856010.1 UIW38575.1 |
||
| 1208 | mRNA OL856011.1 UIW38576.1 |
||
| 1209 | mRNA OL856012.1 UIW38577.1 |
||
| 1210 | mRNA OL856013.1 UIW38578.1 |
||
| 1211 | mRNA OL856014.1 UIW38579.1 |
||
| 1212 | mRNA U43746.1 AAB07223.1 |
||
| 1213 | |||
| 1214 | Protein Accession Links |
||
| 1215 | ------------------------------------------------------------------------------------------------- |
||
| 1216 | P51587.4 GenPept(/protein/2203400801) UniProtKB/Swiss-Prot:P51587 |
||
| 1217 | |||
| 1218 | GENE LINKOUT |
||
| 1219 | ------------------------------------------------------------------------------------------------- |
||
| 1220 | The following LinkOut(www.ncbi.nlm.nih.gov/projects/linkout/index.html) resources |
||
| 1221 | are supplied by external providers. These providers are responsible for |
||
| 1222 | maintaining the links. |
||
| 1223 | |||
| 1224 | Chemical Information |
||
| 1225 | (Free resource) (free) Interologous Interaction Database |
||
| 1226 | Interologous Interaction Database |
||
| 1227 | (Order form) MilliporeSigma |
||
| 1228 | Brca2 productsBrca2 products |
||
| 1229 | (Order form) Novus Biologicals |
||
| 1230 | Primary AntibodiesPrimary AntibodiesRNAiRNAi |
||
| 1231 | |||
| 1232 | Medical |
||
| 1233 | (Free resource) (free) MedlinePlus Health Information |
||
| 1234 | BRCA2 geneBRCA2 gene |
||
| 1235 | |||
| 1236 | Molecular Biology Databases |
||
| 1237 | (Free resource) (free) Bgee database |
||
| 1238 | BRCA2 gene expressionBRCA2 gene expression |
||
| 1239 | (Free resource) (free) BioGPS |
||
| 1240 | BioGPS |
||
| 1241 | (Free resource) (free) BioGRID Open Repository of CRISPR Screens (ORCS) |
||
| 1242 | BioGRID CRISPR Screen Phenotypes (342 hits/1176 screens)BioGRID CRISPR Screen Phenotypes (342 hits/1176 screens) |
||
| 1243 | (Free resource) (free) CREB Target Gene Database |
||
| 1244 | CREB Target Gene Database |
||
| 1245 | (Free resource) (Free registration required) (free) Creative Biogene |
||
| 1246 | breast cancer 2, early onsetbreast cancer 2, early onset |
||
| 1247 | (Free resource) (free) Domain Mapping of Disease Mutations |
||
| 1248 | BRCA2BRCA2 |
||
| 1249 | (Free resource) (free) Eukaryotic Promoter Database |
||
| 1250 | BRCA2_1BRCA2_1 |
||
| 1251 | (Free resource) (free) GenAge Database of Aging Related Genes |
||
| 1252 | GenAge Database of Aging Related Genes |
||
| 1253 | (Order form) GenScript latest version of gene cDNA ORF Clone |
||
| 1254 | GenScript latest version of gene cDNA ORF Clone |
||
| 1255 | (Free resource) (free) GeneNetwork |
||
| 1256 | Records for gene expression in HumanRecords for gene expression in Human |
||
| 1257 | (Free resource) (free) Genevisible |
||
| 1258 | BRCA2BRCA2 |
||
| 1259 | (Free resource) (free) GlyGen glycoinformatics resource |
||
| 1260 | GlyGen glycoinformatics resource |
||
| 1261 | (Free resource) (Free registration required) (free) Human Gene Mutation Database |
||
| 1262 | Human Gene Mutation Database |
||
| 1263 | (Free resource) (free) Human eFP Browser |
||
| 1264 | Human eFP BrowserHuman eFP BrowserHuman eFP Browser |
||
| 1265 | Ingenuity Pathways Analysis |
||
| 1266 | Ingenuity Pathways Analysis |
||
| 1267 | (Free resource) (free) InnateDB |
||
| 1268 | InnateDB |
||
| 1269 | (Free resource) (free) InterMine |
||
| 1270 | InterMine |
||
| 1271 | (Free resource) (free) Kyoto Encyclopedia of Genes and Genomes |
||
| 1272 | Kyoto Encyclopedia of Genes and Genomes |
||
| 1273 | (Free resource) (free) LSDB from Gene |
||
| 1274 | BRCA2 @ ZAC-GGMBRCA2 @ ZAC-GGMBreast Cancer Information Core (BIC)Breast Cancer Information Core (BIC)BRCA2 homepage - LOVDBRCA2 homepage - LOVD |
||
| 1275 | (Free resource) (free) OMA Browser: Orthologous MAtrix |
||
| 1276 | OMA Browser: Orthologous MAtrixOMA Browser: Orthologous MAtrix |
||
| 1277 | (Free resource) (free) OrthoDB catalog of orthologs |
||
| 1278 | OrthologsOrthologs |
||
| 1279 | (Free resource) (free) Pharmacogenomics Knowledge Base |
||
| 1280 | Annotated Pharmacogenomic Information for BRCA2 [PharmGKB]Annotated Pharmacogenomic Information for BRCA2 [PharmGKB] |
||
| 1281 | (Free resource) (free) PhosphoSitePlus |
||
| 1282 | PhosphoSitePlus® - comprehensive post-translational modification resourcePhosphoSitePlus® - comprehensive post-translational modification resource |
||
| 1283 | (Free resource) (free) Protein Ontology Consortium |
||
| 1284 | Protein Ontology Consortium |
||
| 1285 | (Free resource) (free) The Gene Wiki |
||
| 1286 | The Gene Wiki |
||
| 1287 | (Free resource) (free) The Weizmann Institute of Science GeneCards and MalaCards databases |
||
| 1288 | GeneCard for BRCA2GeneCard for BRCA2 |
||
| 1289 | (Free resource) (free) Vertebrate Genome Annotation (VEGA) database |
||
| 1290 | Vertebrate Genome Annotation (VEGA) database |
||
| 1291 | (Free resource) (free) iRefWeb - iRefIndex release 9.0 - Consolidated Interactome |
||
| 1292 | iRefWeb - iRefIndex release 9.0 - Consolidated Interactome |
||
| 1293 | |||
| 1294 | Research Materials |
||
| 1295 | (Order form) Addgene Non-profit plasmid repository |
||
| 1296 | Get Plasmids - AddgeneGet Plasmids - Addgene |
||
| 1297 | ExactAntigen/Labome |
||
| 1298 | reagentsreagentsreagent reviewreagent review |
||
| 1299 | (Order form) GeneCopoeia Inc. |
||
| 1300 | Order full-length ORF cloneOrder full-length ORF cloneOrder TALEN/CRISPR clonesOrder TALEN/CRISPR clones |
||
| 1301 | LifeSpan BioSciences, Inc. |
||
| 1302 | LSBio BRCA2 ProteinsLSBio BRCA2 Proteins |
||
| 1303 | (Order form) Sino Biological Inc. |
||
| 1304 | Human BRCA2 partial Gene cDNA Clone / ORF CloneHuman BRCA2 partial Gene cDNA Clone / ORF Clone |
||
| 1305 | |||
| 1306 | Tools |
||
| 1307 | (Free resource) (free) GeneMANIA |
||
| 1308 | GeneMANIA |