Parkinson-HMR

Creators

Giuliano Claudio
Siani Francesca
Mus Liudmilla
Ghezzi Cristina
Cerri Silvia
Pacchetti Barbara
Bigogno Chiara
Blandini Fabio

Description

The database includes the raw data of the article “Neuroprotective effects of lignan 7-hydroxymatairesinol (HMR/lignan) in a rodent model of Parkinson’s disease” (doi.org/10.1016/j.nut.2019.04.006). The aim of this study was to evaluate the effects of chronic treatment with lignan 7-hydroxymatairesinol (HMR/lignan) on Parkinson’s disease-associated neurodegenerative and neuroinflammatory processes, and motor deficits in the 6-hydroxydopamine (6-OHDA) model. The database contains the data obtained by the following evaluations: a) immunohistochemical analysis of the extent of nigrostriatal lesion, b) motor performance assessment by cylinder test (at baseline and after 28days), apomorphine-induced rotation test, c) immunohistochemical analysis of neuroinflammatory response - involving microglia and astrocytes - in the substantia nigra pars compacta, investigating both cell activation and polarization.

chronic treatment with HMR/lignan was able to slow down the progression of degeneration of striatal dopaminergic terminals in a rat model of PD, with a consequent improvement in motor performance. Nevertheless, the anti-inflammatory effect of HMR/lignan observed in SNc was not sufficient to protect dopaminergic cells bodies. These results suggest intriguing properties of HMR/lignan at neuroprotective and symptomatic levels in the context of PD.