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--- a +++ b/GeneID_5728.txt @@ -0,0 +1,2349 @@ +PTEN phosphatase and tensin homolog[Homo sapiens] +Gene ID: 5728, updated on 1-May-2023 + + +SUMMARY +------------------------------------------------------------------------------------------------- + +Official Symbol: PTEN (provided by HGNC) +Official full name: phosphatase and tensin homolog (provided by HGNC) +Primary source: HGNC:HGNC:9588 +See related: Ensembl:ENSG00000171862; MIM:601728; AllianceGenome:HGNC:9588 +Gene type: protein coding +RefSeq status: REVIEWED +Organism: Homo sapiens + +Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; +Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo + +Also known as: BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta + +Summary: This gene was identified as a tumor suppressor that is mutated in a large number +of cancers at high frequency. The protein encoded by this gene is a +phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like +domain as well as a catalytic domain similar to that of the dual specificity +protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, +this protein preferentially dephosphorylates phosphoinositide substrates. It +negatively regulates intracellular levels of +phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor +suppressor by negatively regulating AKT/PKB signaling pathway. The use of a +non-canonical (CUG) upstream initiation site produces a longer isoform that +initiates translation with a leucine, and is thought to be preferentially +associated with the mitochondrial inner membrane. This longer isoform may help +regulate energy metabolism in the mitochondria. A pseudogene of this gene is +found on chromosome 9. Alternative splicing and the use of multiple translation +start codons results in multiple transcript variants encoding different isoforms. +[provided by RefSeq, Feb 2015] + +Annotation information: Annotation category: suggests misassembly + +Orthologsall (/gene/?Term=ortholog_gene_5728[group]), mouse (https://www.ncbi.nlm.nih.gov/gene/19211) + +GENOMIC CONTEXT +------------------------------------------------------------------------------------------------- + + +Location: 10q23.31 + +Annotation release Status Assembly Chromosome Location +------------------------------------------------------------------------------------------------- +RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (87863625..87971930) +RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (88747528..88855830) +105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89623382..89731687) +Exont count: 10 + + +BIBLIOGRAPHY +------------------------------------------------------------------------------------------------- + + +Related Articles in PubMed + +1. Longitudinal Analysis of Cancer Risk in Children and Adults With Germline PTEN +Variants. Yehia L, . JAMA Netw Open, 2023 Apr 3, PMID 37093598., Free PMC Article(s): PMC10126871 +2. Overexpression of the PTEN Gene in Myocardial Tissues of Coronary Bypass Surgery +Patients. Tahtasakal R, . Arq Bras Cardiol, 2023, PMID 37042855. +3. Pan-cancer genomic analysis shows hemizygous PTEN loss tumors are associated with +immune evasion and poor outcome. Vidotto T, . Sci Rep, 2023 Mar 28, PMID +36977733., Free PMC Article(s): PMC10050165 +4. miR-19-3p Targets PTEN to Regulate Cervical Cancer Cell Proliferation, Invasion, +and Autophagy. Wang W, . Genet Res (Camb), 2023, PMID 36908850., Free PMC Article(s): PMC10005872 +5. Nuclear PTEN's Functions in Suppressing Tumorigenesis: Implications for Rare +Cancers. Langdon CG. Biomolecules, 2023 Jan 30, PMID 36830628., Free PMC Article(s): PMC9953540 +6. The PTEN-associated immune prognostic signature reveals the landscape of the +tumor microenvironment in glioblastoma. Yu J, . J Neuroimmunol, 2023 Mar 15, PMID +36791582. +<pre> +PHENOTYPES +------------------------------------------------------------------------------------------------- + +Review eQTL and phenotype association data in this region using PheGenI + http://www.ncbi.nlm.nih.gov/gap/PheGenI?chr=10&from=87863624&fromto=87863624+87971929&tab=0 + +Professional guidelines +------------------------------------------------------------------------------------------------- +Professional guideline + ACMG 2013 + The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in PTEN that are pathogenic or expected to be pathogenic. + + Guideline(http://www.acmg.net/docs/ACMG_Releases_Highly-Anticipated_Recommendations_on_Incidental_Findings_in_Clinical_Exome_and_Genome_Sequencing.pdf) + PubMed(/pubmed/23788249) +Associated conditions +------------------------------------------------------------------------------------------------- +Description Tests +------------------------------------------------------------------------------------------------- + +Cowden syndrome 1 + MedGen: CN072330 OMIM: 158350 GeneReviews: PTEN Hamartoma Tumor Syndrome +Familial meningioma + MedGen: C3551915 OMIM: 607174 GeneReviews: MN1 C-Terminal Truncation Syndrome +Genome-wide association study of chronic periodontitis in a general German population. + GeneReviews: <span>Not available</span> +Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. + GeneReviews: <span>Not available</span> +Glioma susceptibility 2 + MedGen: C2751642 OMIM: 613028 GeneReviews: <span>Not available</span> +Macrocephaly-autism syndrome + MedGen: C1854416 OMIM: 605309 GeneReviews: <span>Not available</span> +Malignant tumor of prostate + MedGen: C0376358 OMIM: 176807 GeneReviews: <span>Not available</span> +PTEN hamartoma tumor syndrome + MedGen: C1959582 GeneReviews: PTEN Hamartoma Tumor Syndrome + +Copy number response +------------------------------------------------------------------------------------------------- +Copy number response + Triplosensitivity + No evidence available (Last evaluated 2020-06-24) + + ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=PTEN)Haploinsufficency + Sufficient evidence for dosage pathogenicity (Last evaluated 2020-06-24) + + ClinGen Genome Curation Page(https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=PTEN) + PubMed(/pubmed/21194675,32003824)</pre> + +VARIATION +------------------------------------------------------------------------------------------------- + +See variants in ClinVar, http://130.14.22.59/sites/gene/clinvar/?term=PTEN[gene] +See studies and variants in dbVar, http://130.14.22.59/sites/gene +See Variation Viewer (GRCh37.p13), http://130.14.22.59/sites/gene/variation/view/?q=5728[geneid]&assm=GCF_000001405.25 +See Variation Viewer (GRCh38), http://130.14.22.59/sites/gene/variation/view/?q=5728[geneid]<pre/><pre> +Genotypes + See SNP Geneview Report, http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2FSNP%2Fsnp_ref.cgi%3FlocusId%3D5728 + See 1000 Genomes Browser (GCF_000001405.25), http://130.14.22.59/sites/gene/variation/tools/1000genomes/?q=5728[geneid]&assm=GCF_000001405.25</pre> + +HIV-1 INTERACTIONS +------------------------------------------------------------------------------------------------- +Replication interactions +Interaction Pubs +------------------------------------------------------------------------------------------------- +Knockdown of phosphatase and tensin homolog (PTEN) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells 19460752Protein interactions +Protein Gene Interaction Pubs +------------------------------------------------------------------------------------------------- +/protein/28876544 /gene/155971 Silencing PTEN gene by siRNA prevents HIV-1 gp120-mediated neurotoxic effects 21234828 +/protein/28872818 /gene/156110 HIV-1 Nef- and KSHV K1-induced angiogenesis is regulated by miR-718-mediated target of PTEN 25104021 +/protein/9629358 /gene/155871 HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells 23301033 +/protein/9629358 /gene/155871 Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway 21763505,19526283,17157319 +/protein/9629358 /gene/155871 HIV-1 Tat upregulates PTEN expression in Tat-infected Jurkat T cells 22422068,20862322,19050264 +/protein/9629358 /gene/155871 Inhibiting phosphatidylinositol 3-kinase by overexpressing PTEN phosphatase enhances HIV-1 Tat transactivation of the viral LTR promoter 12077252 +/protein/28876542 /gene/155030 HIV-1 MA proteins from HIV-1 infected non-Hodgkin lymphoma patients activates AKT1 and PTEN 26578780 +/protein/28876542 /gene/155030 HIV-1 p17 and its C-terminal truncated form of p17 (p17delta36) differentially regulate Akt phosphorylation by reducing and increasing phosphorylation levels of PTEN, respectively 21423810 +/protein/28876542 /gene/155030 HIV-1 p17-induced activation of PTEN is mediated by RhoA-associated kinase (ROCK) 21423810 + +Go to the HIV-1, Human Interaction Database: http://130.14.22.59/genome/viruses/retroviruses/hiv-1/interactions/ + +INTERACTION +------------------------------------------------------------------------------------------------- + +Description of Gene Interaction table + +Product Interactant Other Gene Complex Source Pubs +------------------------------------------------------------------------------------------------- + +MAGI3 interacts with PTEN/MMAC. +NP_000305.2 NP_066016.1 MAGI3 BIND PMID: 10748157 +PTEN interacts with PICT-1. +NP_000305.2 NP_056525.1 NOP53 BIND PMID: 15355975 +PTEN interacts with Rock1. +NP_000305.2 NP_005397.1 ROCK1 BIND PMID: 15793569 +P60484 P31749 AKT1 HPRD PMID: 12297295,12077256,10866658 +P60484 P03950 ANG HPRD PMID: 16169070 +P60484 P10275 AR HPRD PMID: 15205473 +caveolin-1 interacts with PTEN. +P60484 NP_001744.2 CAV1 BIND PMID: 12176037 +P60484 Q03135 CAV1 HPRD PMID: 12176037 +P60484 P05060 CHGB HPRD PMID: 16169070 +P60484 Q7L5N1 COPS6 HPRD PMID: 16169070 +P60484 P68400 CSNK2A1 HPRD PMID: 12297295 +P60484 P19784 CSNK2A2 HPRD PMID: 12297295 +P60484 Q12959 DLG1 HPRD PMID: 10646847 +P60484 P69905 HBA2 HPRD PMID: 16169070 +P60484 Q86UL8 MAGI2 HPRD PMID: 10760291 +P60484 MAGI-3 MAGI3 HPRD PMID: 10748157 +P60484 Q9Y2H9 MAST1 HPRD PMID: 15951562 +P60484 Q6P0Q8 MAST2 HPRD PMID: 15951562 +P60484 O60307 MAST3 HPRD PMID: 15951562 +P60484 Q14764 MVP HPRD PMID: 12177006 +P60484 O14745 NHERF1 HPRD PMID: 16456542 +P60484 Q15599 NHERF2 HPRD PMID: 16456542 +P60484 P62136 PPP1CA HPRD PMID: 17274640 +P60484 P49023 PXN HPRD PMID: 11857088 +P60484 Q15831 STK11 HPRD PMID: 15987703 +P60484 P04637 TP53 HPRD PMID: 12620407 +P60484 P63279 UBE2I HPRD PMID: 12620973 +P60484 P68036 UBE2L3 HPRD PMID: 12620973 +P60484 Q9BVJ6 UTP14A HPRD PMID: 16169070 +Two-hybrid +BioGRID:111700 BioGRID:114984 AATK BioGRID PMID: 28065597 +Reconstituted Complex +BioGRID:111700 BioGRID:115372 ABCF2 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:106549 ACACA BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:106550 ACACB BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:117073 ACAP2 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:106556 ACAT1 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:106568 ACP1 BioGRID PMID: 29117568,28675297 +Reconstituted Complex +BioGRID:111700 BioGRID:106601 ACTL6A BioGRID PMID: 31685992 +Positive Genetic +BioGRID:111700 BioGRID:106614 ADA BioGRID PMID: 28319113 +Reconstituted Complex +BioGRID:111700 BioGRID:106617 ADAR BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:127907 ADGRF3 BioGRID PMID: 15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:116139 AFG3L2 BioGRID PMID: 30631154 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:106682 AFP BioGRID PMID: 31811908 +Affinity Capture-MS +BioGRID:111700 BioGRID:115987 AHCYL1 BioGRID PMID: 28675297 +Reconstituted Complex +BioGRID:111700 BioGRID:114958 AKAP12 BioGRID PMID: 26561776 +Affinity Capture-Western; FRET +BioGRID:111700 BioGRID:106710 AKT1 BioGRID PMID: 28205554,20605778 +Reconstituted Complex +BioGRID:111700 BioGRID:115486 ALYREF BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:106766 AMHR2 BioGRID PMID: 15717329 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:127557 AMOT BioGRID PMID: 31685992,21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:115665 ANAPC10 BioGRID PMID: 31685992 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:118982 ANAPC4 BioGRID PMID: 21241890 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:119537 ANAPC5 BioGRID PMID: 21241890 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:119538 ANAPC7 BioGRID PMID: 31685992,21241890 +Two-hybrid +BioGRID:111700 BioGRID:106780 ANG BioGRID PMID: 16169070 +Affinity Capture-MS +BioGRID:111700 BioGRID:118888 ANKRD11 BioGRID PMID: 30631154 +Two-hybrid +BioGRID:111700 BioGRID:115795 ANP32B BioGRID PMID: 24412244 +Reconstituted Complex +BioGRID:111700 BioGRID:123548 ANP32E BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:106799 ANXA2 BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:106801 ANXA2P2 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:106844 APOD BioGRID PMID: 29117568,28675297 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:106862 AR BioGRID PMID: 15205473 +Affinity Capture-MS +BioGRID:111700 BioGRID:122163 ARAP3 BioGRID PMID: 29117568,28675297 +Reconstituted Complex +BioGRID:111700 BioGRID:106873 ARF4 BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:116720 ARHGAP26 BioGRID PMID: 15717329 +Negative Genetic +BioGRID:111700 BioGRID:113894 ARID1A BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:123866 ARMC2 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:119614 ARMCX3 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:106901 ARRB1 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:116170 ASCC3 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:127385 ASPRV1 BioGRID PMID: 28675297 +Reconstituted Complex +BioGRID:111700 BioGRID:106987 ATP5F1A BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:106997 ATP5F1C BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:107028 ATRX BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:231572 Aars BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:225601 Acat1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:225610 Acat2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:222369 Acly BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:197943 Acta1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:197944 Actb BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:207569 Actr1a BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:216504 Actr3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:211439 Ahnak BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198069 Akr1b3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198063 Aldh1a1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:204918 Aldh1a7 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:201194 Anxa1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:229475 Arcn1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198253 Atp5a1 BioGRID PMID: 18307411 +Negative Genetic +BioGRID:111700 BioGRID:115919 B3GNT2 BioGRID PMID: 28319085 +Positive Genetic +BioGRID:111700 BioGRID:114246 B4GALT3 BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:114908 BAG2 BioGRID PMID: 32249768 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:113911 BAP1 BioGRID PMID: 34094668,33155366,15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:121304 BBX BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:114934 BCAR1 BioGRID PMID: 9927060 +Affinity Capture-MS +BioGRID:111700 BioGRID:107065 BCKDHA BioGRID PMID: 21532586 +Two-hybrid +BioGRID:111700 BioGRID:120961 BEX1 BioGRID PMID: 25640309 +Affinity Capture-RNA; Protein-RNA +BioGRID:111700 BioGRID:3196665 BGLT3 BioGRID PMID: 33543443 +Affinity Capture-MS +BioGRID:111700 BioGRID:121521 BIRC6 BioGRID PMID: 30631154 +Synthetic Growth Defect +BioGRID:111700 BioGRID:108917 BLOC1S1 BioGRID PMID: 24104479 +Affinity Capture-Western +BioGRID:111700 BioGRID:107116 BMI1 BioGRID PMID: 19903340 +Affinity Capture-MS +BioGRID:111700 BioGRID:116850 BOP1 BioGRID PMID: 32249768 +Positive Genetic +BioGRID:111700 BioGRID:107141 BRAF BioGRID PMID: 28319113 +Negative Genetic +BioGRID:111700 BioGRID:117036 BRD4 BioGRID PMID: 28319113 +Reconstituted Complex +BioGRID:111700 BioGRID:114621 BUB3 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:126002 C2CD4C BioGRID PMID: 30631154 +Negative Genetic +BioGRID:111700 BioGRID:107224 CA11 BioGRID PMID: 35559673 +Two-hybrid +BioGRID:111700 BioGRID:135670 CACTIN-AS1 BioGRID PMID: 21653829 +Reconstituted Complex +BioGRID:111700 BioGRID:107243 CAD BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:107252 CALM1 BioGRID PMID: 26561776 +Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:107268 CAMK2G BioGRID PMID: 28636948 +Affinity Capture-MS; Negative Genetic +BioGRID:111700 BioGRID:120937 CAND1 BioGRID PMID: 32249768,28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:122431 CAPRIN2 BioGRID PMID: 30631154 +Synthetic Growth Defect +BioGRID:111700 BioGRID:122730 CARS2 BioGRID PMID: 24104479 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:107291 CASP8 BioGRID PMID: 15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:107297 CAT BioGRID PMID: 29117568 +Affinity Capture-Western +BioGRID:111700 BioGRID:107305 CAV1 BioGRID PMID: 12176037 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:107315 CBL BioGRID PMID: 34831026,23118026 +Two-hybrid +BioGRID:111700 BioGRID:1527673 CCDC180 BioGRID PMID: 24412244 +Reconstituted Complex +BioGRID:111700 BioGRID:121318 CCDC47 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:122854 CCDC7 BioGRID PMID: 30631154 +FRET +BioGRID:111700 BioGRID:107334 CCND2 BioGRID PMID: 28205554 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:114582 CCNE2 BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:115827 CCT2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:113054 CCT3 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115826 CCT4 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:107346 CCT6A BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115933 CCT8 BioGRID PMID: 31685992 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:107431 CDC27 BioGRID PMID: 21241890 +Synthetic Growth Defect +BioGRID:111700 BioGRID:127125 CDC42EP5 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:107436 CDH3 BioGRID PMID: 30631154 +Positive Genetic +BioGRID:111700 BioGRID:107454 CDK4 BioGRID PMID: 28319113 +Positive Genetic +BioGRID:111700 BioGRID:107463 CDKN2A BioGRID PMID: 28319113 +Affinity Capture-MS +BioGRID:111700 BioGRID:107472 CDSN BioGRID PMID: 29117568 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:107489 CENPC BioGRID PMID: 17218262,15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:124865 CENPL BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:116641 CEP131 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:116506 CEP162 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:115193 CEP170 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:122737 CEP97 BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:107098 CFB BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:107499 CFL1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:107533 CHD4 BioGRID PMID: 31685992 +Negative Genetic +BioGRID:111700 BioGRID:107536 CHEK1 BioGRID PMID: 28319113 +Two-hybrid +BioGRID:111700 BioGRID:107539 CHGB BioGRID PMID: 16169070 +Affinity Capture-MS +BioGRID:111700 BioGRID:1147424 CHMP4BP1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:117547 CHTOP BioGRID PMID: 32249768 +Affinity Capture-Western +BioGRID:111700 BioGRID:107569 CHUK BioGRID PMID: 26787927 +Affinity Capture-MS +BioGRID:111700 BioGRID:107573 CIRBP BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:116167 CKAP4 BioGRID PMID: 29117568 +Affinity Capture-MS +BioGRID:111700 BioGRID:116769 CLCC1 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:125512 CLNK BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:120993 CMAS BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:125251 CMTM1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:113387 CNBP BioGRID PMID: 32249768 +Negative Genetic +BioGRID:111700 BioGRID:110912 CNOT4 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:125533 CNTROB BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:107709 COPA BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:107710 COPB1 BioGRID PMID: 31685992 +Two-hybrid +BioGRID:111700 BioGRID:116176 COPS6 BioGRID PMID: 16169070 +Negative Genetic +BioGRID:111700 BioGRID:125940 COX6B2 BioGRID PMID: 35559673 +Biochemical Activity +BioGRID:111700 BioGRID:107775 CREB1 BioGRID PMID: 31217297 +Affinity Capture-MS +BioGRID:111700 BioGRID:107789 CRKL BioGRID PMID: 15717329 +Negative Genetic +BioGRID:111700 BioGRID:107832 CSK BioGRID PMID: 35559673 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:107836 CSNK1A1 BioGRID PMID: 29593330 +Affinity Capture-MS; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:107841 CSNK2A1 BioGRID PMID: 31685992,25047839,15717329,12297295 +Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:107842 CSNK2A2 BioGRID PMID: 31685992,12297295 +Positive Genetic +BioGRID:111700 BioGRID:107869 CTBP1 BioGRID PMID: 28319085 +Affinity Capture-Western +BioGRID:111700 BioGRID:107880 CTNNB1 BioGRID PMID: 20372837 +Affinity Capture-Western +BioGRID:111700 BioGRID:114032 CUL1 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:114029 CUL4A BioGRID PMID: 30945288 +Biochemical Activity +BioGRID:111700 BioGRID:114028 CUL4B BioGRID PMID: 29499938 +Two-hybrid +BioGRID:111700 BioGRID:109176 CXCL1 BioGRID PMID: 25640309 +Affinity Capture-Western; Two-hybrid +BioGRID:111700 BioGRID:119045 CXXC1 BioGRID PMID: 21653829 +Synthetic Growth Defect +BioGRID:111700 BioGRID:108071 CYB5R3 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:198468 Cap1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198471 Capn2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198565 Cct3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198567 Cct4 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198568 Cct5 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198569 Cct6a BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198571 Cct7 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198684 Cfl1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198685 Cfl2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:212086 Cltc BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:206180 Ctps BioGRID PMID: 18307411 +Reconstituted Complex +BioGRID:111700 BioGRID:113587 DAP3 BioGRID PMID: 31685992 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:107985 DAXX BioGRID PMID: 28497778 +Affinity Capture-MS +BioGRID:111700 BioGRID:123157 DBF4B BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:107995 DBN1 BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:107997 DBT BioGRID PMID: 21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:123251 DCAF11 BioGRID PMID: 26561776 +Affinity Capture-MS; Affinity Capture-Western; Two-hybrid +BioGRID:111700 BioGRID:117393 DCAF13 BioGRID PMID: 29499938 +Reconstituted Complex +BioGRID:111700 BioGRID:108009 DDB1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:108017 DDOST BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:108019 DDX1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:114625 DDX21 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:121353 DDX24 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:119375 DDX47 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:122480 DDX50 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:114095 DGKZ BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:108029 DHX15 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:108025 DHX9 BioGRID PMID: 31685992 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:115667 DLC1 BioGRID PMID: 19482022 +Co-fractionation; Reconstituted Complex +BioGRID:111700 BioGRID:108083 DLG1 BioGRID PMID: 11707428,11439092 +Affinity Capture-MS +BioGRID:111700 BioGRID:126999 DNAAF8 BioGRID PMID: 33961781 +Reconstituted Complex +BioGRID:111700 BioGRID:109534 DNAJA1 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:115582 DNAJA2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:114547 DNAJA3 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115360 DNAJB6 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:119947 DNAJC10 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:117946 DNAJC2 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:114340 DPM1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:110810 DRG1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:108162 DSG1 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:108166 DSP BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:108187 DUT BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:108189 DVL2 BioGRID PMID: 34299191 +Affinity Capture-MS +BioGRID:111700 BioGRID:199084 Ddx3x BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:207975 Dstn BioGRID PMID: 18307411 +Affinity Capture-Western +BioGRID:111700 BioGRID:108201 E2F1 BioGRID PMID: 29108454 +Affinity Capture-Western +BioGRID:111700 BioGRID:567392 ECSCR BioGRID PMID: 21593423 +Negative Genetic +BioGRID:111700 BioGRID:114265 EED BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:108238 EEF1A2 BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:108258 EEF2 BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:121953 EEFSEC BioGRID PMID: 30631154 +Affinity Capture-Western; Positive Genetic +BioGRID:111700 BioGRID:108276 EGFR BioGRID PMID: 34831026,31741433,26531778 +Affinity Capture-Western +BioGRID:111700 BioGRID:108278 EGR1 BioGRID PMID: 21354147 +Affinity Capture-Western +BioGRID:111700 BioGRID:111596 EIF2AK2 BioGRID PMID: 20029030 +Reconstituted Complex +BioGRID:111700 BioGRID:108292 EIF4E BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:109898 EIF6 BioGRID PMID: 31685992 +Affinity Capture-RNA +BioGRID:111700 BioGRID:108309 ELAVL1 BioGRID PMID: 19322201 +Negative Genetic +BioGRID:111700 BioGRID:116595 ELL2 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:127829 ELOA3P BioGRID PMID: 15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:114090 ELP1 BioGRID PMID: 32249768 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:108325 EMD BioGRID PMID: 32249768,31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:128252 EME2 BioGRID PMID: 24104479 +Two-hybrid +BioGRID:111700 BioGRID:108324 EML1 BioGRID PMID: 21653829 +Synthetic Growth Defect +BioGRID:111700 BioGRID:108340 ENO2 BioGRID PMID: 24104479 +FRET +BioGRID:111700 BioGRID:108288 EPHA2 BioGRID PMID: 28205554 +Affinity Capture-Western +BioGRID:111700 BioGRID:108361 EPHB1 BioGRID PMID: 23118026 +Reconstituted Complex +BioGRID:111700 BioGRID:108372 EPRS1 BioGRID PMID: 31685992 +Two-hybrid +BioGRID:111700 BioGRID:108377 ERBB3 BioGRID PMID: 28065597 +Reconstituted Complex +BioGRID:111700 BioGRID:108403 ESR1 BioGRID PMID: 15205473 +Affinity Capture-MS +BioGRID:111700 BioGRID:108414 ETS1 BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:115884 EXOC5 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:119220 EXOSC1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116977 EXOSC2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:120007 EXOSC4 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:121243 EXOSC5 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116658 EXOSC7 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:108440 EYA2 BioGRID PMID: 28675297 +Positive Genetic +BioGRID:111700 BioGRID:108446 EZH2 BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:199385 Eef1a1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:207744 Eef1b2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:211625 Eef1d BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:211986 Eef1g BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:199387 Eef2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:199418 Eif4a1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:199451 Eno1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:199507 Esd BioGRID PMID: 18307411 +Negative Genetic +BioGRID:111700 BioGRID:123086 FAM106A BioGRID PMID: 35559673 +Reconstituted Complex +BioGRID:111700 BioGRID:108487 FARSA BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115367 FARSB BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:108488 FASN BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:108399 FBL BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:108495 FBN2 BioGRID PMID: 15717329 +Co-localization +BioGRID:111700 BioGRID:117625 FBXL5 BioGRID PMID: 30257389 +Synthetic Growth Defect +BioGRID:111700 BioGRID:117624 FBXL6 BioGRID PMID: 24104479 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:117649 FBXO22 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:116887 FBXW11 BioGRID PMID: 31685992 +Affinity Capture-Western +BioGRID:111700 BioGRID:120581 FBXW7 BioGRID PMID: 23514585 +Affinity Capture-MS +BioGRID:111700 BioGRID:108528 FEN1 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:108579 FKBP5 BioGRID PMID: 29117568,28675297 +Two-hybrid +BioGRID:111700 BioGRID:108605 FLNA BioGRID PMID: 21653829 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:108606 FLNB BioGRID PMID: 32249768,26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:116686 FNBP1 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:128769 FOXK1 BioGRID PMID: 31685992 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:108726 FRK BioGRID PMID: 19345329 +Affinity Capture-MS +BioGRID:111700 BioGRID:3188904 FSBP BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:112508 FSCN1 BioGRID PMID: 31298480 +Affinity Capture-MS +BioGRID:111700 BioGRID:134873 FSIP2 BioGRID PMID: 30631154 +Phenotypic Enhancement +BioGRID:111700 BioGRID:114399 FUBP1 BioGRID PMID: 31553912 +Reconstituted Complex +BioGRID:111700 BioGRID:114451 FUBP3 BioGRID PMID: 31685992 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:119489 FZR1 BioGRID PMID: 24811168,21241890 +Affinity Capture-MS +BioGRID:111700 BioGRID:199596 Fasn BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:228662 Flna BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:231475 Fus BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:115237 G3BP2 BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:119102 GEMIN4 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:108943 GFRA2 BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:109032 GNAI1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:109033 GNAI2 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:121887 GNB4 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:117690 GNL3 BioGRID PMID: 31685992 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:109079 GPC1 BioGRID PMID: 30631154,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:108530 GPC4 BioGRID PMID: 26561776 +Synthetic Growth Defect +BioGRID:111700 BioGRID:109110 GPER1 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:118086 GPKOW BioGRID PMID: 32249768 +Affinity Capture-Western +BioGRID:111700 BioGRID:109142 GRB2 BioGRID PMID: 31320611 +Reconstituted Complex +BioGRID:111700 BioGRID:109201 GSTM2 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:109231 GTF3C2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:114739 GTF3C3 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:114737 GTF3C5 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:199892 Gdi2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:588567 Gm16470 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:578322 Gm8129 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:109260 H1-0 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:113931 H2AC4 BioGRID PMID: 26561776 +Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:109268 H2AX BioGRID PMID: 31217297 +Reconstituted Complex +BioGRID:111700 BioGRID:109280 HADHA BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:123991 HAGHL BioGRID PMID: 24104479 +Two-hybrid +BioGRID:111700 BioGRID:109289 HBA1 BioGRID PMID: 16169070 +Affinity Capture-MS +BioGRID:111700 BioGRID:109293 HBB BioGRID PMID: 29117568 +Affinity Capture-MS +BioGRID:111700 BioGRID:115330 HDAC6 BioGRID PMID: 30631154 +Synthetic Growth Defect +BioGRID:111700 BioGRID:121976 HEATR6 BioGRID PMID: 24104479 +Synthetic Growth Defect +BioGRID:111700 BioGRID:132759 HES5 BioGRID PMID: 24104479 +Synthetic Growth Defect +BioGRID:111700 BioGRID:120682 HES6 BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:109420 HNRNPA1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:128670 HNRNPA3 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:109423 HNRNPAB BioGRID PMID: 31685992 +Affinity Capture-RNA +BioGRID:111700 BioGRID:109432 HNRNPL BioGRID PMID: 28611215 +Affinity Capture-MS +BioGRID:111700 BioGRID:109433 HNRNPU BioGRID PMID: 21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:116281 HNRNPUL1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:121926 HPSE2 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:109525 HSD17B1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:109278 HSD17B10 BioGRID PMID: 31685992 +Affinity Capture-MS; Positive Genetic +BioGRID:111700 BioGRID:109552 HSP90AA1 BioGRID PMID: 28319113,21532586 +Affinity Capture-MS; Positive Genetic; Reconstituted Complex +BioGRID:111700 BioGRID:109558 HSP90AB1 BioGRID PMID: 28319085,26561776,21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:113036 HSP90B1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:109535 HSPA1A BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:109537 HSPA1L BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:109538 HSPA2 BioGRID PMID: 21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:109540 HSPA4 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116500 HSPA4L BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:109542 HSPA6 BioGRID PMID: 21532586 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:109544 HSPA8 BioGRID PMID: 26561776,21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:117168 HSPBP1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:109561 HSPD1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:116022 HSPH1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:207301 Hnrnpa2b1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:230827 Hnrnpa3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:221126 Hnrnpf BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200359 Hnrnpk BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200360 Hnrnpl BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:206185 Hnrnpu BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200455 Hsp90aa1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200454 Hsp90ab1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:204301 Hsp90b1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200456 Hspa4 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200078 Hspa5 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200428 Hspa8 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:200451 Hspd1 BioGRID PMID: 18307411 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:109642 IDE BioGRID PMID: 30649986,28675297 +Synthetic Growth Defect +BioGRID:111700 BioGRID:122082 IFIH1 BioGRID PMID: 24104479 +Negative Genetic +BioGRID:111700 BioGRID:109701 IGF1R BioGRID PMID: 28319085 +Negative Genetic +BioGRID:111700 BioGRID:115886 IGF2BP1 BioGRID PMID: 28319085 +Positive Genetic +BioGRID:111700 BioGRID:109703 IGF2R BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:130074 IGSF10 BioGRID PMID: 30631154 +Two-hybrid +BioGRID:111700 BioGRID:116199 IL24 BioGRID PMID: 25640309 +Reconstituted Complex +BioGRID:111700 BioGRID:109821 ILF2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:109822 ILF3 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:123742 INHBE BioGRID PMID: 15717329 +Biochemical Activity +BioGRID:111700 BioGRID:109842 INS BioGRID PMID: 11439092 +Affinity Capture-MS +BioGRID:111700 BioGRID:122828 IPO4 BioGRID PMID: 29117568,28675297 +Reconstituted Complex +BioGRID:111700 BioGRID:110041 IPO5 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115782 IPO7 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:132986 IQCF2 BioGRID PMID: 30631154 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:114048 IRS4 BioGRID PMID: 31685992,15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:109864 ITGA6 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:109901 ITGB7 BioGRID PMID: 30631154 +Affinity Capture-Western +BioGRID:111700 BioGRID:109915 ITPR3 BioGRID PMID: 28614300 +Reconstituted Complex +BioGRID:111700 BioGRID:112622 ITPRID2 BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:200510 Idh1 BioGRID PMID: 18307411 +Reconstituted Complex +BioGRID:111700 BioGRID:109931 JUP BioGRID PMID: 26561776 +Affinity Capture-Western +BioGRID:111700 BioGRID:114375 KAT2B BioGRID PMID: 16829519 +Reconstituted Complex +BioGRID:111700 BioGRID:120833 KBTBD4 BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:114086 KCNAB2 BioGRID PMID: 32249768 +Negative Genetic +BioGRID:111700 BioGRID:116145 KDELR1 BioGRID PMID: 35559673 +Reconstituted Complex +BioGRID:111700 BioGRID:116667 KDM1A BioGRID PMID: 31685992 +Positive Genetic +BioGRID:111700 BioGRID:113246 KDM6A BioGRID PMID: 28319113 +Negative Genetic +BioGRID:111700 BioGRID:114139 KHSRP BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:110030 KIF11 BioGRID PMID: 30631154 +Affinity Capture-Western +BioGRID:111700 BioGRID:107153 KLF5 BioGRID PMID: 35780838 +Affinity Capture-Western +BioGRID:111700 BioGRID:110443 KMT2A BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:110035 KPNB1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:110059 KRT14 BioGRID PMID: 15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:110048 KRT3 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:133686 KRT39 BioGRID PMID: 30631154 +Biochemical Activity +BioGRID:111700 BioGRID:114563 LATS1 BioGRID PMID: 22641346 +Affinity Capture-MS +BioGRID:111700 BioGRID:110131 LDHA BioGRID PMID: 32249768 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:110137 LDHB BioGRID PMID: 32249768,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:110147 LGALS1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:119559 LIMA1 BioGRID PMID: 26561776 +Protein-RNA +BioGRID:111700 BioGRID:124305 LINC00839 BioGRID PMID: 30631154 +Affinity Capture-RNA; Protein-RNA +BioGRID:111700 BioGRID:3193082 LINC01198 BioGRID PMID: 31469661 +Affinity Capture-RNA; Protein-RNA +BioGRID:111700 BioGRID:3192300 LINC02023 BioGRID PMID: 30849479 +Synthetic Growth Defect +BioGRID:111700 BioGRID:110181 LLGL2 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:110186 LMNA BioGRID PMID: 29117568 +Reconstituted Complex +BioGRID:111700 BioGRID:110187 LMNB1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115432 LRPPRC BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:124379 LTV1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:113574 LUZP1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:121406 LYRM1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:201127 Ldha BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:201142 Lgals1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:201143 Lgals3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:201191 Lox BioGRID PMID: 18307411 +Reconstituted Complex +BioGRID:111700 BioGRID:116121 MAGED2 BioGRID PMID: 31685992 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:115197 MAGI2 BioGRID PMID: 11707428,10760291 +Affinity Capture-Western; Reconstituted Complex; Two-hybrid +BioGRID:111700 BioGRID:129277 MAGI3 BioGRID PMID: 10748157 +Positive Genetic +BioGRID:111700 BioGRID:110294 MAN1A1 BioGRID PMID: 28319085 +Negative Genetic +BioGRID:111700 BioGRID:116414 MAN1B1 BioGRID PMID: 28319085 +FRET +BioGRID:111700 BioGRID:111592 MAP2K3 BioGRID PMID: 28205554 +Affinity Capture-MS +BioGRID:111700 BioGRID:111594 MAP2K6 BioGRID PMID: 15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:111580 MAPK1 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:110257 MARCKS BioGRID PMID: 32249768 +Co-crystal Structure; Reconstituted Complex +BioGRID:111700 BioGRID:116756 MAST2 BioGRID PMID: 22894835 +Reconstituted Complex +BioGRID:111700 BioGRID:115126 MATR3 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:121249 MCCC1 BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:122050 MCCC2 BioGRID PMID: 21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:110339 MCM2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:110340 MCM3 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:110342 MCM5 BioGRID PMID: 31685992 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:110344 MCM7 BioGRID PMID: 32249768,31685992 +Affinity Capture-Western; Far Western; Reconstituted Complex +BioGRID:111700 BioGRID:115710 MCRS1 BioGRID PMID: 15659546 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:115014 MDC1 BioGRID PMID: 31217297 +Reconstituted Complex +BioGRID:111700 BioGRID:116804 MDN1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:115293 MED12 BioGRID PMID: 15717329 +Positive Genetic +BioGRID:111700 BioGRID:110391 MET BioGRID PMID: 28319113 +Affinity Capture-MS +BioGRID:111700 BioGRID:122519 METTL16 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:124050 METTL26 BioGRID PMID: 26561776 +Affinity Capture-MS; Biochemical Activity +BioGRID:111700 BioGRID:119471 MEX3C BioGRID PMID: 30741721,30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:134376 MEX3D BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:110434 MKI67 BioGRID PMID: 31685992 +Affinity Capture-Western; Co-localization; Reconstituted Complex +BioGRID:111700 BioGRID:110455 MME BioGRID PMID: 20957047,14749127 +Positive Genetic +BioGRID:111700 BioGRID:113599 MOGS BioGRID PMID: 28319085 +Reconstituted Complex; Two-hybrid +BioGRID:111700 BioGRID:116776 MPRIP BioGRID PMID: 26561776,21653829 +Affinity Capture-MS +BioGRID:111700 BioGRID:122369 MRPL11 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:121269 MRPS22 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:119657 MRPS23 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116731 MRPS27 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:118784 MRPS28 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:119271 MRPS7 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:122360 MRPS9 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:109211 MSH6 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:110622 MTHFD1 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:116011 MTHFD2 BioGRID PMID: 26561776 +Negative Genetic +BioGRID:111700 BioGRID:108757 MTOR BioGRID PMID: 28319113 +Negative Genetic +BioGRID:111700 BioGRID:125018 MVB12A BioGRID PMID: 35559673 +Affinity Capture-Western; Reconstituted Complex; Two-hybrid +BioGRID:111700 BioGRID:115286 MVP BioGRID PMID: 12177006 +Synthetic Growth Defect +BioGRID:111700 BioGRID:110259 MXD1 BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:115770 MYBBP1A BioGRID PMID: 31685992 +FRET +BioGRID:111700 BioGRID:110694 MYC BioGRID PMID: 28205554 +Reconstituted Complex +BioGRID:111700 BioGRID:110713 MYH10 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:115871 MYL12A BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:110567 MYO1B BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:110725 MYO1C BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:110726 MYO1D BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:117715 MYOF BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:201584 Map1b BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:211799 Mtap BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:201650 Myh9 BioGRID PMID: 18307411 +Reconstituted Complex +BioGRID:111700 BioGRID:110748 NACA BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:110766 NCBP1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:575724 NCF1 BioGRID PMID: 26561776 +Affinity Capture-Western +BioGRID:111700 BioGRID:113841 NCOA3 BioGRID PMID: 23514585 +Affinity Capture-MS +BioGRID:111700 BioGRID:114974 NCOR2 BioGRID PMID: 30631154 +Affinity Capture-Western; PCA +BioGRID:111700 BioGRID:123296 NDFIP1 BioGRID PMID: 24798731,22213801,20534535 +Affinity Capture-Western +BioGRID:111700 BioGRID:120074 NDFIP2 BioGRID PMID: 20534535 +Negative Genetic +BioGRID:111700 BioGRID:110797 NDUFC1 BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:125728 NEDD1 BioGRID PMID: 30631154 +Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:110811 NEDD4 BioGRID PMID: 33712741,31578285,31469661,30594392,29593330,28437168,27295432,25547115,25047839,24141722,24063548,21986318,19345329,18498243,18307411 +Positive Genetic +BioGRID:111700 BioGRID:110836 NF1 BioGRID PMID: 28319113 +Negative Genetic +BioGRID:111700 BioGRID:118095 NFU1 BioGRID PMID: 35559673 +Reconstituted Complex +BioGRID:111700 BioGRID:121798 NGB BioGRID PMID: 23904011 +Affinity Capture-MS; Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid +BioGRID:111700 BioGRID:114769 NHERF1 BioGRID PMID: 30631154,26531778,23118026,21990315,21804599,16456542 +Reconstituted Complex +BioGRID:111700 BioGRID:1172218 NHERF1 BioGRID PMID: 21990315 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:114754 NHERF2 BioGRID PMID: 16456542 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:110894 NME1 BioGRID PMID: 32249768,26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:117586 NOC2L BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:115783 NOP56 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:119631 NOP58 BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:110913 NOTCH1 BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:115640 NPM3 BioGRID PMID: 31685992 +Positive Genetic +BioGRID:111700 BioGRID:113796 NPRL3 BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:110953 NRCAM BioGRID PMID: 30631154 +Affinity Capture-Western +BioGRID:111700 BioGRID:113306 NSD2 BioGRID PMID: 31217297 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:114202 NUMB BioGRID PMID: 28437168 +Affinity Capture-MS +BioGRID:111700 BioGRID:207325 Nap1l1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:213922 Nars BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:201706 Ncl BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:201723 Nedd4 BioGRID PMID: 18307411 +Affinity Capture-Western +BioGRID:111700 BioGRID:211159 Nherf2 BioGRID PMID: 16456542 +Affinity Capture-MS +BioGRID:111700 BioGRID:201823 Npm1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:110996 OAT BioGRID PMID: 32249768 +Synthetic Growth Defect +BioGRID:111700 BioGRID:111032 OPRL1 BioGRID PMID: 24104479 +Synthetic Growth Defect +BioGRID:111700 BioGRID:117263 OSBP2 BioGRID PMID: 24104479 +Two-hybrid +BioGRID:111700 BioGRID:118985 OSGIN1 BioGRID PMID: 25640309 +Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:116856 OTUD3 BioGRID PMID: 33543443,26280536 +Affinity Capture-Western +BioGRID:111700 BioGRID:120738 OTUD5 BioGRID PMID: 35765958 +Affinity Capture-MS +BioGRID:111700 BioGRID:211895 Oxct1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:111071 P2RY11 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:115855 P3H4 BioGRID PMID: 15717329 +Negative Genetic +BioGRID:111700 BioGRID:124145 PARD6B BioGRID PMID: 35559673 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:116446 PARK7 BioGRID PMID: 31891690,30631154,21426932,19885556 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:120971 PBK BioGRID PMID: 24012691 +Reconstituted Complex +BioGRID:111700 BioGRID:120490 PBRM1 BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:111123 PBX3 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:111124 PC BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:111128 PCCA BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:111129 PCCB BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:121046 PCDHGA10 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:111142 PCNA BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:111182 PDGFRA BioGRID PMID: 15717329 +Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex +BioGRID:111700 BioGRID:111185 PDGFRB BioGRID PMID: 25241761,14718524 +Affinity Capture-MS +BioGRID:111700 BioGRID:111186 PDHA1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:129119 PDZD9 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:119818 PELO BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:117973 PELP1 BioGRID PMID: 31685992 +Affinity Capture-Western +BioGRID:111700 BioGRID:111237 PFN1 BioGRID PMID: 26787927 +Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:111251 PGK1 BioGRID PMID: 32249768,31492635 +Reconstituted Complex +BioGRID:111700 BioGRID:111264 PHB1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116459 PHB2 BioGRID PMID: 31685992 +Affinity Capture-Western; Two-hybrid +BioGRID:111700 BioGRID:114849 PICK1 BioGRID PMID: 21653829 +Negative Genetic +BioGRID:111700 BioGRID:111301 PIGH BioGRID PMID: 35559673 +Synthetic Growth Defect +BioGRID:111700 BioGRID:117100 PIGN BioGRID PMID: 24104479 +Affinity Capture-Western; FRET +BioGRID:111700 BioGRID:111313 PIK3R1 BioGRID PMID: 34831026,20212113 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:111314 PIK3R2 BioGRID PMID: 20515662 +Affinity Capture-MS +BioGRID:111700 BioGRID:122376 PINK1 BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:111332 PKM BioGRID PMID: 26561776 +Synthetic Growth Defect +BioGRID:111700 BioGRID:114544 PKMYT1 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:111572 PKN2 BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:111355 PLEC BioGRID PMID: 26561776 +Proximity Label-MS +BioGRID:111700 BioGRID:121880 PLEKHA1 BioGRID PMID: 27880917 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:111362 PLK1 BioGRID PMID: 25047839 +Synthetic Growth Defect +BioGRID:111700 BioGRID:114171 PLPP3 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:123048 POF1B BioGRID PMID: 29117568 +Reconstituted Complex +BioGRID:111700 BioGRID:117531 POLDIP2 BioGRID PMID: 31685992,26561776 +Synthetic Growth Defect +BioGRID:111700 BioGRID:118168 POLM BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:117396 POLR1A BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111426 POLR2A BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111427 POLR2B BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111433 POLR2H BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116140 POP1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111488 PPL BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:111491 PPM1G BioGRID PMID: 28675297 +Affinity Capture-Western +BioGRID:111700 BioGRID:111493 PPP1CA BioGRID PMID: 17274640 +Affinity Capture-MS +BioGRID:111700 BioGRID:111506 PPP1R10 BioGRID PMID: 21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:111507 PPP2CA BioGRID PMID: 31685992 +Affinity Capture-Western +BioGRID:111700 BioGRID:111522 PPP3CA BioGRID PMID: 20605778 +Affinity Capture-MS +BioGRID:111700 BioGRID:111528 PPP5C BioGRID PMID: 28675297 +Reconstituted Complex +BioGRID:111700 BioGRID:111089 PRDX1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:116136 PRDX3 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111577 PRKDC BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:111105 PRKN BioGRID PMID: 35256949,30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:118151 PRPF19 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115842 PRPF8 BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:111663 PSMB2 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:111681 PSMD2 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:111682 PSMD3 BioGRID PMID: 31685992 +Affinity Capture-Western; Co-localization; Reconstituted Complex +BioGRID:111700 BioGRID:111683 PSMD4 BioGRID PMID: 30673593 +Reconstituted Complex +BioGRID:111700 BioGRID:111685 PSMD7 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115135 PTDSS1 BioGRID PMID: 31685992 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:111700 PTEN BioGRID PMID: 30631154,14976311 +Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex +BioGRID:111700 BioGRID:111719 PTK2 BioGRID PMID: 23397142,15717329,11857088,10400703,9927060 +Affinity Capture-MS +BioGRID:111700 BioGRID:108480 PTK2B BioGRID PMID: 15717329 +Two-hybrid +BioGRID:111700 BioGRID:111721 PTK7 BioGRID PMID: 28065597 +Affinity Capture-Western +BioGRID:111700 BioGRID:111516 PTPA BioGRID PMID: 15717329 +Affinity Capture-MS; Proximity Label-MS +BioGRID:111700 BioGRID:111747 PTPN13 BioGRID PMID: 30631154,27880917 +Affinity Capture-MS +BioGRID:111700 BioGRID:111748 PTPN14 BioGRID PMID: 15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:111772 PURA BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:111773 PURB BioGRID PMID: 32249768 +Affinity Capture-Western; Co-localization +BioGRID:111700 BioGRID:111787 PXN BioGRID PMID: 23397142,11857088 +Affinity Capture-MS +BioGRID:111700 BioGRID:204835 Pcbp1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202043 Pcbp2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202049 Pcna BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202126 Pfn1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202133 Pgk1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202191 Pkm BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:234487 Ppia BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202427 Psmc2 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202428 Psmc3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:204845 Psmc4 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:211864 Psmd12 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:212566 Puf60 BioGRID PMID: 18307411 +Reconstituted Complex +BioGRID:111700 BioGRID:120171 QPCTL BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:117035 QPRT BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:123897 QRFPR BioGRID PMID: 15717329 +Positive Genetic +BioGRID:111700 BioGRID:123619 RAB1B BioGRID PMID: 28319085 +Negative Genetic +BioGRID:111700 BioGRID:111816 RAB5C BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:113624 RAB7A BioGRID PMID: 28675297 +Reconstituted Complex +BioGRID:111700 BioGRID:111822 RAD21 BioGRID PMID: 31685992 +Affinity Capture-Western +BioGRID:111700 BioGRID:111825 RAD51 BioGRID PMID: 31320611 +Negative Genetic +BioGRID:111700 BioGRID:114018 RAD54L BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:111835 RALB BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:115557 RAMP2 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:111839 RANBP2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111840 RANGAP1 BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:115115 RASSF2 BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:111864 RBBP5 BioGRID PMID: 31685992 +Affinity Capture-Western +BioGRID:111700 BioGRID:115862 RBCK1 BioGRID PMID: 35174471 +Reconstituted Complex +BioGRID:111700 BioGRID:111871 RBM4 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:121001 RCC2 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:111887 RCN1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111915 RFC3 BioGRID PMID: 31685992 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:111916 RFC4 BioGRID PMID: 32249768,31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111917 RFC5 BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:116792 RFTN1 BioGRID PMID: 24104479 +Affinity Capture-Western +BioGRID:111700 BioGRID:106880 RHOA BioGRID PMID: 22720799 +Reconstituted Complex +BioGRID:111700 BioGRID:111947 RING1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:123743 RIOK1 BioGRID PMID: 30631154 +Affinity Capture-Western +BioGRID:111700 BioGRID:120790 RNF126 BioGRID PMID: 33664240 +Affinity Capture-Western +BioGRID:111700 BioGRID:123598 RNF146 BioGRID PMID: 25547115 +Affinity Capture-MS +BioGRID:111700 BioGRID:112037 RPA1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:123917 RPF2 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:112054 RPL10 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:110813 RPL10A BioGRID PMID: 31685992,26561776 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:112056 RPL12 BioGRID PMID: 32249768,31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112057 RPL13 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:117068 RPL13A BioGRID PMID: 26561776 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:114507 RPL14 BioGRID PMID: 31685992,26561776,15717329 +Reconstituted Complex +BioGRID:111700 BioGRID:112059 RPL17 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112062 RPL18A BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112064 RPL21 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112066 RPL22 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:128356 RPL22L1 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:114752 RPL23 BioGRID PMID: 31685992,26561776 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:112067 RPL23A BioGRID PMID: 32249768,31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:112073 RPL26 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:112074 RPL27 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112076 RPL27A BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112077 RPL28 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112075 RPL30 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112079 RPL31 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112080 RPL32 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112083 RPL34 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:117388 RPL36 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112088 RPL38 BioGRID PMID: 31685992,26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:112045 RPL5 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:112048 RPL6 BioGRID PMID: 32249768 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:112049 RPL7 BioGRID PMID: 32249768,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112094 RPLP0 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112096 RPLP2 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112100 RPN2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115807 RPP30 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115808 RPP38 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116013 RPP40 BioGRID PMID: 31685992 +Negative Genetic +BioGRID:111700 BioGRID:121820 RPRD1B BioGRID PMID: 35559673 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:112119 RPS11 BioGRID PMID: 32249768,31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112121 RPS13 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112123 RPS15 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112124 RPS15A BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112132 RPS17 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112101 RPS2 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112138 RPS20 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112142 RPS23 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112144 RPS25 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112145 RPS26 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112146 RPS27 BioGRID PMID: 31685992,26561776 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:112147 RPS27A BioGRID PMID: 30631154,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112102 RPS3 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112105 RPS4X BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112107 RPS5 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112108 RPS6 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112117 RPS9 BioGRID PMID: 31685992,26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:121582 RPTOR BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:125221 RPUSD1 BioGRID PMID: 33961781 +Reconstituted Complex +BioGRID:111700 BioGRID:117587 RSL1D1 BioGRID PMID: 31685992 +Two-hybrid +BioGRID:111700 BioGRID:116997 RYBP BioGRID PMID: 21653829 +Affinity Capture-MS +BioGRID:111700 BioGRID:112175 RYR3 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:199978 Rack1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:211883 Rpl11 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202968 Rpl18 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:212608 Rpl22l1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:211121 Rpl23 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:205174 Rpl3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:785975 Rpl31-ps9 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198181 Rplp0 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:207787 Rplp1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:203005 Rps17 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:205106 Rps3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:203011 Rps4x BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:203016 Rps7 BioGRID PMID: 18307411 +Reconstituted Complex +BioGRID:111700 BioGRID:112187 S100A8 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112188 S100A9 BioGRID PMID: 26561776 +Positive Genetic +BioGRID:111700 BioGRID:121186 SAR1A BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:131933 SBSN BioGRID PMID: 29117568 +Affinity Capture-MS +BioGRID:111700 BioGRID:112240 SCN10A BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:120810 SCYL2 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:112284 SDC1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112286 SDC4 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112287 SDCBP BioGRID PMID: 26561776 +Negative Genetic +BioGRID:111700 BioGRID:115696 SEC24B BioGRID PMID: 28319085 +Positive Genetic +BioGRID:111700 BioGRID:114991 SEC24C BioGRID PMID: 28319085 +Reconstituted Complex +BioGRID:111700 BioGRID:118968 SEC61A1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:112769 SERPINA7 BioGRID PMID: 32249768 +Negative Genetic +BioGRID:111700 BioGRID:111287 SERPINB6 BioGRID PMID: 35559673 +Reconstituted Complex +BioGRID:111700 BioGRID:112316 SET BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116699 SETX BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:119553 SFMBT1 BioGRID PMID: 30631154 +Affinity Capture-Western +BioGRID:111700 BioGRID:123608 SHARPIN BioGRID PMID: 25152374,20458142 +Affinity Capture-MS +BioGRID:111700 BioGRID:121665 SHROOM3 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:117439 SIN3A BioGRID PMID: 31685992 +Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:116981 SIRT4 BioGRID PMID: 30649986 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:112391 SKP1 BioGRID PMID: 32249768,26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:112447 SLC12A2 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:112464 SLC25A1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115467 SLC25A13 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:111269 SLC25A3 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:106789 SLC25A5 BioGRID PMID: 26561776 +Synthetic Growth Defect +BioGRID:111700 BioGRID:106790 SLC25A6 BioGRID PMID: 24104479 +Synthetic Growth Defect +BioGRID:111700 BioGRID:128503 SLC36A1 BioGRID PMID: 24104479 +Negative Genetic; Reconstituted Complex +BioGRID:111700 BioGRID:112481 SMARCA4 BioGRID PMID: 35559673,31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:114045 SMARCA5 BioGRID PMID: 31685992 +Negative Genetic +BioGRID:111700 BioGRID:112482 SMARCB1 BioGRID PMID: 35559673 +Reconstituted Complex +BioGRID:111700 BioGRID:115841 SMC2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:115362 SMC4 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:116929 SMCHD1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:112416 SMTN BioGRID PMID: 15717329 +Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:121411 SMURF1 BioGRID PMID: 32737433 +Biochemical Activity +BioGRID:111700 BioGRID:112499 SNAI1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:117471 SNED1 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:116661 SNRNP200 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:112510 SNRPA BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:112511 SNRPA1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112513 SNRPB2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112516 SNRPD1 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112528 SNTB2 BioGRID PMID: 26561776 +Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex +BioGRID:111700 BioGRID:123546 SNX27 BioGRID PMID: 32249768,30631154,29117568,28675297 +Affinity Capture-MS; Synthetic Growth Defect +BioGRID:111700 BioGRID:114203 SOCS1 BioGRID PMID: 29991678,24104479 +Negative Genetic +BioGRID:111700 BioGRID:112534 SON BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:126329 SPATA18 BioGRID PMID: 30631154 +Affinity Capture-Western +BioGRID:111700 BioGRID:113993 SPOP BioGRID PMID: 32297747,27622336 +Affinity Capture-MS +BioGRID:111700 BioGRID:112586 SPTA1 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:112587 SPTAN1 BioGRID PMID: 26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112589 SPTBN1 BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:121583 SRGAP1 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:112605 SRP14 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:112330 SRSF7 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:112619 SSB BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:112626 SSR4 BioGRID PMID: 31685992,26561776 +Reconstituted Complex +BioGRID:111700 BioGRID:112627 SSRP1 BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:130764 ST8SIA6 BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:115958 STAG2 BioGRID PMID: 31685992 +Negative Genetic +BioGRID:111700 BioGRID:115863 STAMBP BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:116162 STIP1 BioGRID PMID: 28675297,21532586 +Affinity Capture-Western; Biochemical Activity; Co-localization; Two-hybrid +BioGRID:111700 BioGRID:112670 STK11 BioGRID PMID: 15987703 +Affinity Capture-MS +BioGRID:111700 BioGRID:118032 STK36 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:116342 STRAP BioGRID PMID: 31685992 +Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:115563 STUB1 BioGRID PMID: 34589606,31811908,26280536,22427670 +Reconstituted Complex +BioGRID:111700 BioGRID:122174 SUDS3 BioGRID PMID: 31685992 +Affinity Capture-Western +BioGRID:111700 BioGRID:119676 SUFU BioGRID PMID: 34021128 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:115449 SUGP2 BioGRID PMID: 32249768,31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:112706 SUV39H1 BioGRID PMID: 24104479 +Affinity Capture-MS +BioGRID:111700 BioGRID:198530 Serpinh1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:202142 Slc25a3 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:198105 Slc25a4 BioGRID PMID: 18307411 +Affinity Capture-Luminescence +BioGRID:111700 BioGRID:211376 Smurf2 BioGRID PMID: 19379695 +Affinity Capture-MS +BioGRID:111700 BioGRID:208002 Snd1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:203379 Snrpd1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:203498 Srm BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:125037 TBC1D31 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:116629 TCF25 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:114983 TCL1B BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:112810 TCP1 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:933977 TDRD15 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:114900 TECR BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:119942 TERF2IP BioGRID PMID: 31685992 +Synthetic Growth Defect +BioGRID:111700 BioGRID:112914 THBD BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:121436 THOC2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:124047 THOC3 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:122605 THOC6 BioGRID PMID: 31685992 +Negative Genetic +BioGRID:111700 BioGRID:120647 TMCO6 BioGRID PMID: 35559673 +Two-hybrid +BioGRID:111700 BioGRID:114145 TMEFF1 BioGRID PMID: 24412244 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:114207 TNKS BioGRID PMID: 25547115 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:123257 TNKS2 BioGRID PMID: 25547115 +Affinity Capture-MS +BioGRID:111700 BioGRID:131973 TOPAZ1 BioGRID PMID: 30631154 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:113010 TP53 BioGRID PMID: 24141722,18339852,14559824,12620407 +Affinity Capture-Western; Protein-peptide; Reconstituted Complex +BioGRID:111700 BioGRID:113011 TP53BP1 BioGRID PMID: 31217297 +Affinity Capture-MS +BioGRID:111700 BioGRID:117952 TPK1 BioGRID PMID: 33961781 +Negative Genetic +BioGRID:111700 BioGRID:123063 TRAPPC13 BioGRID PMID: 28319085 +Positive Genetic +BioGRID:111700 BioGRID:112299 TRAPPC2 BioGRID PMID: 28319085 +Positive Genetic +BioGRID:111700 BioGRID:119681 TRAPPC2L BioGRID PMID: 28319085 +Synthetic Growth Defect +BioGRID:111700 BioGRID:114333 TRIM24 BioGRID PMID: 24104479 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:113500 TRIM25 BioGRID PMID: 34416231,33931764,32196840 +Affinity Capture-Western +BioGRID:111700 BioGRID:111919 TRIM27 BioGRID PMID: 31719796 +Reconstituted Complex +BioGRID:111700 BioGRID:115457 TRIM28 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:110678 TRIM37 BioGRID PMID: 33194618 +Affinity Capture-Western +BioGRID:111700 BioGRID:130421 TRIM59 BioGRID PMID: 32165307 +Synthetic Growth Defect +BioGRID:111700 BioGRID:123541 TRIM8 BioGRID PMID: 24104479 +Two-hybrid +BioGRID:111700 BioGRID:119593 TRMO BioGRID PMID: 24412244 +Affinity Capture-MS +BioGRID:111700 BioGRID:123267 TSGA10 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:126962 TTBK2 BioGRID PMID: 15717329 +Synthetic Growth Defect +BioGRID:111700 BioGRID:122175 TTC31 BioGRID PMID: 24104479 +Synthetic Growth Defect +BioGRID:111700 BioGRID:113603 TUBA1A BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:115651 TUBA1B BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:124259 TUBA1C BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:113129 TUBA3C BioGRID PMID: 21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:128444 TUBB BioGRID PMID: 26561776 +Affinity Capture-RNA +BioGRID:111700 BioGRID:113131 TUBB2A BioGRID PMID: 21532586 +Affinity Capture-MS +BioGRID:111700 BioGRID:115654 TUBB3 BioGRID PMID: 21532586 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:115656 TUBB4B BioGRID PMID: 26561776,21532586 +Reconstituted Complex +BioGRID:111700 BioGRID:113135 TUFM BioGRID PMID: 31685992,26561776 +Biochemical Activity +BioGRID:111700 BioGRID:113142 TWIST1 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:113146 TXN BioGRID PMID: 26561776 +Synthetic Growth Defect +BioGRID:111700 BioGRID:119253 TXNDC11 BioGRID PMID: 24104479 +Negative Genetic +BioGRID:111700 BioGRID:113149 TYMS BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:204044 Tcp1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:204290 Tpi1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:204373 Tuba1b BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:216203 Tubb2b BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:230642 Tubb4b BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:785892 Tubb4b-ps1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:204381 Tubb5 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:212561 Tubb6 BioGRID PMID: 18307411 +Affinity Capture-MS; Reconstituted Complex +BioGRID:111700 BioGRID:113157 U2AF1 BioGRID PMID: 32249768,31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:113165 UBA1 BioGRID PMID: 32249768 +Affinity Capture-MS +BioGRID:111700 BioGRID:130617 UBAC2 BioGRID PMID: 35271311 +Synthetic Growth Defect +BioGRID:111700 BioGRID:115227 UBAP2L BioGRID PMID: 24104479 +Affinity Capture-Western; PCA +BioGRID:111700 BioGRID:113164 UBC BioGRID PMID: 24798731 +Synthetic Growth Defect +BioGRID:111700 BioGRID:113169 UBE2D1 BioGRID PMID: 24104479 +Affinity Capture-Western +BioGRID:111700 BioGRID:113177 UBE2I BioGRID PMID: 22713753,12620973 +Affinity Capture-Western +BioGRID:111700 BioGRID:113180 UBE2L3 BioGRID PMID: 12620973 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:118150 UBE2S BioGRID PMID: 34785642,30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:124418 UBL7 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:119239 UBXN1 BioGRID PMID: 32249768 +Reconstituted Complex +BioGRID:111700 BioGRID:111908 UPF1 BioGRID PMID: 31685992 +Negative Genetic +BioGRID:111700 BioGRID:113241 USP1 BioGRID PMID: 35559673 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:114554 USP10 BioGRID PMID: 34416231,30056112,28852924,24270891 +Affinity Capture-Western +BioGRID:111700 BioGRID:113866 USP11 BioGRID PMID: 31592114 +Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex +BioGRID:111700 BioGRID:114465 USP13 BioGRID PMID: 33378983,31200745,26453058,26280536,24270891 +Affinity Capture-Western +BioGRID:111700 BioGRID:118895 USP25 BioGRID PMID: 34805185 +Affinity Capture-MS +BioGRID:111700 BioGRID:115939 USP39 BioGRID PMID: 24270891 +Affinity Capture-MS +BioGRID:111700 BioGRID:113221 USP4 BioGRID PMID: 24270891 +Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:113622 USP7 BioGRID PMID: 31685992,29117568,26280536,24270891,24063548 +Affinity Capture-MS; Affinity Capture-Western +BioGRID:111700 BioGRID:114555 USP8 BioGRID PMID: 24270891 +Affinity Capture-Western; Reconstituted Complex +BioGRID:111700 BioGRID:113867 USP9X BioGRID PMID: 31685992 +Negative Genetic +BioGRID:111700 BioGRID:115503 USPL1 BioGRID PMID: 35559673 +Two-hybrid +BioGRID:111700 BioGRID:116026 UTP14A BioGRID PMID: 16169070 +Reconstituted Complex +BioGRID:111700 BioGRID:113245 UTRN BioGRID PMID: 26561776 +Affinity Capture-MS +BioGRID:111700 BioGRID:204410 Uba1 BioGRID PMID: 18307411 +Affinity Capture-MS +BioGRID:111700 BioGRID:204433 Ugdh BioGRID PMID: 18307411 +Negative Genetic +BioGRID:111700 BioGRID:113269 VHL BioGRID PMID: 28319113 +Positive Genetic +BioGRID:111700 BioGRID:116443 VPS45 BioGRID PMID: 28319085 +Negative Genetic +BioGRID:111700 BioGRID:120563 VPS53 BioGRID PMID: 28319085 +Affinity Capture-MS +BioGRID:111700 BioGRID:234661 Vcp BioGRID PMID: 18307411 +Synthetic Growth Defect +BioGRID:111700 BioGRID:115226 WASHC5 BioGRID PMID: 24104479 +Affinity Capture-Western; Co-localization; Reconstituted Complex +BioGRID:111700 BioGRID:116272 WDR5 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:119939 WNT4 BioGRID PMID: 15717329 +Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:116243 WWP1 BioGRID PMID: 33470109,25547115,21532586 +Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex +BioGRID:111700 BioGRID:116244 WWP2 BioGRID PMID: 35780838,35331737,33039560,31592114,30849479,30016585,28475870,27852060,27295432,24063548,22427670,21532586,15717329 +Affinity Capture-Western; Biochemical Activity +BioGRID:111700 BioGRID:106828 XIAP BioGRID PMID: 22427670,19473982 +Affinity Capture-MS +BioGRID:111700 BioGRID:113345 XPC BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:113353 XRCC5 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:108822 XRCC6 BioGRID PMID: 31685992 +Two-hybrid +BioGRID:111700 BioGRID:115441 YAF2 BioGRID PMID: 21653829 +Biochemical Activity +BioGRID:111700 BioGRID:115684 YAP1 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:113357 YES1 BioGRID PMID: 26561776 +Synthetic Growth Defect +BioGRID:111700 BioGRID:115954 YME1L1 BioGRID PMID: 24104479 +Reconstituted Complex +BioGRID:111700 BioGRID:122321 YTHDC2 BioGRID PMID: 31685992 +Reconstituted Complex +BioGRID:111700 BioGRID:119543 YTHDF2 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:120956 ZC3H15 BioGRID PMID: 30631154 +Negative Genetic +BioGRID:111700 BioGRID:118841 ZC3H7A BioGRID PMID: 35559673 +Affinity Capture-MS +BioGRID:111700 BioGRID:115709 ZER1 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:117299 ZNF318 BioGRID PMID: 30631154 +Reconstituted Complex +BioGRID:111700 BioGRID:129936 ZNF326 BioGRID PMID: 31685992 +Affinity Capture-MS +BioGRID:111700 BioGRID:131374 ZNF391 BioGRID PMID: 30631154 +Affinity Capture-MS +BioGRID:111700 BioGRID:125966 ZNF787 BioGRID PMID: 15717329 +Affinity Capture-MS +BioGRID:111700 BioGRID:122432 ZSCAN18 BioGRID PMID: 33961781 + +GENERAL GENE INFO +------------------------------------------------------------------------------------------------- + +Marker + D10S610 (e-PCR) Links:UniSTS:23815 + PMC20246P1 (e-PCR) Links:UniSTS:271890 + STS-H71499 (e-PCR) Links:UniSTS:5911 + G19918 (e-PCR) Links:UniSTS:77108 + D10S221 (e-PCR) Links:UniSTS:35654 + RH66859 (e-PCR) Links:UniSTS:92239 + RH92455 (e-PCR) Links:UniSTS:85842 + RH122960 (e-PCR) Links:UniSTS:135257 + RH122724 (e-PCR) Links:UniSTS:133995 + AFMA086WG9 (e-PCR) Links:UniSTS:2163 + PTEN_234 (e-PCR) Links:UniSTS:468624 + MARC_17017-17018:1023291848:1 (e-PCR) Links:UniSTS:268185 + Pten (e-PCR), detects polymorphism Links:UniSTS:144288 + WI-18385 (e-PCR) Links:UniSTS:55210 + STS-W73720 (e-PCR) Links:UniSTS:71597 + PMC154149P1 (e-PCR) Links:UniSTS:271292 + PMC88770P1 (e-PCR) Links:UniSTS:273605 + PMC88770P2 (e-PCR) Links:UniSTS:273606 + PMC88770P3 (e-PCR) Links:UniSTS:273607 + RH103681 (e-PCR) Links:UniSTS:98006 + SHGC-111133 (e-PCR) Links:UniSTS:168163 + RH79866 (e-PCR) Links:UniSTS:90866 + +Related pseudogene(s) + 1 foundReview record(s) in Gene, http://130.14.22.59/gene/?Term=related_functional_gene_5728%5Bgroup%5D + +Clone Names + MGC11227 + + +Homology + Orthologs from Annotation Pipeline (/gene/?Term=ortholog_gene_5728[group]): + Orthologs + +Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA) + +Function GO ID Evidence +------------------------------------------------------------------------------------------------- +enables PDZ domain binding GO:0000000 PMID: 10646847,10760291 +enables anaphase-promoting complex bindi... GO:0000000 PMID: 21241890 +enables enzyme binding GO:0000000 PMID: 16845383 +enables identical protein binding GO:0000000 PMID: 24766807 +enables inositol-1,3,4,5-tetrakisphospha... GO:0000000 PMID: 9593664 +enables lipid binding GO:0000000 - +enables myosin phosphatase activity GO:0000000 - +enables phosphatidylinositol-3,4,5-trisp... GO:0000000 PMID: 21873635 +enables phosphatidylinositol-3,4,5-trisp... GO:0000000 PMID: 9593664,9811831 +enables phosphatidylinositol-3,4,5-trisp... GO:0000000 - +enables phosphatidylinositol-3,4-bisphos... GO:0000000 PMID: 9811831 +enables phosphatidylinositol-3,4-bisphos... GO:0000000 - +enables phosphatidylinositol-3-phosphate... GO:0000000 PMID: 9811831 +enables phosphoprotein phosphatase activ... GO:0000000 PMID: 21241890 +enables protein binding GO:0000000 PMID: 15355975,15951562,16456542,17242191,17274640,19345329,19369943,19473982,19903340,21241890,21653829,21804599,23514585,23940795,24012959,24656772,25007873,25241761 +enables protein serine/threonine phospha... GO:0000000 PMID: 9256433 +enables protein tyrosine phosphatase act... GO:0000000 PMID: 21873635 +enables protein tyrosine phosphatase act... GO:0000000 PMID: 9256433 +enables ubiquitin-specific protease bind... GO:0000000 PMID: 26280536 + +Processs GO ID Evidence +------------------------------------------------------------------------------------------------- +involved_in apoptotic process GO:0000000 - +involved_in brain morphogenesis GO:0000000 - +involved_in canonical Wnt signaling path... GO:0000000 PMID: 20123964 +involved_in cell migration GO:0000000 - +involved_in cell motility GO:0000000 PMID: 21873635 +involved_in cellular response to electri... GO:0000000 PMID: 27919618 +involved_in central nervous system devel... GO:0000000 - +involved_in central nervous system myeli... GO:0000000 - +involved_in central nervous system neuro... GO:0000000 - +involved_in dendritic spine morphogenesi... GO:0000000 - +involved_in dentate gyrus development GO:0000000 - +involved_in forebrain morphogenesis GO:0000000 - +involved_in heart development GO:0000000 - +involved_in learning or memory GO:0000000 - +involved_in locomotor rhythm GO:0000000 - +involved_in locomotory behavior GO:0000000 - +involved_in multicellular organismal res... GO:0000000 - +involved_in negative regulation of ERK1 ... GO:0000000 - +involved_in negative regulation of G1/S ... GO:0000000 PMID: 21241890 +involved_in negative regulation of axono... GO:0000000 - +involved_in negative regulation of cell ... GO:0000000 PMID: 10918569 +involved_in negative regulation of cell ... GO:0000000 PMID: 9616126,17880912,21573166 +involved_in negative regulation of cell ... GO:0000000 PMID: 21873635 +involved_in negative regulation of cell ... GO:0000000 PMID: 19057511 +involved_in negative regulation of cell ... GO:0000000 PMID: 10468583,17880912 +involved_in negative regulation of cell ... GO:0000000 - +involved_in negative regulation of cellu... GO:0000000 PMID: 21241890 +involved_in negative regulation of cycli... GO:0000000 PMID: 21241890 +involved_in negative regulation of dendr... GO:0000000 - +involved_in negative regulation of epith... GO:0000000 PMID: 27919618 +involved_in negative regulation of excit... GO:0000000 - +involved_in negative regulation of focal... GO:0000000 PMID: 9616126 +involved_in negative regulation of kerat... GO:0000000 PMID: 27919618 +involved_in negative regulation of neuro... GO:0000000 PMID: 28008308 +involved_in negative regulation of organ... GO:0000000 - +involved_in negative regulation of pepti... GO:0000000 PMID: 10918569 +involved_in negative regulation of phosp... GO:0000000 PMID: 16762633 +involved_in negative regulation of phosp... GO:0000000 PMID: 18082964 +acts_upstream_of_or_within negative regu... GO:0000000 PMID: 26280536 +involved_in negative regulation of prote... GO:0000000 PMID: 10760291,21573166,22879939 +involved_in negative regulation of prote... GO:0000000 - +involved_in negative regulation of prote... GO:0000000 PMID: 20123964 +involved_in negative regulation of prote... GO:0000000 - +involved_in negative regulation of synap... GO:0000000 - +involved_in negative regulation of vascu... GO:0000000 PMID: 26208095 +involved_in negative regulation of wound... GO:0000000 PMID: 27919618 +involved_in neuron-neuron synaptic trans... GO:0000000 - +involved_in phosphatidylinositol 3-kinas... GO:0000000 PMID: 21873635 +involved_in phosphatidylinositol 3-kinas... GO:0000000 PMID: 9593664 +involved_in phosphatidylinositol biosynt... GO:0000000 - +involved_in phosphatidylinositol dephosp... GO:0000000 PMID: 21873635 +involved_in phosphatidylinositol dephosp... GO:0000000 PMID: 9593664,9811831 +involved_in phosphatidylinositol dephosp... GO:0000000 PMID: 21828076 +involved_in positive regulation of DNA-b... GO:0000000 PMID: 20123964 +involved_in positive regulation of TRAIL... GO:0000000 - +involved_in positive regulation of cell ... GO:0000000 - +involved_in positive regulation of excit... GO:0000000 - +involved_in positive regulation of ubiqu... GO:0000000 PMID: 21241890 +involved_in positive regulation of ubiqu... GO:0000000 PMID: 21241890 +involved_in postsynaptic density assembl... GO:0000000 - +involved_in prepulse inhibition GO:0000000 - +involved_in presynaptic membrane assembl... GO:0000000 - +involved_in protein dephosphorylation GO:0000000 PMID: 21873635 +involved_in protein dephosphorylation GO:0000000 PMID: 9256433 +involved_in protein dephosphorylation GO:0000000 PMID: 9367992 +involved_in protein kinase B signaling GO:0000000 - +involved_in protein stabilization GO:0000000 PMID: 20123964 +involved_in regulation of cellular compo... GO:0000000 - +involved_in regulation of neuron project... GO:0000000 - +involved_in regulation of protein kinase... GO:0000000 PMID: 21873635 +involved_in regulation of protein stabil... GO:0000000 PMID: 10866658 +involved_in rhythmic synaptic transmissi... GO:0000000 - +involved_in social behavior GO:0000000 - +involved_in synapse assembly GO:0000000 - +involved_in synapse maturation GO:0000000 - + +Component GO ID Evidence +------------------------------------------------------------------------------------------------- +located_in PML body GO:0000000 - +located_in Schmidt-Lanterman incisure GO:0000000 - +located_in apical plasma membrane GO:0000000 PMID: 24862762 +is_active_in cell projection GO:0000000 PMID: 21873635 +located_in cell projection GO:0000000 PMID: 10760291,25007873 +located_in cytoplasm GO:0000000 PMID: 9187108,10760291,10940933,21241890,24862762 +located_in cytoplasm GO:0000000 PMID: 9367992 +located_in cytoplasmic side of plasma me... GO:0000000 PMID: 10940933 +is_active_in cytosol GO:0000000 PMID: 21873635 +located_in cytosol GO:0000000 - +located_in cytosol GO:0000000 - +located_in dendritic spine GO:0000000 - +located_in extracellular region GO:0000000 - +located_in myelin sheath adaxonal region GO:0000000 - +located_in neuron projection GO:0000000 - +located_in nucleoplasm GO:0000000 - +located_in nucleoplasm GO:0000000 - +is_active_in nucleus GO:0000000 PMID: 21873635 +located_in nucleus GO:0000000 PMID: 17218261,21241890,24862762 +is_active_in plasma membrane GO:0000000 PMID: 21873635 +located_in plasma membrane GO:0000000 PMID: 10760291 +located_in postsynaptic density GO:0000000 - + +GENERAL PROTEIN INFORMATION +------------------------------------------------------------------------------------------------- +Preferred Names + phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN +Names + MMAC1 phosphatase and tensin homolog deleted on chromosome 10 + PTEN variant PTEN-K267Rfs*9 + PTEN variant PTEN-L247* + PTEN variant PTEN-R234Afs*11 + PTENepsilon + mitochondrial PTENalpha + mitochondrial phosphatase and tensin protein alpha + mutated in multiple advanced cancers 1 + phosphatase and tensin-like protein + phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN + protein tyrosine phosphatase +NP_000305.3 + EC 3.1.3.16 + EC 3.1.3.48 + EC 3.1.3.67 +NP_001291646.4 + EC 3.1.3.16 + EC 3.1.3.48 + EC 3.1.3.67 +NP_001291647.1 + EC 3.1.3.16 + EC 3.1.3.48 + EC 3.1.3.67 + +NCBI REFERENCE SEQUENCES (RefSeq) +------------------------------------------------------------------------------------------------- + +RefSeqs maintained independently of Annotated Genomes + +These reference sequences exist independently of genome builds. +These reference sequences are curated independently of the genome annotation cycle, +so their versions may not match the RefSeq versions in the current genome build. +Identify version mismatches by comparing the version of the RefSeq in this section to +the one reported in Genomic regions, transcripts, and products section above. + + Genomic + NG_007466.2 RefSeqGene + Range 5000..113491 + Download GenBank FASTA Sequence Viewer (Graphics) + + + + mRNA and Protein(s) + + NM_000314.8 → NP_000305.3 REVIEWEDphosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform PTEN + + See proteins identical to NP_000305.3 at http://130.14.22.59/ipg/NP_000305.3/ + + Description: Transcript Variant: This variant (1) encodes mu... + Source sequence(s): AC063965 + Consensus CDS: CCDS31238.1 + UniProtKB/TrEMBL: F6KD01 + UniProtKB/Swiss-Prot: P60484 + UniProtKB/Swiss-Prot: Q6ICT7 + + Related Ensembl: ENSP00000361021.3, ENST00000371953.8 + Conserved Domains (2)summary + cd14509: + Location:24 - 181 + PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog + pfam10409: + Location:188 - 349 + PTEN_C2; C2 domain of PTEN tumor-suppressor protein + + NM_001304717.5 → NP_001291646.4 REVIEWEDphosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform PTEN-L + Description: Transcript Variant: This variant (1) encodes mu... + Source sequence(s): AA836562, AC063965, BC005821, U92436 + Related Ensembl: ENSP00000509861.1, ENST00000693560.1 + + NM_001304718.2 → NP_001291647.1 REVIEWEDphosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 3 + + See proteins identical to NP_001291647.1 at http://130.14.22.59/ipg/NP_001291647.1/ + + Description: Transcript Variant: This variant (2) both conta... + Source sequence(s): AA836562, AC063965, BC005821, JF268690, U92436 + UniProtKB/Swiss-Prot: P60484 + + Conserved Domains (1)summary + pfam10409: + Location:1 - 152 + PTEN_C2; C2 domain of PTEN tumor-suppressor protein + +RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03 +The following sections contain reference sequences that belong to a specific genome build. +This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which +this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both +reference and alternate assemblies. Model RNAs and proteins are also reported here. + +Reference GRCh38.p14 Primary Assembly + + Genomic + NC_000010.11 Reference GRCh38.p14 Primary Assembly + Range 87863624..87971929 + Download GenBank FASTA Sequence Viewer (Graphics) + +Reference GRCh38.p14 PATCHES + + Genomic + NW_013171807.1 Reference GRCh38.p14 PATCHES + Range 79448..187718 + Download GenBank FASTA Sequence Viewer (Graphics) + +Alternate T2T-CHM13v2.0 + + Genomic + NC_060934.1 Alternate T2T-CHM13v2.0 + Range 88747527..88855829 + Download GenBank FASTA Sequence Viewer (Graphics) + + + +RELATED SEQUENCES +------------------------------------------------------------------------------------------------- + +Nucleotide Protein +------------------------------------------------------------------------------------------------- +genomic AB009903.1 BAA24090.1 +genomic AC022016.7(81261..163030) None +genomic AC063965.8(76827..185191) None +genomic AF067844.1 AAD13528.1 +genomic AF406618.1 None +genomic AH005966.2 AAC08699.1 +genomic AH007803.2 AAD38372.1 +genomic CH471066.2 EAW50172.1 + EAW50173 + EAW50174 + EAW50175 +genomic CP068268.2(88747528..88855830) None +genomic DQ073384.1 AAY57327.1 +genomic HM849624.1 ADM26749.1 +genomic HM849628.1 ADM26753.1 +genomic HM849629.1 ADM26754.1 +genomic HM849630.1 ADM26755.1 +genomic HM849631.1 ADM26756.1 +genomic HM849634.1 ADM26759.1 +genomic JA692802.1 CCF23296.1 +genomic JA902567.1 CCV19970.1 +genomic JB074276.1 CCV66764.1 +genomic JB759376.1 CDI44160.1 +genomic JQ037769.1 AEZ67434.1 +genomic JQ037770.1 AEZ67435.1 +genomic JQ037771.1 AEZ67436.1 +genomic JQ037772.1 AEZ67437.1 +genomic JQ037773.1 AEZ67438.1 +genomic JQ037774.1 AEZ67429.1 +genomic JQ037775.1 AEZ67430.1 +genomic JQ037776.1 AEZ67431.1 +genomic JQ037777.1 AEZ67432.1 +genomic JQ037778.1 AEZ67433.1 +genomic KF455271.1 None +genomic KT886842.1 AMQ76357.1 + AMQ76358 + AMQ76359 +genomic MG874045.1 AVE00942.1 +genomic MG911695.1 AVZ47052.1 +genomic MZ615337.1 QYC61795.1 +genomic MZ615338.1 QYC61796.1 +genomic MZ615339.1 QYC61797.1 +genomic OK357121.1 UCR97803.1 +genomic OK357122.1 UCR97804.1 +genomic OK357123.1 UCR97805.1 +genomic OK357124.1 UCR97806.1 +genomic OK357125.1 UCR97807.1 +genomic OK357126.1 UCR97808.1 +genomic OK357127.1 UCR97809.1 +genomic OK357128.1 UCR97810.1 +genomic OK357129.1 UCR97811.1 +genomic OK357130.1 UCR97812.1 +genomic OK357131.1 UCR97813.1 +genomic OK357132.1 UCR97814.1 +genomic OK357133.1 UCR97815.1 +genomic OK357134.1 UCR97816.1 +genomic OK357135.1 UCR97817.1 +genomic OK357136.1 UCR97818.1 +genomic OK357137.1 UCR97819.1 +genomic OK357138.1 UCR97820.1 +genomic OK357139.1 UCR97821.1 +genomic OK357140.1 UCR97822.1 +genomic OK357141.1 UCR97823.1 +mRNA AA017584.1 None +mRNA AA836562.1 None +mRNA AI825848.1 None +mRNA AK021619.1 None +mRNA AK024986.1 None +mRNA AK124525.1 None +mRNA AK130076.1 None +mRNA AK313581.1 BAG36351.1 +mRNA BC005821.2 AAH05821.1 +mRNA BG772190.1 None +mRNA BK008756.1 DAA64601.1 +mRNA CA944942.1 None +mRNA CR450306.1 CAG29302.1 +mRNA JF268690.1 ADZ48535.1 +mRNA KJ534922.1 AHW56562.1 +mRNA KX398936.1 ARB02560.1 +mRNA MK783286.1 QID04980.1 +mRNA MW048523.1 UGU37858.1 +mRNA U92436.1 AAC51182.1 +mRNA U93051.1 AAC51183.1 +mRNA U96180.1 AAB66902.1 + +Protein Accession Links +------------------------------------------------------------------------------------------------- +P60484.1 GenPept(/protein/42560209) UniProtKB/Swiss-Prot:P60484 + +GENE LINKOUT +------------------------------------------------------------------------------------------------- +The following LinkOut(www.ncbi.nlm.nih.gov/projects/linkout/index.html) resources +are supplied by external providers. These providers are responsible for +maintaining the links. + +Other Literature Sources + (Free resource) (free) Dryad Digital Repository + Dryad Digital RepositoryDryad Digital Repository + +Chemical Information + (Free resource) (free) Interologous Interaction Database + Interologous Interaction Database + (Order form) MilliporeSigma + Pten productsPten products + +Medical + (Free resource) (free) MedlinePlus Health Information + PTEN genePTEN gene + +Molecular Biology Databases + (Free resource) (free) Bgee database + PTEN gene expressionPTEN gene expression + (Free resource) (free) BioGPS + BioGPS + (Free resource) (free) BioGRID Open Repository of CRISPR Screens (ORCS) + BioGRID CRISPR Screen Phenotypes (85 hits/1159 screens)BioGRID CRISPR Screen Phenotypes (85 hits/1159 screens) + (Free resource) (free) CREB Target Gene Database + CREB Target Gene Database + (Free resource) (Free registration required) (free) Creative Biogene + phosphatase and tensin homologphosphatase and tensin homolog + (Free resource) (free) Eukaryotic Promoter Database + PTEN_1PTEN_1 + (Free resource) (free) GenAge Database of Aging Related Genes + GenAge Database of Aging Related Genes + (Order form) GenScript latest version of gene cDNA ORF Clone + GenScript latest version of gene cDNA ORF Clone + (Free resource) (free) GeneNetwork + Records for gene expression in HumanRecords for gene expression in Human + (Free resource) (free) Genevisible + PTENPTEN + (Free resource) (free) GlyGen glycoinformatics resource + GlyGen glycoinformatics resource + (Free resource) (free) Guide to Pharmacology + phosphatase and tensin homolog genephosphatase and tensin homolog gene + (Free resource) (Free registration required) (free) Human Gene Mutation Database + Human Gene Mutation Database + (Free resource) (free) Human eFP Browser + Human eFP BrowserHuman eFP BrowserHuman eFP Browser + Ingenuity Pathways Analysis + Ingenuity Pathways Analysis + (Free resource) (free) InnateDB + InnateDBInnateDB + (Free resource) (free) InterMine + InterMine + (Free resource) (free) Kyoto Encyclopedia of Genes and Genomes + Kyoto Encyclopedia of Genes and Genomes + (Free resource) (free) Monarch Initiative + Monarch InitiativeMonarch Initiative + (Free resource) (free) OMA Browser: Orthologous MAtrix + OMA Browser: Orthologous MAtrix + (Free resource) (free) OrthoDB catalog of orthologs + OrthologsOrthologs + (Free resource) (free) Pharmacogenomics Knowledge Base + Annotated Pharmacogenomic Information for PTEN [PharmGKB]Annotated Pharmacogenomic Information for PTEN [PharmGKB] + (Free resource) (free) PhosphoSitePlus + PhosphoSitePlus® - comprehensive post-translational modification resourcePhosphoSitePlus® - comprehensive post-translational modification resource + (Free resource) (free) Protein Ontology Consortium + Protein Ontology Consortium + (Free resource) (free) The Gene Wiki + The Gene Wiki + (Free resource) (free) The Weizmann Institute of Science GeneCards and MalaCards databases + GeneCard for PTENGeneCard for PTEN + (Free resource) (free) Vertebrate Genome Annotation (VEGA) database + Vertebrate Genome Annotation (VEGA) database + (Free resource) (free) iRefWeb - iRefIndex release 9.0 - Consolidated Interactome + iRefWeb - iRefIndex release 9.0 - Consolidated Interactome + +Research Materials + (Order form) Addgene Non-profit plasmid repository + Get Plasmids - AddgeneGet Plasmids - Addgene + ExactAntigen/Labome + reagent reviewreagent reviewreagentsreagents + (Order form) GeneCopoeia Inc. + Order miRNA target clonesOrder miRNA target clonesOrder shRNA clonesOrder shRNA clonesOrder promoter cloneOrder promoter clone + (Order form) GeneTex Inc + Find Recombinant Proteins and PeptidesFind Recombinant Proteins and PeptidesFind Quality AntibodiesFind Quality Antibodies + (Order form) Kazusa DNA Research Institute + Kazusa DNA Research InstituteKazusa DNA Research Institute + LifeSpan BioSciences, Inc. + LSBio PTEN ProteinsLSBio PTEN Proteins + (Order form) NITE Biological Resource Center + Human cDNA clones used in NEDO Project / AK124525Human cDNA clones used in NEDO Project / AK124525Human cDNA clones used in NEDO Project / AK313581Human cDNA clones used in NEDO Project / AK313581Human cDNA clones used in NEDO Project / AK021619Human cDNA clones used in NEDO Project / AK021619 + (Order form) Sino Biological Inc. + Human PTEN Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedHuman PTEN Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedHuman PTEN Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedHuman PTEN Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedHuman PTEN Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHuman PTEN Gene cDNA Clone (full-length ORF Clone), expression ready, untagged + +Tools + (Free resource) (free) GeneMANIA + GeneMANIA \ No newline at end of file