Liquid-Biopsy / Git / [0d2861] /Table S3 Genetic variants detected in fragments, in plasma and in both, in female dogs with breast cancer..xlsx

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[0d2861]: / Table S3 Genetic variants detected in fragments, in plasma and in both, in female dogs with breast cancer..xlsx

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#	Tumor_Sample_Barcode	Hugo_Symbol	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele2	dbSNP_RS	HGVSc	HGVSp	HGVSp_Short	Transcript_ID	Exon_Number	Consequence	Amino_acids	Codons	IMPACT
1	P10c	CCNE1	1	121693328	121693328	+	Missense_Mutation	SNP	G	C	novel	c.51C>G	p.Asp17Glu	p.D17E	XM_022426492.1	2021-09-03 00:00:00	missense_variant	D/E	gaC/gaG	MODERATE
2	P10c	GATA3	2	28079026	28079026	+	Missense_Mutation	SNP	G	A	novel	c.806C>T	p.Ala269Val	p.A269V	XM_844060.3	2021-06-04 00:00:00	missense_variant	A/V	gCc/gTc	MODERATE
3	P10c	GATA3	2	28084971	28084972	+	Missense_Mutation	DNP	TC	CT	novel	c.356_357delinsAG	p.Arg119Lys	p.R119K	XM_844060.3	2021-06-03 00:00:00	missense_variant	R/K	aGA/aAG	MODERATE
4	P10c	FGFR4	4	36248985	36248985	+	Missense_Mutation	SNP	C	T	novel	c.889G>A	p.Asp297Asn	p.D297N	XM_005619171.3	2018-07-01 00:00:00	missense_variant	D/N	Gac/Aac	MODERATE
5	P10c	ATM	5	24203364	24203364	+	Missense_Mutation	SNP	C	A	novel	c.7653G>T	p.Glu2551Asp	p.E2551D	XM_014113193.2	52/63	missense_variant	E/D	gaG/gaT	MODERATE
6	P10c	ATM	5	24271502	24271502	+	Missense_Mutation	SNP	T	C	novel	c.1153A>G	p.Lys385Glu	p.K385E	XM_014113193.2	1963-09-01 00:00:00	missense_variant	K/E	Aaa/Gaa	MODERATE
7	P10c	ALOX12	5	32028659	32028659	+	Missense_Mutation	SNP	T	C	novel	c.557T>C	p.Val186Ala	p.V186A	XM_536613.6	2014-05-01 00:00:00	missense_variant	V/A	gTc/gCc	MODERATE
8	P10c	ALOX12	5	32028669	32028670	+	Missense_Mutation	DNP	CA	TG	novel	c.567_568inv	p.Ile190Val	p.I190V	XM_536613.6	2014-05-01 00:00:00	missense_variant	RI/RV	cgCAtc/cgTGtc	MODERATE
9	P10c	ALOX12	5	32030679	32030680	+	Missense_Mutation	DNP	GT	TC	novel	c.1033_1034delinsTC	p.Val345Ser	p.V345S	XM_536613.6	2014-08-01 00:00:00	missense_variant	V/S	GTc/TCc	MODERATE
10	P10c	ALOX12	5	32030712	32030712	+	Missense_Mutation	SNP	C	G	novel	c.1066C>G	p.Gln356Glu	p.Q356E	XM_536613.6	2014-08-01 00:00:00	missense_variant	Q/E	Cag/Gag	MODERATE
11	P10c	ALOX12	5	32030715	32030715	+	Missense_Mutation	SNP	C	A	novel	c.1069C>A	p.Leu357Ile	p.L357I	XM_536613.6	2014-08-01 00:00:00	missense_variant	L/I	Ctc/Atc	MODERATE
12	P10c	ALOX12	5	32033839	32033840	+	Frame_Shift_Ins	INS	-	GG	novel	c.1295_1296insGG	p.Met433AlafsTer5	p.M433Afs*5	XM_536613.6	2014-10-01 00:00:00	frameshift_variant	A/AX	gcc/gcGGc	HIGH
13	P10c	ALOX12	5	32033842	32033843	+	Frame_Shift_Del	DEL	TG	-	novel	c.1298_1299del	p.Met433SerfsTer12	p.M433Sfs*12	XM_536613.6	2014-10-01 00:00:00	frameshift_variant	M/X	aTG/a	HIGH
14	P10c	ALOX12	5	32033859	32033859	+	Missense_Mutation	SNP	C	T	novel	c.1315C>T	p.Arg439Cys	p.R439C	XM_536613.6	2014-10-01 00:00:00	missense_variant	R/C	Cgt/Tgt	MODERATE
15	P10c	PMS2	6	11428992	11428992	+	Missense_Mutation	SNP	G	A	novel	c.958C>T	p.Arg320Trp	p.R320W	XM_014114296.2	2015-08-01 00:00:00	missense_variant	R/W	Cgg/Tgg	MODERATE
16	P10c	PMS2	6	11436377	11436377	+	Missense_Mutation	SNP	C	G	novel	c.217G>C	p.Val73Leu	p.V73L	XM_014114296.2	2015-02-01 00:00:00	missense_variant	V/L	Gtg/Ctg	MODERATE
17	P10c	PMS2	6	11436385	11436385	+	Missense_Mutation	SNP	T	C	novel	c.209A>G	p.Glu70Gly	p.E70G	XM_014114296.2	2015-02-01 00:00:00	missense_variant	E/G	gAa/gGa	MODERATE
18	P10c	PMS2	6	11436392	11436392	+	Missense_Mutation	SNP	A	T	novel	c.202T>A	p.Leu68Met	p.L68M	XM_014114296.2	2015-02-01 00:00:00	missense_variant	L/M	Ttg/Atg	MODERATE
19	P10c	PMS2	6	11436395	11436395	+	Missense_Mutation	SNP	C	T	novel	c.199G>A	p.Glu67Lys	p.E67K	XM_014114296.2	2015-02-01 00:00:00	missense_variant	E/K	Gag/Aag	MODERATE
20	P10c	PMS2	6	11436426	11436427	+	Missense_Mutation	DNP	TT	CG	novel	c.167_168delinsCG	p.Gln56Pro	p.Q56P	XM_014114296.2	2015-02-01 00:00:00	missense_variant	Q/P	cAA/cCG	MODERATE
21	P10c	PMS2	6	11436484	11436484	+	Missense_Mutation	SNP	A	G	novel	c.110T>C	p.Leu37Pro	p.L37P	XM_014114296.2	2015-02-01 00:00:00	missense_variant	L/P	cTt/cCt	MODERATE
22	Tumor_Sample_Barcode	Hugo_Symbol	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele2	dbSNP_RS	HGVSc	HGVSp	HGVSp_Short	Transcript_ID	Exon_Number	Consequence	Amino_acids	Codons	IMPACT
23	P10c	PALB2	6	22215798	22215798	+	Missense_Mutation	SNP	G	T	novel	c.505G>T	p.Asp169Tyr	p.D169Y	XM_845578.5	2013-04-01 00:00:00	missense_variant	D/Y	Gat/Tat	MODERATE
24	P10c	TGFBR3	6	57188895	57188895	+	Missense_Mutation	SNP	G	C	novel	c.1978G>C	p.Asp660His	p.D660H	XM_005621935.3	13/17	missense_variant	D/H	Gat/Cat	MODERATE
25	P10c	TGFBR3	6	57188903	57188904	+	Missense_Mutation	DNP	TA	CC	novel	c.1986_1987delinsCC	p.Ile663Leu	p.I663L	XM_005621935.3	13/17	missense_variant	TI/TL	acTAtc/acCCtc	MODERATE
26	P10c	TGFBR3	6	57188910	57188910	+	Nonsense_Mutation	SNP	G	T	novel	c.1993G>T	p.Glu665Ter	p.E665*	XM_005621935.3	13/17	stop_gained	E/*	Gaa/Taa	HIGH
27	P10c	TGFBR3	6	57188920	57188920	+	Missense_Mutation	SNP	G	T	novel	c.2003G>T	p.Cys668Phe	p.C668F	XM_005621935.3	13/17	missense_variant	C/F	tGt/tTt	MODERATE
28	P10c	TGFBR3	6	57188928	57188928	+	Missense_Mutation	SNP	G	A	novel	c.2011G>A	p.Asp671Asn	p.D671N	XM_005621935.3	13/17	missense_variant	D/N	Gat/Aat	MODERATE
29	P10c	EXO1	7	33239140	33239140	+	Missense_Mutation	SNP	A	G	novel	c.161A>G	p.Lys54Arg	p.K54R	XM_003639186.4	2015-03-01 00:00:00	missense_variant,splice_region_variant	K/R	aAg/aGg	MODERATE
30	P10c	AKT1	8	72320612	72320612	+	Missense_Mutation	SNP	G	T	novel	c.1027C>A	p.Leu343Met	p.L343M	XM_022422422.1	2014-11-01 00:00:00	missense_variant	L/M	Ctg/Atg	MODERATE
31	P10c	KRT17	9	21156757	21156757	+	Missense_Mutation	SNP	A	G	novel	c.365A>G	p.Lys122Arg	p.K122R	XM_548100.5	2021-09-02 00:00:00	missense_variant	K/R	aAg/aGg	MODERATE
32	P10c	KRT17	9	21156791	21156791	+	Missense_Mutation	SNP	C	G	novel	c.399C>G	p.His133Gln	p.H133Q	XM_548100.5	2021-09-02 00:00:00	missense_variant	H/Q	caC/caG	MODERATE
33	P10c	KRT17	9	21156798	21156799	+	Missense_Mutation	DNP	CA	AG	novel	c.406_407delinsAG	p.Gln136Arg	p.Q136R	XM_548100.5	2021-09-02 00:00:00	missense_variant	Q/R	CAg/AGg	MODERATE
34	P10c	KRT17	9	21156812	21156812	+	Missense_Mutation	SNP	C	G	novel	c.420C>G	p.Asp140Glu	p.D140E	XM_548100.5	2021-09-02 00:00:00	missense_variant	D/E	gaC/gaG	MODERATE
35	P10c	KRT17	9	21156816	21156816	+	Missense_Mutation	SNP	A	C	novel	c.424A>C	p.Lys142Gln	p.K142Q	XM_548100.5	2021-09-02 00:00:00	missense_variant	K/Q	Aag/Cag	MODERATE
36	P10c	CDC6	9	22306187	22306187	+	Missense_Mutation	SNP	T	G	novel	c.1345A>C	p.Lys449Gln	p.K449Q	XM_005624534.3	2021-12-10 00:00:00	missense_variant	K/Q	Aaa/Caa	MODERATE
37	P10c	CDC6	9	22314384	22314384	+	Missense_Mutation	SNP	T	C	novel	c.535A>G	p.Asn179Asp	p.N179D	XM_005624534.3	2021-12-04 00:00:00	missense_variant	N/D	Aat/Gat	MODERATE
38	P10c	CDC6	9	22314392	22314392	+	Missense_Mutation	SNP	T	C	novel	c.527A>G	p.Lys176Arg	p.K176R	XM_005624534.3	2021-12-04 00:00:00	missense_variant	K/R	aAg/aGg	MODERATE
39	P10c	ERBB2	9	22761207	22761207	+	Missense_Mutation	SNP	C	T	novel	c.3631G>A	p.Ala1211Thr	p.A1211T	XM_022422534.1	27/27	missense_variant	A/T	Gca/Aca	MODERATE
40	P10c	ERBB2	9	22761609	22761609	+	Nonsense_Mutation	SNP	G	A	novel	c.3352C>T	p.Gln1118Ter	p.Q1118*	XM_022422534.1	26/27	stop_gained	Q/*	Cag/Tag	HIGH
41	P10c	ERBB2	9	22763074	22763074	+	Missense_Mutation	SNP	C	T	novel	c.2758G>A	p.Ala920Thr	p.A920T	XM_022422534.1	23/27	missense_variant	A/T	Gcc/Acc	MODERATE
42	P10c	ERBB2	9	22770548	22770549	+	Missense_Mutation	DNP	AT	TC	novel	c.1550_1551delinsGA	p.His517Arg	p.H517R	XM_022422534.1	13/27	missense_variant	H/R	cAT/cGA	MODERATE
43	P10c	ERBB2	9	22770561	22770561	+	Missense_Mutation	SNP	G	T	novel	c.1538C>A	p.Pro513Gln	p.P513Q	XM_022422534.1	13/27	missense_variant	P/Q	cCg/cAg	MODERATE
44	P10c	ERBB2	9	22770565	22770565	+	Missense_Mutation	SNP	A	G	novel	c.1534T>C	p.Tyr512His	p.Y512H	XM_022422534.1	13/27	missense_variant	Y/H	Tac/Cac	MODERATE
45	P10c	ERBB2	9	22775543	22775543	+	Missense_Mutation	SNP	G	A	novel	c.847C>T	p.Pro283Ser	p.P283S	XM_022422534.1	2027-07-01 00:00:00	missense_variant	P/S	Ccc/Tcc	MODERATE
46	P10c	RAD51C	9	33293917	33293917	+	Missense_Mutation	SNP	C	G	novel	c.516C>G	p.His172Gln	p.H172Q	XM_022423222.1	2021-10-03 00:00:00	missense_variant	H/Q	caC/caG	MODERATE
47	P10c	RAD51C	9	33293928	33293928	+	Missense_Mutation	SNP	G	A	novel	c.527G>A	p.Gly176Glu	p.G176E	XM_022423222.1	2021-10-03 00:00:00	missense_variant	G/E	gGa/gAa	MODERATE
48	P10c	RAD51C	9	33293931	33293931	+	Missense_Mutation	SNP	G	A	novel	c.530G>A	p.Arg177Lys	p.R177K	XM_022423222.1	2021-10-03 00:00:00	missense_variant	R/K	aGa/aAa	MODERATE
49	P10c	RAD51C	9	33293937	33293937	+	Missense_Mutation	SNP	T	A	novel	c.536T>A	p.Met179Lys	p.M179K	XM_022423222.1	2021-10-03 00:00:00	missense_variant	M/K	aTg/aAg	MODERATE
50	P10c	NF1	9	41482817	41482817	+	Missense_Mutation	SNP	C	G	novel	c.8212G>C	p.Gly2738Arg	p.G2738R	XM_022423324.1	57/58	missense_variant,splice_region_variant	G/R	Gga/Cga	MODERATE
51	P10c	NF1	9	41587157	41587157	+	Missense_Mutation	SNP	G	A	novel	c.4097C>T	p.Pro1366Leu	p.P1366L	XM_022423324.1	32/58	missense_variant	P/L	cCg/cTg	MODERATE
52	P10c	NF1	9	41587169	41587169	+	Missense_Mutation	SNP	G	T	novel	c.4085C>A	p.Ala1362Asp	p.A1362D	XM_022423324.1	32/58	missense_variant	A/D	gCc/gAc	MODERATE
53	P10c	NF1	9	41587177	41587177	+	Missense_Mutation	SNP	G	C	novel	c.4077C>G	p.Ile1359Met	p.I1359M	XM_022423324.1	32/58	missense_variant	I/M	atC/atG	MODERATE
54	P10c	NF1	9	41587204	41587205	+	Missense_Mutation	DNP	CA	TG	novel	c.4049_4050inv	p.Val1350Ala	p.V1350A	XM_022423324.1	32/58	missense_variant	V/A	gTG/gCA	MODERATE
55	P10c	NF1	9	41587212	41587212	+	Missense_Mutation	SNP	C	T	novel	c.4042G>A	p.Gly1348Ser	p.G1348S	XM_022423324.1	32/58	missense_variant	G/S	Ggt/Agt	MODERATE
56	P10c	NF1	9	41587244	41587244	+	Missense_Mutation	SNP	A	C	novel	c.4010T>G	p.Val1337Gly	p.V1337G	XM_022423324.1	32/58	missense_variant,splice_region_variant	V/G	gTg/gGg	MODERATE
57	F1	BCL2	1	13900319	13900319	+	Missense_Mutation	SNP	G	C	novel	c.568G>C	p.Ala190Pro	p.A190P	NM_001002949.1	2021-04-04 00:00:00	missense_variant	A/P	Gcc/Ccc	MODERATE
58	F1	BCL2	1	13900326	13900326	+	Missense_Mutation	SNP	T	G	novel	c.575T>G	p.Val192Gly	p.V192G	NM_001002949.1	2021-04-04 00:00:00	missense_variant	V/G	gTg/gGg	MODERATE
59	F1	GATA3	2	28084971	28084972	+	Missense_Mutation	DNP	TC	CT	novel	c.356_357delinsAG	p.Arg119Lys	p.R119K	XM_844060.3	2021-06-03 00:00:00	missense_variant	R/K	aGA/aAG	MODERATE
60	F1	MTOR	2	84833425	84833425	+	Splice_Site	SNP	G	C	novel	c.841-1G>C	nan	p.X281_splice	XM_005618003.3	nan	splice_acceptor_variant	nan	nan	HIGH
61	F1	MTOR	2	84833430	84833430	+	Missense_Mutation	SNP	T	C	novel	c.845T>C	p.Leu282Pro	p.L282P	XM_005618003.3	1958-07-01 00:00:00	missense_variant	L/P	cTg/cCg	MODERATE
62	F1	ATM	5	24265195	24265195	+	Missense_Mutation	SNP	C	T	novel	c.2137G>A	p.Glu713Lys	p.E713K	XM_014113193.2	14/63	missense_variant	E/K	Gag/Aag	MODERATE
63	F1	FOXC2	5	66295345	66295345	+	Missense_Mutation	SNP	G	T	novel	c.349C>A	p.Gln117Lys	p.Q117K	XM_014113959.2	2021-02-01 00:00:00	missense_variant	Q/K	Cag/Aag	MODERATE
64	F1	FOXC2	5	66295348	66295348	+	Missense_Mutation	SNP	A	C	novel	c.346T>G	p.Trp116Gly	p.W116G	XM_014113959.2	2021-02-01 00:00:00	missense_variant	W/G	Tgg/Ggg	MODERATE
65	F1	FOXC2	5	66295383	66295383	+	Missense_Mutation	SNP	T	G	novel	c.311A>C	p.Asp104Ala	p.D104A	XM_014113959.2	2021-02-01 00:00:00	missense_variant	D/A	gAc/gCc	MODERATE
66	F1	TGFBR3	6	57181657	57181657	+	Missense_Mutation	SNP	T	G	novel	c.1577T>G	p.Val526Gly	p.V526G	XM_005621935.3	2017-10-01 00:00:00	missense_variant	V/G	gTt/gGt	MODERATE
67	F1	FOXA1	8	16079618	16079620	+	In_Frame_Del	DEL	CCG	-	novel	c.879_881del	p.Gly294del	p.G294del	XM_847261.4	2021-05-02 00:00:00	inframe_deletion	GG/G	ggCGGa/gga	MODERATE
68	F1	AKT1	8	72321248	72321248	+	Missense_Mutation	SNP	A	G	novel	c.650T>C	p.Phe217Ser	p.F217S	XM_022422422.1	2014-08-01 00:00:00	missense_variant	F/S	tTc/tCc	MODERATE
69	F1	BRIP1	9	34854418	34854418	+	Missense_Mutation	SNP	T	A	novel	c.718T>A	p.Ser240Thr	p.S240T	XM_847556.5	2020-07-01 00:00:00	missense_variant	S/T	Tcc/Acc	MODERATE
70	F1	BRIP1	9	34854442	34854442	+	Missense_Mutation	SNP	G	T	novel	c.742G>T	p.Gly248Trp	p.G248W	XM_847556.5	2020-07-01 00:00:00	missense_variant	G/W	Ggg/Tgg	MODERATE
71	F1	NF1	9	41484290	41484290	+	Splice_Site	SNP	A	C	novel	c.7995+2T>G	nan	p.X2665_splice	XM_022423324.1	nan	splice_donor_variant	nan	nan	HIGH
72	F1	CDK2	10	302984	302984	+	Missense_Mutation	SNP	A	G	novel	c.394A>G	p.Asn132Asp	p.N132D	XM_005625479.3	2021-08-04 00:00:00	missense_variant	N/D	Aat/Gat	MODERATE
73	F1	CDK2	10	302995	302995	+	Missense_Mutation	SNP	C	G	novel	c.405C>G	p.Ile135Met	p.I135M	XM_005625479.3	2021-08-04 00:00:00	missense_variant	I/M	atC/atG	MODERATE
74	F1	CDK2	10	303006	303006	+	Missense_Mutation	SNP	G	T	novel	c.416G>T	p.Gly139Val	p.G139V	XM_005625479.3	2021-08-04 00:00:00	missense_variant	G/V	gGg/gTg	MODERATE
75	F1	CDK2	10	303012	303013	+	Missense_Mutation	DNP	TC	GG	novel	c.422_423delinsGG	p.Ile141Arg	p.I141R	XM_005625479.3	2021-08-04 00:00:00	missense_variant	I/R	aTC/aGG	MODERATE
76	F1	CDK2	10	303026	303026	+	Missense_Mutation	SNP	T	C	novel	c.436T>C	p.Phe146Leu	p.F146L	XM_005625479.3	2021-08-04 00:00:00	missense_variant	F/L	Ttt/Ctt	MODERATE
77	F1	MELK	11	53050586	53050586	+	Nonsense_Mutation	SNP	C	A	novel	c.1199C>A	p.Ser400Ter	p.S400*	XM_014117862.2	14/18	stop_gained	S/*	tCa/tAa	HIGH
78	F1	SFRP1	16	24262826	24262827	+	Frame_Shift_Ins	INS	-	A	rs851244653	c.374_375insA	p.Phe125LeufsTer9	p.F125Lfs*9	XM_003639564.2	2021-04-02 00:00:00	frameshift_variant,splice_region_variant	F/LX	ttc/ttAc	HIGH
79	F1	RRM2	17	7106660	7106660	+	Missense_Mutation	SNP	A	G	novel	c.109A>G	p.Asn37Asp	p.N37D	XM_540076.6	2021-10-01 00:00:00	missense_variant	N/D	Aac/Gac	MODERATE
80	F1	RRM2	17	7106665	7106737	+	Splice_Site	DEL	GGTGAGCGCGCGCGCGGGCCCGGGGGCGGGGACCTGAGGGCCGGGGCTGCCCCTCACCGCGCGTCTCCCCGCA	-	novel	c.114+1_115-1del	nan	p.X38_splice	XM_540076.6	2021-10-01 00:00:00	splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant	nan	nan	HIGH
81	F1	RRM2	17	7110434	7110435	+	Frame_Shift_Ins	INS	-	GGAGAACG	novel	c.679+1_679+2insAGAACGGG	nan	nan	XM_540076.6	2021-10-06 00:00:00	frameshift_variant,splice_region_variant	-/GEX	-/GGAGAACG	HIGH
82	F1	BRCA2	25	7735412	7735413	+	In_Frame_Ins	INS	-	TTT	rs853007536	c.9995_9996insAAA	p.Met3332delinsIleLys	p.M3332delinsIK	XM_014107324.2	27/27	protein_altering_variant	M/IK	atg/atAAAg	MODERATE
83	F1	BRCA2	25	7768691	7768693	+	In_Frame_Del	DEL	AAC	-	rs397511123	c.6918_6920del	p.Leu2307del	p.L2307del	XM_014107324.2	2027-12-01 00:00:00	inframe_deletion	LL/L	ttGTTa/tta	MODERATE
84	F1	CEP55	28	7771788	7771789	+	Frame_Shift_Ins	INS	-	T	rs852818748	c.593dup	p.Leu198PhefsTer6	p.L198Ffs*6	XM_022411809.1	2021-10-06 00:00:00	frameshift_variant,splice_region_variant	A/AX	gct/gcTt	HIGH
85	F1	CEP55	28	7777487	7777488	+	Missense_Mutation	DNP	GT	TC	novel	c.1332_1333delinsTC	p.Gln444_Tyr445delinsHisHis	p.Q444_Y445delinsHH	XM_022411809.1	2021-10-10 00:00:00	missense_variant	QY/HH	caGTac/caTCac	MODERATE
86	F1	USH2A	38	11066225	11066225	+	Missense_Mutation	SNP	A	C	novel	c.15504T>G	p.Ser5168Arg	p.S5168R	XM_545710.4	70/71	missense_variant	S/R	agT/agG	MODERATE
87	F1	USH2A	38	11066228	11066228	+	Missense_Mutation	SNP	A	T	novel	c.15501T>A	p.Asp5167Glu	p.D5167E	XM_545710.4	70/71	missense_variant	D/E	gaT/gaA	MODERATE
88	Both	GATA3	2	28084971	28084972	+	Missense_Mutation	DNP	TC	CT	novel	c.356_357delinsAG	p.Arg119Lys	p.R119K	XM_844060.3	2021-06-03 00:00:00	missense_variant	R/K	aGA/aAG	MODERATE